Effects of Ethanolic Extract of Cynara cardunculus (Artichoke) Leaves on Neuroinflammatory and Neurochemical Parameters in a Diet-Induced Mice Obesity Model

Piccinini, Alexandre; Oliveira, Mariana Pacheco de; Silva, Mariella Reinol; Bett, Gabriela Souza; Becker, Isabel Borges; Mendes, Talita Farias; Salla, Daniéle Hendler; Silva, Larissa Espindola; Vilela, Thais Ceresér; Moraes, Fernanda Mendes de; Moterle, Diego; Damiani, Adriani Paganini; Dagostin, Ligia Salvan; Tietbohl, Lariani Tamires Witt; Bittencourt, João Vitor Silvano; Biehl, Erica; Denicol, Taís; Bonfante, Sandra; Andrade, Vanessa Moraes de; Prophiro, Josiane Somariva; Ferreira, Gabriela K.; Petronilho, Fabrícia; Κanis, Luiz Alberto; Rezin, Gislaine T.

doi:10.1007/s11064-022-03572-6

Cited by 4 publications

(7 citation statements)

References 71 publications

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“…In accordance with these findings, it was recently found in a mouse model of induced obesity that the ethanolic extract of artichoke extracts has beneficial effects on neuroinflammatory parameters [ 117 ].…”

Section: Neuroprotective Effects Of Artichokesupporting

confidence: 66%

“…It is well-documented that obesity can cause neuroinflammation and increased oxidative stress in the brain [ 118 ]. In the same context, Piccinini et al explored the effect of artichoke leaf ethanol extract on inflammatory and oxidative stress in different brain areas, including the hypothalamus, prefrontal cortex, hippocampus, striatum, and the cerebral cortex, in mice fed with high-fat diet [ 117 ].…”

Section: Neuroprotective Effects Of Artichokementioning

confidence: 99%

“…Isochlorogenic acid B (ICAB), also known as 3,4-dicaffeoylquinic acid, is a dietary flavonoid present in various plants including artichoke. It possesses multiple pharmacological effects, such as antioxidative, anti-inflammatory, and hepatoprotective effects [ 117 , 123 , 124 , 125 ].…”

Section: Neuroprotective Effects Of Artichokementioning

confidence: 99%

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Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

Porro,

Benameur,

Cianciulli

et al. 2024

Nutrients

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Dietary supplements enriched with bioactive compounds represent a promising approach to influence physiological processes and enhance longevity and overall health. Cynara cardunculus var. scolymus serves as a functional food supplement with a high concentration of bioactive compounds, which offers various health-promoting benefits. Several chronic diseases have metabolic, genetic, or inflammatory origins, which are frequently interconnected. Pharmacological treatments, although effective, often result in undesirable side effects. In this context, preventive approaches are gaining increased attention. Recent literature indicates that the consumption of bioactive compounds in the diet can positively influence the organism’s biological functions. Polyphenols, well-known for their health benefits, are widely recognized as valuable compounds in preventing/combating various pathologies related to lifestyle, metabolism, and aging. The C. scolymus belonging to the Asteraceae family, is widely used in the food and herbal medicine fields for its beneficial properties. Although the inflorescences (capitula) of the artichoke are used for food and culinary purposes, preparations based on artichoke leaves can be used as an active ingredient in herbal medicines. Cynara scolymus shows potential benefits in different domains. Its nutritional value and health benefits make it a promising candidate for improving overall well-being. C. scolymus exhibits anti-inflammatory, antioxidant, liver-protective, bile-expelling, antimicrobial, and lipid-lowering neuroprotective properties. Different studies demonstrate that oxidative stress is the leading cause of the onset and progression of major human health disorders such as cardiovascular, neurological, metabolic, and cancer diseases. The large amount of polyphenol found in C. scolymus has an antioxidant activity, enabling it to neutralize free radicals, preventing cellular damage. This reduces the subsequent risk of developing conditions such as cancer, diabetes, and cardiovascular diseases. Additionally, these polyphenols demonstrate anti-inflammatory activity, which is closely associated with their antioxidant properties. As a result, C. scolymus has the potential to contribute to the treatment of chronic diseases, including intestinal disorders, cardiovascular diseases, and neurodegenerative pathologies. The current review discussed the nutritional profiles, potential benefits, and pharmacological effects of C. scolymus.

