Effects of escitalopram and ibuprofen on a depression-like phenotype induced by chronic stress in rats

Seo, Mi Kyoung; Lee, Jung Goo; Park, Sung Woo

doi:10.1016/j.neulet.2018.12.033

Cited by 26 publications

(19 citation statements)

References 29 publications

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“…These results indicated again that LPS could be widely used to investigate the relationship between inflammation challenge and the impairment of neuropsychiatric behaviors including anxiety, depression, and memory deficit. As a common used NASID, the antidepressant effect of ibuprofen has been demonstrated in several animal models and human studies (Saleh et al, 2014;Kohler et al, 2015;Mesripour et al, 2019;Seo et al, 2019). Consistently, our results showed that treatment with ibuprofen could increase the rearing frequency and SPI of LPS-challenged rats, together with the decrease of immobility time in the FST.…”

Section: Discussionsupporting

confidence: 87%

“…Consistently, in our previous study (Ge et al, 2015a), administration with nesfatin-1 could induce depression-like behaviors, accompanied with the increased plasma concentrations of IL-6 and CRP. Moreover, the antidepressant-like effect of ibuprofen, which is one of the common used nonsteroidal anti-inflammatory drugs (NSAIDs), has demonstrated in animal studies (Mesripour et al, 2019;Seo et al, 2019). These findings support an overlapping pathobiology between inflammation and depression (Merali et al, 2003).…”

Section: Introductionmentioning

confidence: 69%

“…Hippocampus and prefrontal cortex (PFC) are key brain regions involved in the pathogenesis of depression and the antidepressant effects. Reduced serum BDNF levels, together with altered expression of BDNF and its highaffinity receptor tropomyosin receptor kinase B (TrkB) in the hippocampus and PFC, have been found in depression state and could be reversed by effective treatment with antidepressants (Gawali et al, 2016;Song et al, 2019;Seo et al, 2019). Results of our previous studies have suggested a positive relationship between the hippocampal expression of BDNF and Copine 6, synaptotagmin I, and synapsin I in stressed rats (Han et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC

Chen

et al. 2020

Front. Pharmacol.

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Quercetin is a polyphenol with multiple biological activities, and results of our preliminary study showed that it could shorten the immobility time of mice in the forced swimming test and tail suspending test. The aim of this study was to investigate its effects on the behavioral performance of lipopolysaccharide (LPS)-challenged rats and explore the potential mechanism. The results showed that intragastrical administration of quercetin (40 mg/kg) could improve the bodyweight gain of LPS-challenged rats, increase the saccharin preference index in the saccharin preference test and the novel arm preference index in the Y-maze, and decrease the immobility time in the FST. However, it showed no significant effect on the performance of LPS-challenged rats in the Morris water maze and the plasma concentrations of nesfatin-1, C-reactive protein (CRP), and IL-6. Results of western blot showed that the expression levels of BDNF, Copine 6, p-TrkB, and the triggering receptors expressed on myeloid cells (TREM) 1 were decreased in both the hippocampus and the prefrontal cortex (PFC) of LPS-challenged rats, while the expression of TREM2 was increased. The protein expression of synapsin-1 was decreased in the hippocampus without significant changes in the PFC. These imbalance protein expressions could be balanced by treatment with quercetin. The results suggested that quercetin could alleviate LPS-induced depression-like behaviors and impairment of learning and memory in rats, the mechanism of which might be involved with regulating the BDNF-related imbalance expression of Copine 6 and TREM1/2 in the hippocampus and the PFC.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

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Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC

Chen

et al. 2020

Front. Pharmacol.

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“…In this study, MS is associated with a reduction of hippocampal p11 expression at two time points in adulthood. Previous studies have demonstrated that chronic stress in adults induces p11 loss, as well as depression-like behaviors 22,23 . This study is the rst to show an association between ELS and p11 levels.…”

Section: Discussionmentioning

confidence: 99%

Early life stress induces age-dependent epigenetic changes in p11 gene expression

Seo¹,

Lee²,

Park³

2020

Preprint

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Early life stress (ELS) causes long-lasting changes in depression-like behaviors through epigenetic mechanisms. However, little is known about the effects of ELS in adulthood, specifically across different age groups. In this study, the epigenetic modifications of p11 expression in adult mice subjected to ELS were investigated in different stages of adulthood. Pups experienced maternal separation (MS) for 3 h daily from postnatal day 1 to 21. At young and middle adulthood, behavior phenotypes, hippocampal p11 expression levels, and levels of histone acetylation and methylation and DNA methylation at the hippocampal p11 promoter were measured. Middle-aged, but not young adult, MS mice exhibited depression-like behavior in the forced swimming test. Concurrent with reduced hippocampal p11 levels, mice in both age groups showed decreases in histone acetylation and activating histone methylation as well as increases in repressive histone methylation at the p11 promoter. The extent of the reduction in gene expression and histone acetylation was much higher in middle than in young adulthood. Moreover, DNA methylation analysis of the p11 promoter revealed increased CpG methylation in middle-aged MS mice only. The results highlight the age-dependent deleterious effects of ELS on depression-like behavior and on the epigenetic modifications of p11 transcription.

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“…It is known that the chronic stress (CS) increases the serum corticosterone levels resulting in physiological imbalances including male infertility (Arun et al., 2016; Seo et al., 2019; Zou et al., 2019). Previous reports showed that CS could reduce the testosterone level and sperm quality (Juárez‐Rojas et al., 2015; Ribeiro et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Chronic stress affects tyrosine phosphorylated protein expression and secretion of male rat epididymis

et al. 2021

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Chronic stress (CS) is shown to decrease the semen quality with changed expression of tyrosine phosphorylated (TyrPho) proteins in testicular and seminal tissues. However, the alterations of such proteins and fluid contents in the epididymis, producing sperm maturation factors, have never been reported. Sixteen adult rats were randomly divided into 2 groups (n = 8). The control animals were not subjected to stressors whereas CS rats were immobilised within restraint cage (4 hr/day) before cold forced‐water swimming (15 min/day) for 60 days. Corticosterone, testosterone, blood glucose level (BGL), malondialdehyde (MDA) and biochemical components in epididymal fluid were assayed. Expressions of heat shock protein 70 (HSP‐70), androgen receptor (AR) and TyrPho protein were investigated in epididymal tissue and fluid. Significantly, CS increased the corticosterone and BGL but decreased testosterone and epididymal substance levels. MDA level in tail epididymal fluid and HSP‐70 expression in both regions of epididymal tissues and fluids, except in head epididymal fluid of CS were increased. Epididymal tissues showed the decrease of AR expression. Presence and changes of many TyrPho proteins were observed in CS. In conclusion, CS could affect functional proteins particularly TyrPho in epididymis, resulted in low semen quality.

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Effects of escitalopram and ibuprofen on a depression-like phenotype induced by chronic stress in rats

Cited by 26 publications

References 29 publications

Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC

Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC

Early life stress induces age-dependent epigenetic changes in p11 gene expression

Chronic stress affects tyrosine phosphorylated protein expression and secretion of male rat epididymis

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