Effects of Esomeprazole on Sleep in Patients with Gastroesophageal Reflux Disease as Assessed on Actigraphy

Abstract

Objective Gastroesophageal reflux disease (GERD) is strongly associated with sleep disturbances. Although treatment with proton pump inhibitors (PPIs) helps to improve GERD symptoms and subjective sleep parameters, the effects of PPI therapy on objective sleep parameters are conflicting. The aim of this study was to examine the effects of esomeprazole treatment on GERD symptoms and sleep parameters assessed using actigraphs and questionnaires. Methods Thirteen patients with GERD received 20 mg of esomeprazole once daily for two weeks. The patients wore actigraphs from three days before the initiation of PPI treatment to the end of therapy. They were also asked to answer the following self-reported questionnaires: Frequency Scale for the Symptoms of GERD (FSSG), Pittsburg Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). Objective sleep parameters were evaluated using actigraphy. Results Treatment with esomeprazole significantly decreased the total FSSG score, including the scores for reflux and dysmotility, as well as the ESS score, although it had no effect on the PSQI score. After the second week of treatment, esomeprazole significantly decreased the wake time (from 47.5±39.6 min to 36.0± 27.1 min) and sleep latency period (from 19.5±19.8 min to 9.9±10.2 min) and increased the percentage of sleep time (from 89.1±8.8% to 91.9±6.3%); however, improvements were not noted in all objective parameters. Conclusion Esomeprazole treatment significantly improves various objective sleep parameters in Japanese patients with GERD. Further placebo-controlled randomized trials are needed to obtain detailed results.

Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients

“…This study also reported that daily treatment with rabeprazole for 8 weeks decreased sleep disorders. However, Hiramoto et al ( 20 ) reported that once-daily treatment with esomeprazole for 2 weeks decreased GERD symptoms, but did not decrease sleep disorders. Whether the sleep disorders of partial responders can be improved by PPI therapy alone is a subject for future analysis.…”

Gastroesophageal reflux disease: recent advances and its association with sleep

“…In a previous study, PPI treatment improved objective sleep parameters. Actigraphy, which is an ambulatory device, recorded motion in 13 GERD patients and showed that esomeprazole 20 mg increased the percentage of sleep time and decreased the wake time and sleep latency period; however, it failed to show progress in all objective sleep parameters …”

“…Actigraphy, which is an ambulatory device, recorded motion in 13 GERD patients and showed that esomeprazole 20 mg increased the percentage of sleep time and decreased the wake time and sleep latency period; however, it failed to show progress in all objective sleep parameters. 55 Several studies have investigated the association of GERD with nGER and sleep disturbances. PPI treatment has been shown to improve GERD-related sleep disturbances.…”