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Section: Neuroprotective Effects Of Artichokesupporting

confidence: 66%

Section: Neuroprotective Effects Of Artichokementioning

confidence: 99%

See 1 more Smart Citation

Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

Porro,

Benameur,

Cianciulli

et al. 2024

Nutrients

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“…Data also suggests that artichoke may have anti-obesity potential in rodents and humans [ 49 , 66 , 73 , 75 , 77 ]. This potential has been noted for artichoke leaf ethanol extract (160 mg/kg/day, for four weeks) in mice with diet-induced obesity [ 73 ], while artichoke consumption has been shown to have various effects, including inhibiting the action of digestive enzymes (lipase, α-glucosidase, and α-amylase), exerting a prebiotic effect, and enhancing lipolysis and lipid metabolism [ 107 ]. Inhibition of the secretion of inflammatory adipokines is also associated with the anti-obesity effect [ 108 ].…”

Section: Biological Activity Of Different Parts Of C Scolymusmentioning

confidence: 99%

An Overview of the Versatility of the Parts of the Globe Artichoke (Cynara scolymus L.), Its By-Products and Dietary Supplements

Olas

2024

Nutrients

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Cynara scolymus, also known as the globe artichoke or artichoke, is grown as a food, mainly in the Mediterranean, Canary Islands, and Egypt, as well as in Asia and South America. It has also been associated with various health benefits and is used in plant-based dietary supplements and herbal infusions. Its edible parts, consisting of the head or capitula, flower, and leaves, have shown various biological activities, including anti-cancer, hepatoprotective and antimicrobial potential. The leaves are mainly used in infusions and extracts for their health-promoting properties, although all their edible parts may also be consumed as fresh, frozen, or canned foods. However, its primary health-promoting activity is associated with its antioxidant potential, which has been linked to its chemical composition, particularly its phenolic compounds (representing 96 mg of gallic acid equivalent per 100 g of raw plant material) and dietary fiber. The main phenolic compounds in the heads and leaves are caffeic acid derivatives, while the flavonoids luteolin and apigenin (both present as glucosides and rutinosides) have also been identified. In addition, heat-treated artichokes (i.e., boiled, steamed or fried), their extracts, and waste from artichoke processing also have antioxidant activity. The present paper reviews the current literature concerning the biological properties of different parts of C. scolymus, its by-products and dietary supplements, as well as their chemical content and toxicity. The literature was obtained by a search of PubMed/Medline, Google Scholar, Web of Knowledge, ScienceDirect, and Scopus, with extra papers being identified by manually reviewing the references.

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“…In particular, the artichoke (Cynara cardunculus) has several beneficial properties for health. Some research has highlighted both anti-inflammatory, antioxidant and anti-bacterial effects, as well as the inhibition of cholesterol biosynthesis, oxidation of low-density lipoproteins [111]. These effects have been attributed to the presence of polyphenolic compounds contained in the artichoke.…”

Section: Anti-inflammatory Effects In the Brain And Protective Effect...mentioning

confidence: 99%

Insights into the Biological Roles of Artichoke Extracts: Implications in Intestinal, Cardiovascular, and Neurodegenerative Diseases

Porro,

Benameur,

Cianciulli

et al. 2023

Preprint

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Several chronic diseases derive from metabolic, genetic, or inflammatory causes and often these causes are interconnected. Pharmacological treatments, although effective, often lead to unpleasant side effects. In this context, preventive approaches are of growing interest. The literature data of recent years support that the dietary intake of bioactive compounds can positively influence the biological functions of an organism. Among the bioactive compounds in the diet, polyphenols are widely recognized for their beneficial effects on health, as useful compounds for preventing/combating a series of pathologies related to lifestyle, metabolism, and aging. The artichoke (Cynara scolymus L.), a member of the Asteraceae family, is widely used in the food and herbal medicine fields for its beneficial properties. Artichokes are rich in polyphenols (including cynarin), flavonoids and their derivatives, and, for this reason, they have aroused interest in their pharmacological properties. The best-known activity of polyphenols is antioxidant activity. Through it, they help to neutralize free radicals, preventing cellular damage and the subsequent risk of conditions such as cancer, diabetes, and heart disease. Related to the antioxidant action we find the anti-inflammatory activity. This is an important benefit since chronic inflammation is a cause or contributory cause of many chronic diseases. Although many scientific results are of great interest and potential, there are still gaps to be filled. In this review, we report and discuss new insights providing documented evidence regarding the benefits of the artichoke compounds and their possible use to support the pharmacological treatment of pathologies associated with inflammation.

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Effects of Ethanolic Extract of Cynara cardunculus (Artichoke) Leaves on Neuroinflammatory and Neurochemical Parameters in a Diet-Induced Mice Obesity Model

Cited by 4 publications

References 71 publications

Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

An Overview of the Versatility of the Parts of the Globe Artichoke (Cynara scolymus L.), Its By-Products and Dietary Supplements

Insights into the Biological Roles of Artichoke Extracts: Implications in Intestinal, Cardiovascular, and Neurodegenerative Diseases

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