Effects of ethanol extract of &lt;i&gt;Tridax procumbens&lt;/i&gt; on spermiogram and reproductive hormones in Wistar rat

Akintunde, OG; Oloye, AA; Adetomiwa, AS; Subuloye, WO; Olaiya, Charles O.

doi:10.4314/sokjvs.v15i3.4

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…Powdered leaves of Tridax procumbens were macerated with 70% ethanol for 48 hours. Macerate was filtered using Whatman filter paper followed by evaporation to obtain semi solid extract 10 . Powdered leaves of Euphorbia hirta Linn were cold macerated with ethanol for 72 hours.…”

Section: Preparation Of Leaf Extractsmentioning

confidence: 99%

“…It is also used as an anticoagulant and antifungal agent 9 . Tridax procumbens is a potent source of antioxidants which helps in treating wounds and related infections 10 . Euphorbia hirta Linn is a small annual herb belonging to the family Euphorbiaceae.…”

Section: Introductionmentioning

confidence: 99%

“…Leaf extracts of these three plants are rich in alkaloids, flavonoids, tannins, saponins, terpenes, carotenoids and essential oils, which impart good antioxidant potential to these plants. Due to diverse pharmacological properties and their easy availability, these plant products are selected for preparation of newer polyherbal formulation in this study 7,8,9,10,11 .…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Newer Poly Herbal Formulations for Wound Healing and Anti-Inflammatory Activity

Soujanya¹,

Mazin²,

Teja³

et al. 2022

Int. Res. J. Pharm.

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According to Herbalism, independent medicinal herbs are not sufficient to obtain the required pharmacological effect, but when we use these herbal compounds in combination at appropriate proportions will help to obtain maximum pharmacological effects with minimal toxic effects. In this present study, efforts were made to develop an intervention with a poly herbal formulation which was prepared from ethanolic leaf extracts of Chromolaena odorata, Tridax procumbens, Euphorbia hirta Linn. The impact of poly herbalism is assessed for its wound healing property by using excision wound model and anti-inflammatory property by using formalin induced paw oedema model. For wound healing assessment two polyherbal formulations F1 and F2 are prepared with 2% and 4% W/W. These formulations were examined for stability studies. F1(*p<0.005) and F2 (**p<0.001) have shown significant wound closure and faster epithelialisation when compared to standard Povidone-Iodine (5%) ointment (**p<0.001). For assessing anti-inflammatory activity, the poly herbal formulations are prepared as 2% (F1) and 4% (F2) solutions. The doses from each formulation are given as 100 mg/kg, 200 mg/kg and 300 mg/kg to different groups of animals. Both the poly herbal formulations have shown significant results F1(*p<0.05, **p<0.005) and F2 (***p<0.0005, ****p<0.0001) respectively when compared to standard Indomethacin 4 mg/kg dose (****p<0.0001). This study has revealed that poly herbal formulations have shown better anti-inflammatory and wound healing properties due to the synergism of the phytochemicals present in these plant extracts which may lead to future developments of potential poly herbal formulations in the treatment of wounds and inflammatory mediated diseases.

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Section: Preparation Of Leaf Extractsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Newer Poly Herbal Formulations for Wound Healing and Anti-Inflammatory Activity

Soujanya¹,

Mazin²,

Teja³

et al. 2022

Int. Res. J. Pharm.

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“…Vitamin C, a synthetic antioxidant, has been reported to attenuate chronic variable stressinduced ED 14 . Several reports have shown that Tridax procumbens has potent antioxidant properties [15][16][17][18] . Tridax procumbens leaf extract has shown potential in attenuating erectile dysfunction in experimental hypertensive and paroxetine-induced rats.…”

Section: Introductionmentioning

confidence: 99%

Tridax procumbens leaf antioxidants and hormonal activity ameliorate variable stress-induced erectile and reproductive impairments in Wistar rats

Ademola,

Irenemarie,

Olabode

et al. 2023

Biomed. Res. Ther.

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Introduction:The role of Tridax procumbens leaf extract in erectile dysfunction (ED) of chronic variable stress (CVS) etiology is unknown. This study investigates the potential of the ethanol fraction of Tridax procumbens leaf (EETP) in modulation of CVS-induced ED. Methods: Twenty-five male Wistar rats were divided into five groups of five rats each. Groups 1 & 2 (without stress) were treated with normal saline (vehicle) and 100 mg/kg of EETP, respectively. Groups 3-5 were treated as stress groups, with Group 3 co-treated with 100 mg/kg of EETP, and group 4 co-treated with vitamin C (7 mg/kg). Treatments were administered by oral gavage once daily for seven weeks. Oxidative biomarkers, cortisol, testosterone, and sperm parameters were determined, as well as the contractile mechanism of the corpus cavernosa to cumulative doses of calcium chloride, potassium chloride, acetylcholine, and sodium nitroprusside. Furthermore, the contractile mechanism was also determined after incubation in acetovanillone, nicorandil, methyl blue, and glibenclamide. Results: Serum cortisol was significantly reduced, while testosterone was significantly increased in the EETP supplemented groups when compared to the CVS-only exposed group. Furthermore, malonaldehyde activity was decreased while superoxide dismutase concentration was increased in the EETP-and vitamin C-supplemented groups when compared to the CVS-only exposed group. Contraction (%) responses to calcium chloride and potassium chloride were also significantly reduced in the CVS-only exposed group when compared to the EETP-supplemented groups. The relaxation responses (%) to acetylcholine and SNP were significantly increased in the CVS group supplemented with EETP and vitamin C when compared to the CVS-only exposed group. The incubation of the cavernosa tissues in acetovanillone and nicorandil resulted in increased relaxation (%) in the CVS-only group, while incubation in glibenclamide caused increased relaxation in the EETPsupplemented groups compared to CVS-only exposed group. Sperm motility (%) was significantly reduced while abnormal spermatozoa was increased in the CVS-only exposed group when compared to the groups supplemented with EETP and Vitamin C. Conclusion: Variable stress-induced dysfunctions in erectile mechanism were attenuated through supplementation with EETP.

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Effect of Tridax procumbens extracts on coagulation time according to gender and blood groups A and O: in vitro study

Alshargabi,

Mansour,

Al-Madhagi

2023

Journal of Herbal Medicine

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Effects of ethanol extract of <i>Tridax procumbens</i> on spermiogram and reproductive hormones in Wistar rat

Cited by 4 publications

References 8 publications

Evaluation of Newer Poly Herbal Formulations for Wound Healing and Anti-Inflammatory Activity

Evaluation of Newer Poly Herbal Formulations for Wound Healing and Anti-Inflammatory Activity

Tridax procumbens leaf antioxidants and hormonal activity ameliorate variable stress-induced erectile and reproductive impairments in Wistar rats

Effect of Tridax procumbens extracts on coagulation time according to gender and blood groups A and O: in vitro study

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