Effects of Erythropoietin on Lung Injury Induced by Cardiopulmonary Bypass After Cardiac Surgery

Abstract

Background:Lung injury after cardiopulmonary bypass (CPB) is a serious postoperative complication and can affect the postoperative recovery. The purpose of this study was to explore whether erythropoietin (EPO) has an effect on lung injury caused by CPB. Material/Methods:Sixty patients who received the CPB were randomly divided into a saline group and the EPO group. All the patients received saline or EPO preoperatively, respectively. The ventilation function, including dynamic compliance, peak airway pressure, and plateau pressure, were recorded. The level of tumor necrosis factor (TNF)-a, interleukin (IL)-1b, and IL-10 in serum and arterial blood gas were analyzed. The mechanical ventilation time in the intensive care unit (ICU), the length of time spent in the ICU, the time from operation to discharge, and the total time of hospitalization were recorded. Adverse events in the ICU were monitored and recorded. Results:EPO significantly decreased the level of TNF-a and IL-1b, but increased the level of IL-10 after CPB. EPO significantly improved pulmonary ventilated function and gas exchange function after CPB. EPO significantly shortened the mechanical ventilation time and stay in the ICU. Conclusions:Preoperative EPO injection reduced lung injury and promoted lung function in patients who underwent CPB.The protection effect of EPO may be associated with inhibition of inflammatory response.

The role of annexin A1 peptide in regulating PI3K/Akt signaling pathway to reduce lung injury after cardiopulmonary bypass in rats

“…CPB lung injury is one of the main complications after cardiovascular surgery, and it is also an important cause of postoperative patient death [18] . Studies have shown that tumor necrosis factor and interleukin produced after CPB can directly damage endothelial cells, increase capillary permeability, cause pulmonary edema, and can also promote neutrophils, and macrophage In ltration and release of cytotoxic enzymes aggravate lung injury [19] .…”

“…Compared with the S group, the expression of AnxA1 in the lung tissues of the I/R, D, A, and AL groups Discussion CPB-induced lung injury, one of the main complications after cardiovascular surgery, a dominant factor of postoperative death. 16 Studies have revealed that tumor necrosis and interleukin produced after CPB directly damage endothelial cells, increase capillary permeability, cause pulmonary edema, and promote infiltration of neutrophils and macrophage. The resulting release of cytotoxic enzymes aggravates lung injury.…”

Bilevel Positive Airway Pressure Versus Nasal Continuous Positive Airway Pressure for Prevention of Extubation Failure in Infants After Cardiac Surgery: A Randomized Controlled Trial

“…During pulmonary ischemiareperfusion, in ammatory cells in ltrate, pulmonary interstitial exudation increases, and microvilli on the surface of type II alveolar epithelial cells decrease in abundance. Therefore, patients are more likely to have complications such as alveolar collapse, atelectasis, acute respiratory failure, pulmonary infection, and so on [14,15]. At the same time, during invasive mechanical ventilation, alveolar mechanical ectasia and partial alveolar structure destruction cause lung injury and airway remodeling [16][17][18].…”

Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair

“…EPO was found to decrease pro-inflammatory cytokine production, including intercellular adhesion molecule-1 (ICAM-1) [46], interleukin-6 (IL-6) [47], and TNF-α [48,49]. EPO also increased the production of the anti-inflammatory cytokine IL-10 [48]. Additionally, EPO could increase endothelial nitric oxide synthase (eNOS) protein expression (Figure 1) [50], which increase nitric oxide production.…”

“…Hence, the potential anti-inflammatory effect of EPO has also been investigated. EPO was found to decrease pro-inflammatory cytokine production, including intercellular adhesion molecule-1 (ICAM-1) [46], interleukin-6 (IL-6) [47], and TNF-α [48,49]. EPO also increased the production of the anti-inflammatory cytokine IL-10 [48].…”