Effects of estrogen and progestin replacement on the urogenital tract of the ovariectomized cynomolgus monkey

Robinson, Deirdre; Rainer, Robert; Washburn, Scott A.; Clarkson, Thomas B.

doi:10.1002/(sici)1520-6777(1996)15:3<215::aid-nau6>3.0.co;2-i

Cited by 29 publications

(8 citation statements)

References 13 publications

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“…(13) The role of estradiol in target tissues in the lower urinary tract remains unclear. It has been postulated that estrogen may increase loose connective tissue and/or stimulate collagen degradation in the pelvic and urethral tissue [17,24,25]. It could be speculated that this could result in an increased hypermobility of the bladder neck and the paraurethral tissue leading to an impaired urethral closure function [13].…”

Section: Commentsmentioning

confidence: 99%

Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study

Hamer

Källén

Lidfeldt

et al. 2011

European Journal of Obstetrics & Gynecology and Reproductiv

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Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study.Andrada, Maria; Källén, Karin; Lidfeldt, Jonas; Samsioe, Göran; Teleman, Pia General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. We believe the majority of urgency symptoms in perimenopausal women to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck. If this is the case, there would be no difference in estradiol levels between the groups. Study design:Setting: university hospital. In the observational Women´s Health In the Lund Area study, a subset of 400/2221 women reporting urinary incontinence completed a detailed questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone levels measured.Statistical analyses were made by Chi-square test, nonparametrical tests, ANOVA, multi-and univariate logistic regression analysis. Results:Stress incontinence was reported by 196, mixed incontinence by 153 and urge incontinence by 43 women. Serum estradiol did not differ significantly between stress incontinent (median 49.5 pmo/l, range 2.63-875.4), urge incontinent ( median 31.6 pmol/l, range 2.63-460.7) or mixed incontinent women ( median 35.5 pmol/l, range 2.63-787.9, p = 0.62). Logistic regression analysis correcting for age, parity, hormonal status, smoking, hysterectomy and BMI also failed to show any difference in estradiol levels between the groups (p=0.41-0.58). Conclusion:No significant differences in serum estradiol levels between stress, mixed or urge incontinent perimenopausal women could be demonstrated . 4Keywords:Female urinary incontinence; mixed urinary incontinence; serum estradiol; stress urinary incontinence; urge urinary incontinence.5

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Section: Commentsmentioning

confidence: 99%

Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study

Hamer

Källén

Lidfeldt

et al. 2011

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Menopause was responsible for inducing a reduction in the number of vaginal epithelial layers, and loss of intermediate cells, represented by an overall reduction in epithelial height [20]. Laboratory studies, showed that ovariectomized rabbits, rats, and nonhuman primates had significant decrease in vaginal epithelial height and smooth muscle tissues [5,6,19,21].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, estrogens can enhance genital sensation and maintain blood flow [4]. Previous studies on ovariectomized animals revealed a significant reduction in vaginal epithelial height and smooth muscle tissues [5,6]. E-cadherin is one of the cadherin protein groups, which is responsible for cell to cell adhesion of epithelial cells, morphogenesis, and tissue organization.…”

Section: Introductionmentioning

confidence: 99%

Restoration of Vaginal Epithelial Atrophy in Ovariectomized Rats with Sex Steroid Hormones

Abdel-Aal

Abdel-Hamid

Selim

2015

MOJAP

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Histological and immunohistochemical changes in vaginal tissue structure of ovariectomized rats were assessed in response to sex steroid hormone administration. Sixty female rats were divided into six groups (10) each; control, sham, ovariectomized, ovariectomized rats treated with estradiol (20 µg/kg/day), Ovariectomized rats treated with progesterone (1 mg/kg/day) and ovariectomized rats treated with both estradiol and progesterone. Vaginal tissues were examined through haematoxylin and eosin, masson trichrome, and periodic acid shiff stains. Immunohistochemistry was used for expression of E-cadherin in vaginal epithelial cells. Ovariectomized rats with or without progesterone administration revealed a significant decrease in vaginal weight and length, reduction of vaginal epithelial thickness and glycogen content, which were restored with estradiol administration. Percent area of collagen fibers was not affected in all groups. E-cadherin expression was decreased in vaginal epithelium of both ovariectomized rats and progesterone administered group. It was concluded that vaginal epithelial atrophy due to ovariectomy can be restored by administration of estradiol or in combination with progesterone.

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“…Eine oft zitierte Metaanalyse der klinischen Ergebnisse ist jene von Fantl et al [6,7], in der 77 Publikationen zu diesem Thema zusammengefasst und analysiert wurden. Die Autoren fanden eine signifikante Besserung der klinisch fassbaren Beschwerden sowohl unter Verabreichung von Östriol als auch von Östradiol, wobei das Maximum des Effekts zwischen dem ersten und dritten Therapiemonat zu verzeichnen war, und zwar unabhängig davon, ob der Hormonersatz vaginal, perkutan oder oral durchgeführt worden war.Auch neueste Untersuchungen scheinen dies zu bestätigen [12,13,18,25], wobei die Kombination von oraler Hormonersatztherapie mit zusätzli-cher vaginaler Östriolzufuhr die besten Resultate zeitigt.…”

Section: öStrogeneunclassified

“…Die meisten Gestagene sind Testosteronderivate und besitzen zudem eine mehr oder minder ausgeprägte partielle androgene Aktivität. Immerhin scheint sich ein Progesteronzusatz zur Östrogensubstitution -obligat bei allen nicht hysterektomierten Frauen -wenigstens nicht negativ auf die urogenitalen Symptome und den Prolaps auszuwirken [13,18,25], obwohl Gestagene auf die Genitalmukosa insgesamt eine atrophisierende Wirkung ausüben.…”

Section: Gestageneunclassified

Einfluss von Hormonen auf den Beckenboden

Maurer-Major

2001

coloproctology

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Effects of estrogen and progestin replacement on the urogenital tract of the ovariectomized cynomolgus monkey

Cited by 29 publications

References 13 publications

Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study

Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study

Restoration of Vaginal Epithelial Atrophy in Ovariectomized Rats with Sex Steroid Hormones

Einfluss von Hormonen auf den Beckenboden

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