Effects of Equipotent Ephedrine, Metaraminol, Mephentermine, and Methoxamine on Uterine Blood Flow in the Pregnant Ewe

Ralston, David H.; Shnider, Sol M.; deLorimier, Alfred A.

doi:10.1097/00000542-197404000-00009

Cited by 247 publications

(88 citation statements)

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“…The results of this study are important because animal studies have shown that phenylephrine and other alpha adrenergic agonists have a greater propensity to reduce uteroplacental perfusion compared with ephedrine [1]. Although this does not appear to be clinically relevant in healthy, low-risk elective cases [3][4][5], it has not been known whether the same would apply in the presence of [7,8] compared phenylephrine and ephedrine for correcting epidural-induced hypotension after a period of maternal hypoxaemia in a chronically-instrumented sheep model.…”

Section: Discussionmentioning

confidence: 96%

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Randomised double‐blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non‐elective Caesarean section*

Kee

Khaw

Lau³

et al. 2008

Anaesthesia

109

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SummaryIn a randomised, double-blinded study, we compared boluses of phenylephrine 100 lg with ephedrine 10 mg for treating hypotension (systolic blood pressure < 100 mmHg) in 204 patients having non-elective Caesarean section under spinal anaesthesia. Umbilical arterial (UA) and venous (UV) pH and base excess were similar between groups. In the ephedrine group, UA lactate concentration was higher (median 2.6 [interquartile range 2.

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Section: Discussionmentioning

confidence: 96%

“…Early animal studies suggested that alpha-adrenergic agonists given during pregnancy have the potential to decrease uteroplacental perfusion [1]. However, more recent clinical studies of the use of alpha agonists during spinal anaesthesia for Caesarean section have not shown evidence of detrimental effects [2][3][4][5].…”

mentioning

confidence: 99%

Randomised double‐blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non‐elective Caesarean section*

Kee

Khaw

Lau³

et al. 2008

Anaesthesia

109

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“…Ephedrine is widely used because of its predominantly b and mild a sympathominetic action. Ephedrine increases cardiac out put & therefore flow to the maximally dilated utero placental vessels 15 . Incremental I/V bolus dose of ephedrine counteract hypotension.…”

Section: Discussionmentioning

confidence: 99%

Effect of magnesium sulphate on quality of subarachnoid block in terms of onset and duration of motor and sensory block, APGAR score of the neonate and haemodynamic status of the patient

Hossain

Mondal

Roy³

et al. 2014

j Bangladesh Soc Anaesthesiologists

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“…In these patients, the tone and gastric motility also decreases as a result of increased levels of progesterone and displacement of the stomach by enlarged uterus [17]. Gastric emptying time is not prolonged during pregnancy, but overall gastrointestinal time is [22]. During pregnancy the response of the autonomic nervous system against hemodynamic changes is biphasic.…”

Section: Physiological Changes Of Pregnancymentioning

confidence: 99%

Anesthesia for Non-Obstetrical Surgery during Pregnancy

Mandim¹

2014

General Med

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The number of surgical procedures in gravid women unrelated to pregnancy itself has been increased over years. In such cases, one must keep in mind the responsibility for two patients, the optimization and maintenance of maternal homeostasis, avoiding alterations on uteroplacental perfusion that can bring harm to the fetus. This review focus on safety to performing these procedures during pregnancy, considering the advances in the prevention and treatment of obstetric and fetal morbidity related to anesthesia. Background and Objectives:Despite research advances, there is still much controversy in the anesthetic management of obstetric patients. Several studies have demonstrated the safety of anesthesia in this group of patients. In this review an analysis of anesthetics used in clinical practice is proposed as well as the technique to be chosen and its effects on the mother and fetus in non-obstetric surgery during pregnancy.

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Effects of Equipotent Ephedrine, Metaraminol, Mephentermine, and Methoxamine on Uterine Blood Flow in the Pregnant Ewe

Cited by 247 publications

References 0 publications

Randomised double‐blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non‐elective Caesarean section*

Randomised double‐blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non‐elective Caesarean section*

Effect of magnesium sulphate on quality of subarachnoid block in terms of onset and duration of motor and sensory block, APGAR score of the neonate and haemodynamic status of the patient

Anesthesia for Non-Obstetrical Surgery during Pregnancy

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