Effects of Estrogens on Osteoimmunology: A Role in Bone Metastasis

Marie, Julien C.; Bonnelye, Edith

doi:10.3389/fimmu.2022.899104

Cited by 6 publications

(2 citation statements)

References 112 publications

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“…Additionally, a growing number of studies have shown that bone mass loss in OVX animal models is always accompanied by the abnormal accumulation of BMAT [ 11 , 40 , 41 ]. Estrogen supplementation results in an increase in bone mass and decrease in bone fat in estrogen-deficient humans and mice [ 15 , 42 ]. These results demonstrate that BMAT is associated with bone loss caused by estrogen loss.…”

Section: Postmenopausal Bone Marrow Adiposity and Fatty Acid Metaboli...mentioning

confidence: 99%

Common Regulators of Lipid Metabolism and Bone Marrow Adiposity in Postmenopausal Women

Kim¹,

Ko²

2023

Pharmaceuticals

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A variety of metabolic disorders are associated with a decrease in estradiol (E2) during natural or surgical menopause. Postmenopausal women are prone to excessive fat accumulation in skeletal muscle and adipose tissue due to the loss of E2 via abnormalities in lipid metabolism and serum lipid levels. In skeletal muscle and adipose tissue, genes related to energy metabolism and fatty acid oxidation, such as those encoding peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) and estrogen-related receptor alpha (ERRα), are downregulated, leading to increased fat synthesis and lipid metabolite accumulation. The same genes regulate lipid metabolism abnormalities in the bone marrow. In this review, abnormalities in lipid metabolism caused by E2 deficiency were investigated, with a focus on genes able to simultaneously regulate not only skeletal muscle and adipose tissue but also bone metabolism (e.g., genes encoding PGC-1α and ERRα). In addition, the mechanisms through which mesenchymal stem cells lead to adipocyte differentiation in the bone marrow as well as metabolic processes related to bone marrow adiposity, bone loss, and osteoporosis were evaluated, focusing on the loss of E2 and lipid metabolic alterations. The work reviewed here suggests that genes underlying lipid metabolism and bone marrow adiposity are candidate therapeutic targets for bone loss and osteoporosis in postmenopausal women.

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Section: Postmenopausal Bone Marrow Adiposity and Fatty Acid Metaboli...mentioning

confidence: 99%

Common Regulators of Lipid Metabolism and Bone Marrow Adiposity in Postmenopausal Women

Kim¹,

Ko²

2023

Pharmaceuticals

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“…BC with BM frequently causes skeletal-related events. This is because breast cancer cells enter the bone marrow through interactions with endothelial cells and osteoblasts, disrupting the balance between osteoclasts and osteoblasts, affecting bone homeostasis, and subsequently leading to skeletal dysfunction, such as spinal cord compression, pathological fracture osteosclerosis, osteoporosis, osteoarthritis (7,8). As a result, patients' median survival time was reduced to 24-55 months following BM diagnosis (9,10).…”

Section: Introductionmentioning

confidence: 99%

Risk stratification system and visualized dynamic nomogram constructed for predicting diagnosis and prognosis in rare male breast cancer patients with bone metastases

Gao

et al. 2022

Front. Endocrinol.

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BackgroundBone metastases (BM) from malignant tumors could disrupt the balance between osteoclasts and osteoblasts and affect bone homeostasis. Malignant breast cancer (BC) is rare in male patients, and co-occurrence of BM is even rarer. Given its low incidence, there is limited research evaluating risk and prognosis. Despite the widespread application of nomograms to predict uncommon malignancies, no studies have constructed predictive models focusing on the diagnosis and prognosis of male breast cancer with bone metastases (MBCBM).MethodsThis study selected all male breast cancer patients (MBC) between 2010 and 2019 in the Surveillance, Epidemiology, and End Results (SEER) database. We used simple and multivariate Logistic regression analyses to identify independent risk factors for BM in MBC patients. Then simple and multivariate Cox regression analyses were employed to determine the independent prognostic factors for overall survival (OS) and cancer-specific survival (CSS) in MBCBM patients. We established and validated three new nomograms based on these independent factors.ResultA total of 4187 MBC patients were included, with 191 (4.56%) having bone metastases at the time of diagnosis. The independent risk factors of BM in MBC patients included age, tumor size, marital status, T stage, and N stage. In MBCBM patients, independent prognostic factors for OS and CSS were both age, T stage, ER status, PR status, and surgery. The concordance index (C-index), the area under the curve (AUC) of the receiver operating characteristic curve (ROC), the calibration curve, and the decision curve analysis (DCA) confirmed that these three nomograms could accurately predict the diagnosis and prognosis of MBCBM patients with excellent discrimination and clinical utility superior to the TNM staging system. We then established two prognostic-based risk stratification systems and three visualized dynamic nomograms that could be applied in clinical practice.ConclusionIn conclusion, this study aimed to establish and validate an accurate novel nomogram to objectively predict the diagnosis and prognosis of MBCBM patients. On this basis, prognostic-based risk stratification systems and visualized dynamic nomograms were constructed to facilitate doctors and patients to quantify individual BM risk probability and survival probability to assist in personalized risk assessment and clinical decision-making.

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Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease

Ullah,

Chen,

Singla

et al. 2024

Ageing Research Reviews

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Effects of Estrogens on Osteoimmunology: A Role in Bone Metastasis

Cited by 6 publications

References 112 publications

Common Regulators of Lipid Metabolism and Bone Marrow Adiposity in Postmenopausal Women

Common Regulators of Lipid Metabolism and Bone Marrow Adiposity in Postmenopausal Women

Risk stratification system and visualized dynamic nomogram constructed for predicting diagnosis and prognosis in rare male breast cancer patients with bone metastases

Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease

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