Effects of Estrogen Deficiency and/or Caffeine Intake on Alveolar Bone Loss, Density, and Healing: A Study in Rats

Bezerra, Joyce Pinho; Siqueira, Ariane de; Pires, Amanda Goncxalves; Marques, Marcelo Rocha; Duarte, Poliana Mendes; Bastos, Marta Ferreira

doi:10.1902/jop.2012.120192

Cited by 37 publications

(38 citation statements)

References 50 publications

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“…The most novel finding of the current study was the observation of the benefits of strontium ranelate on alveolar bone under estrogen deficiency. In agreement with previous studies, estrogen deficiency significantly increased the ligature‐induced BL. Strontium ranelate limited the ligature‐induced BL in the estrogen‐deficient animals at all experimental times and, to some extent, to an even greater magnitude than in the estrogen‐sufficient animals.…”

Section: Discussionsupporting

confidence: 93%

Effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats

Marins

Napimoga

Malta

et al. 2019

J of Periodontal Research

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Background and objectives Strontium ranelate is a medication indicated for the treatment of osteoporosis that presents concomitant anti‐resorptive and osteoanabolic dual biological activity. However, the effects of strontium ranelate on alveolar bone have been poorly explored. Furthermore, to date, there are no data on the effects of this medication on alveolar bone loss (BL) during conditions of estrogen deficiency. Therefore, the aim of this study was to evaluate the effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats. Methods Ninety‐six rats were assigned to one of the following groups: sham‐surgery + water (estrogen‐sufficient; n = 24); ovariectomy + water (estrogen‐deficient; n = 24), sham‐surgery + strontium ranelate (ranelate/estrogen‐sufficient; n = 24) and; ovariectomy + strontium ranelate (ranelate/estrogen‐deficient; n = 24). The rats received strontium ranelate or water from the 14th day after ovariectomy until the end of the experiment. On the 21st day after ovariectomy, one first mandibular molar received a ligature, while the contralateral tooth was left unligated. Eight rats per group were killed at 10, 20, and 30 days after ligature placement. Bone loss (BL) and trabecular bone area (TBA) were analyzed in the furcation area of ligated and unligated teeth at all experimental times by histometry. Tartrate‐resistant acid phosphatase (TRAP) positive cells and immunohistochemical staining for osteocalcin (OCN), osteopontin (OPN), osteoprotegerin (OPG), and receptor activator of NF‐КB ligand (RANKL) were assessed in the ligated teeth at 30 days after ligature placement. Results At 10 and 30 days, ligated teeth of the estrogen‐deficient group exhibited higher BL, when compared to all other groups (P < .05). At 10 days, TBAs were higher in the unligated teeth of strontium ranelate‐treated groups, when compared to those of untreated groups (P < .05). At 30 days, the ligated teeth of the estrogen‐deficient group exhibited lower TBA than the other groups (P < .05). There were no differences among groups regarding the number of TRAP‐stained cells (P < .05). The strontium ranelate‐treated groups exhibited lower expressions of OCN and RANKL than the untreated groups (P < .05). The estrogen‐sufficient group presented higher staining for OPG than both treated and untreated estrogen‐deficient groups (P < .05). Conclusions Strontium ranelate prevented ligature‐induced BL in an estrogen‐deficiency condition and, to a certain extent, increased TBA in the presence and absence of periodontal collapse in states of estrogen deficiency and estrogen sufficiency. Furthermore, strontium ranelate also affected the expression of bone markers, appearing to have acted predominantly as an anti‐resorptive agent.

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Section: Discussionsupporting

confidence: 93%

Effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats

Marins

Napimoga

Malta

et al. 2019

J of Periodontal Research

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“…Estrogen deficiency results in loss of maxillary bone [8], [9], and estrogen receptor α is required to maintain the microarchitecture of the maxillary alveolar bone [10]. Estrogen is also reported to be an important regulator of cartilage homeostasis, growth and maturation [11], and controls the growth and closure of the epiphyseal plate [12].…”

Section: Discussionmentioning

confidence: 99%

Orthognathic surgery during breast cancer treatment—A case report

Shimo

Yoshioka

Nakamura

et al. 2017

International Journal of Surgery Case Reports

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HighlightsIn recent years, patients with orthognathic surgery in middle-aged have come to be a more frequent occurrence.Breast cancer is the most frequently diagnosed cancer in woman worldwide, and its prevalence rate is steadily increasing.We experienced a case in which breast cancer was found just before the orthognathic surgery we performed a bimaxillary osteotomy, including follow-up tamoxifen administration, during breast cancer treatment.We performed a bimaxillary osteotomy, including follow-up tamoxifen administration, during breast cancer treatment.

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“…While some studies have suggested that the effects of coffee/caffeine on bone metabolism are still controversial (6), others have reported that caffeine, a major constituent of coffee, is associated with a significant increase of periodontal diseases (7), fracture of osteoporotic bones (8), increase in urinary calcium and decrease of bone mineral density (6), as well as delay in bone repair process (9). Also, caffeine has an additional deleterious effect when administrated to animals with osteoporotic bones (10).…”

Section: Introductionmentioning

confidence: 99%

Effects of Coffee Intake and Intraperitoneal Caffeine on Bone Repair Process - A Histologic and Histometric Study

2015

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Studies have suggested that caffeine acts on bone promoting an increase of calcium excretion, inhibition of osteoblast proliferation and delay in tissue repair process, raising the risk of fractures, osteoporosis, periodontal disease and affecting the success of bone reconstructive procedures. The aim of this study was to analyze histomorphometrically the process of alveolar bone healing after tooth extraction in rats subjected to daily intake of boiled coffee or intraperitoneal administration of caffeine. Forty-five male rats were divided according to the treatment in Control group (C); Coffee group (CO) -treated with coffee since birth; and Caffeine (CAF) -intraperitoneal injection of aqueous solution of caffeine 1.5% (0.2 mL/100g body weight) for 30 days. When weighing between 250-300 g they were anesthetized, subjected to extraction of the maxillary right incisor, and euthanized 7, 21 and 42 days after surgery for histological assessments of bone volume and the quality of formed bone in the dental socket. The qualitative results demonstrated larger amounts of blood clot and immature bone in animals under treatment of pure caffeine compared to coffee and control. Histometric analysis revealed that coffee treatment led to a 40% drop in bone formation, and caffeine a 60% drop in comparison to control animals (ANOVA p≤0.01). It was concluded that both the daily ingestion of coffee and the intraperitoneal administration of caffeine in rats delayed the alveolar bone reparative process after tooth extraction, and this effect was more aggressive when pure caffeine was used.E f f e c t s o f C o f f e e I n t a k e a n d I n t r a p e r i t o n e a l C a f f e i n e o n B o n e R e p a i r P r o c e s s -A

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Effects of Estrogen Deficiency and/or Caffeine Intake on Alveolar Bone Loss, Density, and Healing: A Study in Rats

Abstract: Caffeine increased BL in ligated teeth. Caffeine and/or estrogen deficiency decreased TBA in the unligated teeth and reduced BH after tooth extraction.

Cited by 37 publications

References 50 publications

Effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats

Effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats

Orthognathic surgery during breast cancer treatment—A case report

Effects of Coffee Intake and Intraperitoneal Caffeine on Bone Repair Process - A Histologic and Histometric Study

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