Effects of etanercept on sodium taurocholate-induced acute pancreatitis in rats

Yılmaz, Mustafa; Topsakal, Şenay; Herek, Özkan; Özmen, Özlem; Şahinduran, Şima; Büyükoğlu, Tülay; Yönetçi, Nadir

doi:10.1016/j.trsl.2009.07.009

Cited by 17 publications

(23 citation statements)

References 32 publications

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“…However in the etanercept treated burn groups, MPO activities were decreased suggesting that the protective effect of this agent in burn-induced lung injury involves the inhibition of neutrophil infiltration to the tissues. Similarly in the rats with acute pancreatitis, etanercept treatment reducing MPO activity decreased caspase positive cell numbers and ameliorated acute necrotic pancreatitis (29).…”

Section: Discussionmentioning

confidence: 83%

Etanercept protects remote organ damage in a rat model of thermal injury

Şehirli¹

2011

mpj

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Section: Discussionmentioning

confidence: 83%

Etanercept protects remote organ damage in a rat model of thermal injury

Şehirli¹

2011

mpj

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“…Recent studies have shown that TNF-> inhibition significantly ameliorates the course of experimental AP. 9,12 To our knowledge, the effects of pharmacological TNF-> inhibition by means of ADA have not been investigated in experimental pancreatitis so far. The aim of this study was to investigate the therapeutic effectiveness of ADA on experimentally 3% sodium (Na)YtaurocholateYinduced AP in rats.…”

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confidence: 99%

Ameliorative Effect of Adalimumab on Experimentally Induced Acute Pancreatitis in Rats

Yılmaz¹,

Tekekoglu²,

Herek³

et al. 2010

Pancreas

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“…Also, the activity of mpo seems to be lower in the groups 4, 5 and 6 received treatments than those of acute pancreatitis groups. In an experimental study, Yılmaz et al (2009) reported that etanercept caused marked decreases in pancreatic tissue MDA levels and mpo activities in treated groups with taurocholate-induced acute pancreatitis. In according to these findings, TNF-α reduction by etanercept might lead to ameliorate pancreatic oxidative stress in AP.…”

Section: Discussionmentioning

confidence: 99%

The Combined Effects of Etanercept Plus Methylprednisolone on Pancreatic Oxidative Stress in Acute Pancreatitis Induced by Cerulein

Günay¹,

Kılıç²,

AMANVERMEZ³

2011

jecm

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KeywordsEtanercept Methylprednisolone Acute pancreatitis Oxidative stress Malondialdehyde Protein carbonyls ARTICLE INFO ABSTRACTWhether etanercept plus metylprednisolone reduce pancreatic oxidative stress and injury during pancreatitis is unknown well. The aim of this study was to examine the therapeutic effects of etanercept and methylprednisolone (MP) on acute pancreatitis and oxidative stress in acute pancreatitis (AP) induced by cerulein in a rat model. The study was performed with 48 rats divided into 6 groups (n = 8/group): 1-sham, 2-cerulein-induced pancreatitis (over 10 hours), 3-cerulein-pancreatitis (over 20 hours), 4-etanercept (5 mg/ kg, i.p.), 5-methylprednisolone (10 mg/kg, i.m.), 6-etanercept plus methylprednisolone. Also, the rats in groups 4, 5, and 6 were cerulein-induced pancreatitis at 20 hours. After the treatment, the pancreas and blood were taken for histopathological and biochemical analysis. All cerulein-treated rats developed biochemical and pathological acute pancreatitis after 10-20 hours. The markers of oxidative stress such as protein carbonyls, lipid peroxidation, and myeloperoxidase (mpo) in the pancreas tissues were increased in the group 2 and 3, but these were lower in etanercept and MP-treated rats compared to groups 3. Pancreatic mpo activity was considerably reduced in pancreas tissues at 20 h after the administration of etanercept plus metylprednisolone in the group 6 compared to group 3. In AP induced by cerulein, the treatment of etanercept plus methylprednisolone may ameliorate pancreatic oxidative stress in rats.

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Effects of etanercept on sodium taurocholate-induced acute pancreatitis in rats

Cited by 17 publications

References 32 publications

Etanercept protects remote organ damage in a rat model of thermal injury

Etanercept protects remote organ damage in a rat model of thermal injury

Ameliorative Effect of Adalimumab on Experimentally Induced Acute Pancreatitis in Rats

The Combined Effects of Etanercept Plus Methylprednisolone on Pancreatic Oxidative Stress in Acute Pancreatitis Induced by Cerulein

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