Effects of epinephrine on plasma cholesterol levels in rats.

Kunihara, Minea; Oshima, Takao

doi:10.1016/s0022-2275(20)37969-4

Cited by 31 publications

(3 citation statements)

References 31 publications

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“…Catecholamines were included to index sympathetic nervous system activity. We also measured cortisol concentrations during acute stress because of the predictability of stress-induced cortisol responsivity (Forsman & Lundberg, 1982), and because of the important role of cortisol in lipid metabolism (Kunihara & Oshima, 1983). After blood was drawn, it was immediately placed on crushed ice, and centrifuged within 5 min of sampling for 10 min at 3,500 rpm.…”

Section: Methodsmentioning

confidence: 99%

Lipid reactivity to stress: II. Biological and behavioral influences.

Stoney¹,

Bausserman²,

Niaura³

et al. 1999

Health Psychology

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This study examined behavioral and physiological influences on lipid concentrations during acute and chronic stressors. One hundred men (n = 92) and women (n = 8) were tested during a chronic stressor and during 2 acute stressors. During chronic stress, diet, physical activity, exercise, and sleep were examined. During the acute stressors, catecholamines, cortisol, plasma volume, and cardiovascular responses were examined. None of the behavioral influences could explain the lipid response to chronic stress. Responses of the atherogenic lipids to acute stressors were not solely reflecting hemoconcentration of the plasma but were moderately correlated with cardiovascular, epinephrine, and cortisol reactivity. Diastolic blood pressure reactors to the acute stressors had larger lipid responses to the chronic stressor than did nonreactors. Elevations in blood lipids during stress are not artifacts and may be clinically significant.

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Section: Methodsmentioning

confidence: 99%

Lipid reactivity to stress: II. Biological and behavioral influences.

Stoney¹,

Bausserman²,

Niaura³

et al. 1999

Health Psychology

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“…Sphingosine can also attenuate the affinity of transporter Niemann Pick C1 like 1 (NPC1L1) toward cholesterol ( 86 ). Additionally, tyrosine can be converted to adrenaline, which further promotes the process of lipid hydrolysis in vivo ( 87 ), and α-tocotrienol and γ-tocotrienol downregulate the expression of HMG CoA reductase to inhibit the synthesis of endogenous cholesterol and linoleic acid promotes β-oxidation, thus reducing the synthesis of endogenous triglycerides (TGs). Butyrate accelerates the hydrolysis of fatty acids, leading to a reduction in the concentration of TGs in the blood, and can also block the transportation of Very Low-Density Lipoprotein Cholesterol (VLDL-C) from the liver to the blood ( 84 ).…”

Section: Prevention Of Chronic Diseases By Drinking Koumissmentioning

confidence: 99%

Nutritional ingredients and prevention of chronic diseases by fermented koumiss: a comprehensive review

Xue,

Yuan,

et al. 2023

Front. Nutr.

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Koumiss, a traditional fermented dairy product made from fresh mare milk, is a sour beverage that contains an abundance of microbial communities, including lactic acid bacteria, yeast and others. Firstly, probiotics such as Lacticaseibacillus in koumiss can induce the secretion of immunoglobulin G in serum and interleukin-2 in the spleen while beneficial Saccharomyces can secrete antibacterial compounds such as citric acid and ascorbic acid for specific immunopotentiation. Additionally, more isoflavone in koumiss can regulate estrogen levels by binding to its receptors to prevent breast cancer directly. Bile salts can be converted into bile acids such as taurine or glycine by lactic acid bacteria to lower cholesterol levels in vivo. Butyric acid secretion would be increased to improve chronic gastrotis by regulating intestinal flora with lactic acid bacteria. Finally, SCFA and lCFA produced by Lacticaseibacillus inhibit the reproduction of pathogenic microorganisms for diarrhea prevention. Therefore, exploring the mechanisms underlying multiple physiological functions through utilizing microbial resources in koumiss represents promising avenues for ameliorating chronic diseases.

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“…An infusion of epinephrine elevates plasma cholesterol in rats (Kunihara & Oshima, 1983) and cynomolgus monkeys (Dimsdale, Herd, & Hartley, 19781, and an infusion of norepinephrine elevates both plasma cholesterol and triglyceride levels in rabbits (ODonnell et al, 1988). A disparity of plasma epinephrine and norepinephrine levels during different stress responses in humans suggested that psychological stress primarily stimulates an adrenomedullary response, whereas exercise stimulates a larger noradrenergic response (Dimsdale & Moss, 1980).…”

Section: The Sympathetic Nervous System As Mediator Of Effects Of Emo...mentioning

confidence: 99%

Neurogenic and behavioral influences on plasma lipids.

Rosenman¹

1997

Lipids, Health, and Behavior.

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A population study (Keys, Mickelsen, Miller, Hayes, & Todd, 1951) led to an early belief that plasma cholesterol levels were stable in adults, aside from small age-related increases. However, the dominant role of genetic factors in regulation of individual cholesterol levels (Christian et al., 1987) decreases with age (Heller, de Faire, Pedersen, Dahlen, & McClearn, 1993). It therefore is not surprising that under standardized conditions, within-person weekly levels of plasma cholesterol vary by 20% or more in adults or that these levels have a significant 10%-20% day-to-day variability that cannot be ascribed to dietary changes (Bookstein, Gidding, Donovan, & Smith, 1990;Mogadam, Ahmed, Mensh, & Godwin, 1991).There is considerable evidence to document a major role of the sympathetic nervous system in this variability. It also may play an important role in the rise of plasma total cholesterol that can transiently occur during emotional stress and in higher levels that are associated with certain personality and behavioral characteristics (Dimsdale

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Effects of epinephrine on plasma cholesterol levels in rats.

Cited by 31 publications

References 31 publications

Lipid reactivity to stress: II. Biological and behavioral influences.

Lipid reactivity to stress: II. Biological and behavioral influences.

Nutritional ingredients and prevention of chronic diseases by fermented koumiss: a comprehensive review

Neurogenic and behavioral influences on plasma lipids.

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