Effects of eradication of Helicobacter pylori on oral malodor and the oral environment: a single-center observational study

Abstract

Objective: Although a relationship between Helicobacter pylori and oral malodor has been suggested, it remains to be confirmed. One reason for this is that many studies assess oral malodor subjectively. Another reason for the uncertainty is that the reduction in oral malodor may be due to the effect of antibiotics on the oral microbiota. In this study, changes in oral malodor and the eradication treatment of H. pylori were investigated by organoleptic test and gas chromatography. In addition, the salivary bacterial composition and clinical parameters were analyzed.Results: The organoleptic test score, hydrogen sulfide and dimethyl sulfide concentrations, and all clinical parameters except for tongue-coating score were significantly decreased at 1 week compared with baseline. Although antibiotic treatment also altered the overall composition of the salivary bacterial population, it had recovered at 7 weeks. On the date that H. pylori was determined to have been eradicated from all of the subjects (7 weeks after treatment), only the organoleptic test score was significantly lower compared with baseline. The hydrogen sulfide and dimethyl sulfide concentrations were non-significantly lower than those at baseline.

Analysis of oral microbiota alterations induced by Helicobacter pylori infection and vonoprazan‐amoxicillin dual therapy for Helicobacter pylori eradication

“…29 The overall composition of the oral microbiota was altered immediately after triple therapy but was recovered 7 weeks after H. pylori eradication. 30 VA dual therapy contains only one antibiotic and VPZ, which was considered to induce minimal changes in the host microbiota. Compared with the baseline, the alpha diversities of the gut microbiota were not altered at 1 and 8 weeks after VA dual therapy.…”

“…Compared with BQT, triple therapy showed less influence on the gut microbiota during the long‐term follow‐up primarily because of one fewer drug used in the regimens 29 . The overall composition of the oral microbiota was altered immediately after triple therapy but was recovered 7 weeks after H. pylori eradication 30 . VA dual therapy contains only one antibiotic and VPZ, which was considered to induce minimal changes in the host microbiota.…”

Halitosis as a key diagnostic factor to systemic diseases in the primary care

“…28 These findings were also indicated by previous investigations. [29][30][31][32][33] Accordingly, halitosis is significantly associated with H. pylori infection, and the latter should be adequately diagnosed and managed to enhance the outcomes.…”