Effects of excitotoxic lesions of the gustatory thalamus on latent inhibition and blocking of conditioned taste aversion in rats

Reilly, Steve; Bornovalova, Marina A.; Dengler, Christine; Trifunovic, Radmila

doi:10.1016/j.brainresbull.2003.08.009

Cited by 17 publications

(20 citation statements)

References 48 publications

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“…However, more recent research, using electrolytic lesions that caused minimal damage beyond the boundaries of the GT, finds no evidence that discrete GT lesions disrupt first-order CTA (e.g., Flynn, Grill, Schulkin, & Norgren, 1991;Grigson, Lyuboslavsky, & Tanase, 2000;Reilly & Pritchard, 1996). Although ibotenic acid GT lesions do disrupt CTA acquisition when multiple CSs are involved (Reilly, Bornovalova, Dengler, & Trifunovic, 2003), the deficit cannot be interpreted as a disruption in the processing of US-related information.…”

Section: Discussionmentioning

confidence: 98%

C-fos expression in the rat brain following lithium chloride-induced illness

2007

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The present study examined c-Fos expression in selected brain areas consequent to administration of lithium chloride, the typical illness-inducing agent used in laboratory studies of conditioned taste aversion. The results replicated previous findings of significant c-Fos expression in the parabrachial nucleus, the central nucleus of the amygdala and the basolateral amygdala. New findings indicate significant lithium-induced c-Fos in the gustatory region of the thalamus and the bed nucleus of the stria terminalis but not in the insular cortex. The results are discussed with respect to the neural substrates of conditioned taste aversion.

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Section: Discussionmentioning

confidence: 98%

C-fos expression in the rat brain following lithium chloride-induced illness

2007

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“…This level of deprivation was used to maintain comparability with our previous study of the influence of IC lesions on CTA and conditioned odour aversion (Roman et al, 2006) and our work on latent inhibition in CTA (Reilly et al, 2003;St Andre & Reilly, 2007). Once water intake stabilized, the rats were divided into groups based on lesion (SHAM or ICX) and whether they would be pre-exposed (Familiar condition) or not (Novel condition) to the CS before conditioning: SHAM-Familiar (n = 10), SHAM-Novel (n = 10), ICX-Familiar (n = 11), and ICXNovel (n = 11).…”

Section: Methodsmentioning

confidence: 99%

“…Reilly et al, 2003;St Andre & Reilly, 2007). Furthermore, with the exception of Kiefer & Braun (1977), all of the studies that have examined CTA acquisition in pre-exposed insular cortex-lesioned (ICX) rats failed to include a group of nonpre-exposed control rats (e.g.…”

Section: Introductionmentioning

confidence: 99%

Effects of insular cortex lesions on conditioned taste aversion and latent inhibition in the rat

Roman

Reilly

2007

Eur J of Neuroscience

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The present study tested the hypothesis that lesions of the insular cortex of the rat retard the acquisition of conditioned taste aversions (CTAs) because of an impairment in the detection of the novelty of taste stimuli. Demonstrating the expected latent inhibition effect, nonlesioned control subjects acquired CTAs more rapidly when the conditioned stimulus (0.15% sodium saccharin) was novel rather than familiar (achieved by pre-exposure to the to-be-conditioned taste cue). However, rats with insular cortex lesions acquired taste aversions at the same slow rate regardless of whether the saccharin was novel or familiar. The pattern of behavioural deficits obtained cannot be interpreted as disruptions of taste detection or stimulus intensity, but is consistent with the view that insular cortex lesions disrupt taste neophobia, a dysfunction that consequently retards CTA acquisition because of a latent inhibition-like effect.

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“…Some studies have reported that VPMpc-lesioned animals retain a normal concentration response to preferred and non-preferred tastes [134][135][136][137] but may have disrupted [137], impaired [127,130] or else have no effects on CTA [134,135,138,139]. Current views suggest a role in comparing novel and familiar tastes [140] in more complex gustatory learning tasks or in attention to gustatory function [135,136,141].…”

Section: The Gustatory System In the Ratmentioning

confidence: 99%