Effects of ethanol on platelet thromboxane formation after ethanol withdrawal in chronic alcoholics: An in vitro study

Neiman, Jack

doi:10.1007/bf01852318

Cited by 9 publications

(2 citation statements)

References 37 publications

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“…In agreement with results of others (2,5,7,38,39), we found that platelet count increases upon withdrawal. Since ethanol suppresses thrombopoiesis (40), the increase in platelet count may be attributed to an alleviation of this suppression.…”

Section: Discussionsupporting

confidence: 93%

Effects of Alcohol Withdrawal on Responses of Platelets from Alcoholics - A Study Using Platelet-Rich Plasma from Blood Anticoagulated with D-Phenylalanyl-L-prolyl-L-arginyl Chloromethyl Ketone (FPRCH2CI)

et al. 1990

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SummaryPlatelet responses stimulated by a range of concentrations of ADP or collagen were studied in platelet-rich plasma (PRP) from alcoholics 24-36 h and 6 days after cessation of drinking, and in PRP from age- and sex-matched controls. The studies were done using plasma from blood anticoagulated with the specific thrombin inhibitor D-pheny1a1any1-T,-prolyl-L-arginyl chloromethyl ketone (FPRCH2Cl, PPACK); the use of this compound permits the study of platelet responses in plasma at physiological concentrations of ionized calcium. Responses of platelets to ADP (primary aggregation) and collagen (aggregation, secretion of [14C]serotonin from prelabelled platelets, and thromboxane formation) were lower in alcoholics 24-36 h after withdrawal of alcohol compared with controls. This inhibition of platelet function was not due to the presence of alcohol in the blood of the alcoholics. Aggregation in response to ADP did not change during the withdrawal period studied, while collagen-induced aggregation and secretion increased significantly and collagen-induced thromboxane formation tended to increase towards control values. The reduced platelet responses observed in alcoholics and the different rates of “recovery” of different pathways of aggregation towards control values must be due to alterations either in the platelets themselves and/or in the plasma brought about by the chronic presence of ethanol, and its withdrawal.

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Section: Discussionsupporting

confidence: 93%

Effects of Alcohol Withdrawal on Responses of Platelets from Alcoholics - A Study Using Platelet-Rich Plasma from Blood Anticoagulated with D-Phenylalanyl-L-prolyl-L-arginyl Chloromethyl Ketone (FPRCH2CI)

et al. 1990

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“…Plasma tissue plasminogen activator (tPA) antigen was reported also to be increased in heavy drinkers, which is consistent with a decreased fibrinolytic activity 65 . The acute withdrawal of ethanol is known to have rebound effects, including the activation of platelets by normal agonists 66 ; therefore, while moderate alcohol consumption can be protective against cardiovascular disease partly through decreased fibrinogen levels, short-term binge drinking may have a hypofibrinolytic effect through increased PAI-1 levels and rebound platelet hyperaggregability 67 .…”

Section: Discussionmentioning

confidence: 99%

Acute and chronic blood serum proteome changes in patients with methanol poisoning

Cejnar

Smirnova

Kučková

et al. 2022

Sci Rep

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Twenty-four blood serum samples from patients with acute methanol poisoning (M) from the mass methanol poisoning outbreak in the Czech Republic in 2012 were compared with 46 patient samples taken four years after poisoning (S) (overlap of 10 people with group M) and with a control group (C) of 24 samples of patients with a similar proportion of chronic alcohol abuse. When comparing any two groups, tens to hundreds of proteins with a significant change in concentration were identified. Fifteen proteins showed significant changes when compared between any two groups. The group with acute methanol poisoning showed significant changes in protein concentrations for at least 64 proteins compared to the other groups. Among the most important identified proteins closely related to intoxication are mainly those involved in blood coagulation, metabolism of vitamin A (increased retinol-binding protein), immune response (e.g., increased complement factor I, complement factors C3 and C5), and lipid transport (increased apolipoprotein A I, apolipoprotein A II, adiponectin). For blood coagulation, the most affected proteins with significant changes in the methanol poisoning group were von Willebrand factor, carboxypeptidase N, alpha-2-antiplasmin (all increased), inter-alpha-trypsin inhibitor heavy chain H4, kininogen-1, plasma serine protease inhibitor, plasminogen (all decreased). However, heparin administration used for the methanol poisoning group could have interfered with some of the changes in their concentrations. Data are available via ProteomeXchange with the identifier PXD035726.

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2005

Cardiovascular Disease

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Effects of ethanol on platelet thromboxane formation after ethanol withdrawal in chronic alcoholics: An in vitro study

Cited by 9 publications

References 37 publications

Effects of Alcohol Withdrawal on Responses of Platelets from Alcoholics - A Study Using Platelet-Rich Plasma from Blood Anticoagulated with D-Phenylalanyl-L-prolyl-L-arginyl Chloromethyl Ketone (FPRCH2CI)

Effects of Alcohol Withdrawal on Responses of Platelets from Alcoholics - A Study Using Platelet-Rich Plasma from Blood Anticoagulated with D-Phenylalanyl-L-prolyl-L-arginyl Chloromethyl Ketone (FPRCH2CI)

Acute and chronic blood serum proteome changes in patients with methanol poisoning

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