Effects of Ethanol on Leptin Secretion and the Leptin‐Induced Luteinizing Hormone (LH) Release From Late Juvenile Female Rats

Hiney, Jill K.; Dearth, Robert K.; Lara, Francisco J.; Wood, Sarah G.; Srivastava, Vinod K.; Dees, W. Les

doi:10.1111/j.1530-0277.1999.tb04074.x

Cited by 26 publications

(7 citation statements)

References 62 publications

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“…Nevertheless, in our rats, serum leptin did not significantly correlate with serum LH. Hiney et al reported that leptin replacement was able to reverse the suppressed levels of LH caused by ethanol, but the onset of puberty was still delayed [24]. These results buttress our findings that LH is not the sole hormone which initiates puberty [25, 26].…”

Section: Discussionsupporting

confidence: 85%

Effect of Central Antileptin Antibody on the Onset of Female Rat Puberty

Chen¹,

Mick²,

Xu³

et al. 2009

International Journal of Pediatric Endocrinology

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The effect of intracerebroventricular (ICV) antileptin antibody on the onset of puberty in the female rat and the relationship between serum leptin, luteinizing hormone (LH), and body weight were investigated. Antileptin antibody (group A) was infused ICV from days 23-36 in prepubertal female rats whereas the control (group B) received ICV goat immunoglobulin G (IgG). In the antileptin group, mean day of vaginal opening (VO) was postponed (day 34 versus day 30, P < .01 ). Body weight trended higher after 30 days in the antileptin group but not significantly. However, there was no difference in serum leptin and LH between the two groups on the day of VO. Serum leptin was relatively constant from day 23 through day 31 and did not correlate with LH (r = 0.14, P = .10). These studies demonstrate that central leptin promotes the onset of female rat puberty as evidenced by VO. Finally, central leptin impacts female rat pubertal onset in distinction from serum leptin and body weight.

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Section: Discussionsupporting

confidence: 85%

Effect of Central Antileptin Antibody on the Onset of Female Rat Puberty

Chen¹,

Mick²,

Xu³

et al. 2009

International Journal of Pediatric Endocrinology

View full text Add to dashboard Cite

show abstract

“…Nevertheless, in our rats, serum leptin did not significantly correlate with serum LH. Hiney et al reported that leptin replacement was able to reverse the suppressed levels of LH caused by ethanol, but the onset of puberty was still delayed [ 24 ]. These results buttress our findings that LH is not the sole hormone which initiates puberty [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Central Antileptin Antibody on the Onset of Female Rat Puberty

Chen¹,

Mick

et al. 2009

International Journal of Pediatric Endocrinology

View full text Add to dashboard Cite

The effect of intracerebroventricular (ICV) antileptin antibody on the onset of puberty in the female rat and the relationship between serum leptin, luteinizing hormone (LH), and body weight were investigated. Antileptin antibody (group A) was infused ICV from days 23–36 in prepubertal female rats whereas the control (group B) received ICV goat immunoglobulin G (IgG). In the antileptin group, mean day of vaginal opening (VO) was postponed (day 34 versus day 30, P < .01 ). Body weight trended higher after 30 days in the antileptin group but not significantly. However, there was no difference in serum leptin and LH between the two groups on the day of VO. Serum leptin was relatively constant from day 23 through day 31 and did not correlate with LH (r = 0.14, P = .10). These studies demonstrate that central leptin promotes the onset of female rat puberty as evidenced by VO. Finally, central leptin impacts female rat pubertal onset in distinction from serum leptin and body weight.

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“…In female rats, chronic exposure to ethanol early in adolescence alters serum concentrations of hormones associated with puberty, such as luteinizing hormone, 95 and delays puberty. 96,97 In contrast, chronic exposure to alcohol beginning before and continuing through adolescence has been reported to increase aggressive behavior and testosterone levels in male hamsters 98 and to advance the onset of sexual behavior in male rats, 99 although delays in puberty-related increases in testosterone levels and sex organ size after adolescent alcohol exposure in male rats have also been reported. 100 …”

Section: Developmentally Related Effects Of Alcohol Use and Exposurementioning

confidence: 99%

Transitions Into Underage and Problem Drinking: Developmental Processes and Mechanisms Between 10 and 15 Years of Age

et al. 2008

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Numerous developmental changes occur across levels of personal organization (eg, changes related to puberty, brain and cognitive-affective structures and functions, and family and peer relationships) in the age period of 10 to 15 years. Furthermore, the onset and escalation of alcohol use commonly occur during this period. This article uses both animal and human studies to characterize these multilevel developmental changes. The timing of and variations in developmental changes are related to individual differences in alcohol use. It is proposed that this integrated developmental perspective serve as the foundation for subsequent efforts to prevent and to treat the causes, problems, and consequences of alcohol consumption. D URING THE DEVELOPMENTAL period spanning 10 to 15 years of age, considerable changes occur in biological, cognitive, emotional, and social processes, as well as physical and social contexts. These changes occur across different levels of personal organization, including overt physical appearance (eg, increases in physical size), refinements in the structure and function of the central nervous system (CNS), and maturational changes in the internal hormonal and neurophysiological milieus. By age 10, most adolescents have begun the rapid changes of puberty, as defined by changes in secretory patterns of the gonadal steroids. These hormonal changes are accompanied by dramatic changes in height as well as readily visible changes in body composition and secondary sexual characteristics, with overt physical differences between the genders becoming increasingly apparent.Whereas some personal changes are closely aligned with chronological age, such as attendance at elementary, middle, or high school, others are more closely tied to variations in the timing of events (pubertal onset) and/or developmental stages, such as interest in the opposite gender and relative peer influences. As a result, different aspects of personal development take place at different times, and different individuals mature in different dimensions at different times. For example, pubertal development may occur at a different time than does the socialcognitive development necessary for intimate relationships. The physical and emotional changes associated with pubertal development occur over a considerable age range. Adolescents who begin puberty relatively early may experience processes postulated to be associated with puberty, such as heightened emotional states and greater influences of external stimuli, sooner than they have the cognitive and emotional abilities to control consistently behaviors that develop as a function of the maturation of brain regions and collaborative brain networks.The average age of puberty has decreased over the past century, whereas the average age of assumption of adult roles has increased because of prolonged education by more youths and later age of initial marriage. These changes have heightened the significance of understanding adolescence along the multiple continua of physical, cogniti...

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Effects of Ethanol on Leptin Secretion and the Leptin‐Induced Luteinizing Hormone (LH) Release From Late Juvenile Female Rats

Cited by 26 publications

References 62 publications

Effect of Central Antileptin Antibody on the Onset of Female Rat Puberty

Effect of Central Antileptin Antibody on the Onset of Female Rat Puberty

Effect of Central Antileptin Antibody on the Onset of Female Rat Puberty

Transitions Into Underage and Problem Drinking: Developmental Processes and Mechanisms Between 10 and 15 Years of Age

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