Effects of Ethanol on the Functional Properties of Sodium Channels in Brain Synaptosomes

Mullin, Michael; Hunt, Walter A.

doi:10.1007/978-1-4899-1684-6_11

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…Ethanol reduces essential tremor amplitude in up to 67% of patients, whereas the efficacy of diazepam is far lower (39). This finding implies that alcohol is not acting solely via central benzodiazepine receptor agonistic action but may also have other effects-for example, suppressing sodium ion channel activity (40) or transiently decreasing nerve membrane conductance (41). Using H 2 15 O PET, we showed that ethanol reduces the abnormally elevated cerebellar regional cerebral blood flow in essential tremor patients, thereby reducing the inhibitory input in the deep cerebellar nuclei.…”

Section: Discussionmentioning

confidence: 70%

GABAergic Dysfunction in Essential Tremor: An¹¹C-Flumazenil PET Study

Boecker¹,

Weindl²,

Brooks³

et al. 2010

J Nucl Med

123

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Section: Discussionmentioning

confidence: 70%

GABAergic Dysfunction in Essential Tremor: An¹¹C-Flumazenil PET Study

Boecker¹,

Weindl²,

Brooks³

et al. 2010

J Nucl Med

123

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“…Thus the increased transmitter release caused by Bay K8644 is enhanced in ethanol-dependent rats. However, ethanol has a variety of effects on other ion channels (Mullin & Hunt, 1987) so there is still debate as to whether Ca2+ channels remain the primary target. As changes in membrane fluidity will underly many of the effects, it is to be expected that ethanol will have multiple effects on neuronal function; dosage will be critical.…”

Section: Channel Plasticitymentioning

confidence: 99%

Activators and Inactivators of Calcium Channels: Effects in the Central Nervous System

Spedding¹,

Kilpatrick²,

Alps³

1989

Fundamemntal Clinical Pharma

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The interactions of calcium antagonists or channel activators with the different classes of calcium channel are reviewed with particular emphasis on interactions with neuronal tissue; reasons for the failure of calcium antagonists to inhibit neurotransmitter release under normal circumstances are outlined. Calcium antagonists may be protective in several pathological situations and the possibilities of protection against ischaemic damage in the central nervous system are evaluated.

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“…Interestingly, SCLT1 produces a linker-like protein between the voltage-gated sodium channel Na(v)1.8 (SCN10A) and clathrin (CLTC), a ubiquitous protein involved in receptor endocytosis and recycling (Liu et al 2005). Sodium channel activity, particularly Na(v)1.8, has been associated with the neuronal effects of ethanol exposure (Mullin & Hunt 1987; Harris & Allan 1989; Horishita & Harris 2008) and linked to alcohol use behavior (Botta et al . 2010).…”

Section: Discussionmentioning

confidence: 99%

Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma‐exposed populations

et al. 2017

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Excessive alcohol use is extremely prevalent in the United States, particularly among trauma-exposed individuals. While several studies have examined genetic influences on alcohol use and related problems, this has not been studied in the context of trauma-exposed populations. We report results from a genome-wide association study of alcohol consumption and associated problems as measured by the alcohol use disorders identification test (AUDIT) in a traumaexposed cohort. Results indicate a genome-wide significant association between total AUDIT score and rs1433375 [N = 1036, P = 2.61 × 10 À8 (dominant model), P = 7.76 × 10 À8 (additive model)], an intergenic single-nucleotide polymorphism located 323 kb upstream of the sodium channel and clathrin linker 1 (SCLT1) at 4q28. rs1433375 was also significant in a meta-analysis of two similar, but independent, cohorts (N = 1394, P = 0.0004), the Marine Resiliency Study and Systems Biology PTSD Biomarkers Consortium. Functional analysis indicated that rs1433375 was associated with SCLT1 gene expression and cortical-cerebellar functional connectivity measured via resting state functional magnetic resonance imaging. Together, findings suggest a role for sodium channel regulation and cerebellar functioning in alcohol use behavior. Identifying mechanisms underlying risk for problematic alcohol use in traumaexposed populations is critical for future treatment and prevention efforts.

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Effects of Ethanol on the Functional Properties of Sodium Channels in Brain Synaptosomes

Cited by 6 publications

References 18 publications

GABAergic Dysfunction in Essential Tremor: An¹¹C-Flumazenil PET Study

GABAergic Dysfunction in Essential Tremor: An¹¹C-Flumazenil PET Study

Activators and Inactivators of Calcium Channels: Effects in the Central Nervous System

Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma‐exposed populations

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Effects of Ethanol on the Functional Properties of Sodium Channels in Brain Synaptosomes

Cited by 6 publications

References 18 publications

GABAergic Dysfunction in Essential Tremor: An11C-Flumazenil PET Study

GABAergic Dysfunction in Essential Tremor: An11C-Flumazenil PET Study

Activators and Inactivators of Calcium Channels: Effects in the Central Nervous System

Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma‐exposed populations

Contact Info

Product

Resources

About

GABAergic Dysfunction in Essential Tremor: An¹¹C-Flumazenil PET Study

GABAergic Dysfunction in Essential Tremor: An¹¹C-Flumazenil PET Study