Effects of Escitalopram on C reactive protein in patients of depression

Chittora, Gaurav; Rastogi, Pali; Razdan, Ramghulam; Songara, Prafulla

doi:10.17511/ijmrr.2017.i02.11

Cited by 2 publications

(2 citation statements)

References 15 publications

(10 reference statements)

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“…In our study the baseline hsCRP level was significantly lower in responders when compared to non-responders, that is, patients with low hsCRP levels tended to respond better to SSRIs. This was in accordance with a few studies which revealed that increased CRP was indicative of a poorer treatment response to antidepressant therapy [51‒53, 56, 57]. This suggests that hsCRP can be a desirable marker which can be used to predict response to SSRIs.…”

Section: Discussionsupporting

confidence: 91%

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Association of Serum Biomarker Levels and BDNF Gene Polymorphism with Response to Selective Serotonin Reuptake Inhibitors in Indian Patients with Major Depressive Disorder

et al. 2020

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Introduction: Depression is a major public health problem. Response to selective serotonin reuptake inhibitor (SSRI) treatment varies considerably between patients. In the context of polygenic diseases like depression, measurement of a panel of biomarkers involved in the pathophysiology of depression might help predict outcome to treatment with SSRIs. Objective: The objective was to establish the relationship between serum biomarker levels and the brain-derived neurotrophic factor (BDNF) val66met polymorphism and response to SSRIs in patients with major depressive disorder. Methods: 50 patients with moderate to severe depression were recruited from the Department of Psychiatry, Sri Ramachandra Institute of Higher Education and Research. Blood samples were collected, and Hamilton Depression Rating Scale scoring was done at baseline and after 8 weeks of treatment with SSRIs. Baseline and post-treatment levels of high-sensitivity C-reactive protein (hsCRP), BDNF and neuregulin 1β1 (NRG1β1) were analysed using commercially available ELISA kits. Genotyping of the BDNF Val66Met polymorphism was performed using a PCR-RFLP method. Results: Following treatment, there was a significant decrease in the mean hsCRP and NRG1β1 levels and a significant increase in the mean BDNF level. Responders had significantly lower baseline hsCRP and higher baseline BDNF levels when compared to non-responders. Response rates were significantly higher in the Val/Val group when compared to the Val/Met group. Conclusions: Baseline serum levels of hsCRP and BDNF predicted response to SSRIs in major depressive disorder, and Val/Val patients responded better when compared to patients carrying the Met allele.

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Section: Discussionsupporting

confidence: 91%

“…Hence, pretreatment hsCRP levels predicted response to SSRIs. In addition to a similar outcome, a study also found a positive correlation between baseline HAM-D score and baseline CRP [57], but we found no significant association between baseline hsCRP and severity of depression nor duration of illness.…”

Section: Discussionsupporting

confidence: 72%

Association of Serum Biomarker Levels and BDNF Gene Polymorphism with Response to Selective Serotonin Reuptake Inhibitors in Indian Patients with Major Depressive Disorder

et al. 2020

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Movie Recommendation System Using Machine Learning

Arokiaraj

Sandeep

Vishnu

et al. 2023

IoT, Cloud and Data Science

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There are more number of movies has been released the user gets confusion, which movie is suit for them and difficult to choose, so to become easier the recommendation system comes into play if the user search a movie it gives a accurate result with similar various suggestion . The suggestion movies are given by the recommendation system by the user search e.g., if the movie is action, love, crime, drama or by the director the similar movies will be suggested. The recommendation systems are used to recommend movies using the user previews choice. The Sentiment Analysis which helps to analyse the users sentiments, which is based on their choice.In recent year, the sentimental analysis became one of most major things for many of the recommendation systems

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Effects of Escitalopram on C reactive protein in patients of depression

Cited by 2 publications

References 15 publications

Association of Serum Biomarker Levels and BDNF Gene Polymorphism with Response to Selective Serotonin Reuptake Inhibitors in Indian Patients with Major Depressive Disorder

Association of Serum Biomarker Levels and BDNF Gene Polymorphism with Response to Selective Serotonin Reuptake Inhibitors in Indian Patients with Major Depressive Disorder

Movie Recommendation System Using Machine Learning

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