Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice

Vieira, Victoria J.; Valentine, Rudy J.; Wilund, Kenneth R.; Antao, Nirav; Baynard, Tracy; Woods, Jeffrey A.

doi:10.1152/ajpendo.00054.2009

Cited by 169 publications

(181 citation statements)

References 37 publications

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“…35 Adipose tissue inflammation might also explain links between sedentary behaviour and inflammation. 36 Indeed, reductions in central adiposity largely explain the changes in CRP observed after aerobic exercise training interventions. 37,38 Thus, excess TV viewing may simply be a marker of chronic energy imbalance indicated by excess adiposity.…”

Section: Discussionmentioning

confidence: 99%

Prospective association of TV viewing with acute phase reactants and coagulation markers: English Longitudinal Study of Ageing

2015

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Section: Discussionmentioning

confidence: 99%

Prospective association of TV viewing with acute phase reactants and coagulation markers: English Longitudinal Study of Ageing

2015

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“…Further, it was suggested that exercise intervention was more effective than low fat diet treatment for reducing hepatic steatosis, but both exercise and a low fat diet were effective in improving the anti-inflammatory response and metabolic outcomes [26,27].…”

Section: Introduction *mentioning

confidence: 99%

Moderate exercise training is more effective than resveratrol supplementation for ameliorating lipid metabolic complication in skeletal muscle of high fat diet-induced obese mice

Jeong

Park

Lee

et al. 2015

J. Exerc. Nutr, Biochem.

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. Moderate exercise training is more effective than resveratrol supplementation for ameliorating lipid metabolic complication in skeletal muscle of high fat diet-induced obese mice. JENB., Vol. 19, No. 2, pp.131-137, 2015 [Purpose] The aim of this study was to compare the effectiveness of moderate exercise training or resveratrol supplementation with a low fat diet on lipid metabolism in the skeletal muscle of high fat diet-induced obese mice.[Methods] C57BL/6J mice (5 weeks old, n = 30) were fed a high fat diet (45% fat) for 8 weeks first to make them obese. Afterward, all the mice were fed a low fat diet during 8 weeks of intervention with moderate exercise training and resveratrol supplementation. Before the intervention, the mice were separated into 3 groups: low-fat diet control (HLC; n = 10), low fat diet with resveratrol (HLR; n = 10) or low fat diet with exercise (HLE n = 10). The exercise group (HLE) performed treadmill running for 30-60 min/day at 10-22 m/min, 0% grade, 5 times/week for 8 weeks, while the resveratrol group (HLR) received a daily dose of resveratrol (10 mg/kg of body weight), 5 days/week for 8 weeks.[Results] Body weight was significantly reduced in HLE. Further, the lipogenesis marker SREBP and the inflammatory cytokine TNF-α were significant reduced in HLE. However, there was no significant effect from resveratrol supplementation with a low fat diet. Taken together, exercise training with a low fat diet has the positive effect of ameliorating lipid disturbance in the skeletal muscle of high fat diet-induced obese mice.[Conclusion] These findings suggest that exercise training with a low fat diet is most effective to improve lipid metabolism by reducing lipogenesis and inflammation in the skeletal muscle of high fat diet-induced obese mice.

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“…This leads to the stimulation of angiogenesis in adipose tissue and generally results in excessive adipose tissue growth and development with obesity being the eventual outcome. We have shown previously that both exercise and low fat diet reduce leptin gene expression in adipose tissue (52). This is relevant as leptin is also a target gene for HIF-1 (50).…”

Section: Future Directionsmentioning

confidence: 83%

“…Tissues were harvested immediately after sacrifice, weighed, flash frozen and stored for later analysis. This paradigm, with the exception of the added control group, is similar to the model used in a recently published study by our lab and summarized in figure 2 (52). …”

Section: Methodsmentioning

confidence: 99%

“…Recent work from our lab showed that both exercise, low fat diet, and their combination result in significant reductions of obesity-induced increases in inflammation, both systemically and locally in the white adipose tissue (52). One potential mechanism by which exercise may be reducing inflammation in the adipose tissue, which has not been examined and is investigated here, is by changes in adipose tissue hypoxia.…”

Section: Chapter 1: Introductionmentioning

confidence: 92%

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Reduced adipose tissue hypoxia as a potential mechanism by which exercise and/or low fat diet reduces inflammation in obese mice

Cady

Woods

Baynard

et al. 2010

Brain, Behavior, and Immunity

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Recent evidence from our lab suggests that, in high fat diet-induced (HFD, 45% fat) obese mice, moderate exercise, low fat diet (LFD, 10% fat), or their combination results in significant reductions in the visceral adipose tissue inflammation. Adipose tissue hypoxia, perhaps involving cell stress or death, has been suggested as one of the major initiating events inciting inflammation. Purpose-The purpose of the proposed study was to investigate adipose tissue hypoxia as a potential mechanism by which exercise and/or low fat diet might exert antiinflammatory effects in adipose tissue. Methods-Male C57BL/6 mice (n=73) fed a 45% high fat diet for 6 weeks to induce obesity were randomly assigned to one of 4 groups: exercised (5 days/week, 40 min/day, 65-70% VO 2 max) high fat diet or low fat diet or sedentary high fat diet or low fat diet for 12 weeks in a 2 x 2 design. In a subset of these mice (n=32), adipose tissue hypoxia was measured in epididymal fat pads using pimonidazole hydrochloride (injected intraperitonealy at a concentration of 60 mg/g body weight) and detected via ELISA. ResultsExercise and diet interventions had similar effects at attenuating body weight and epididymal fat pad weight gain as compared to a recent study from our lab where mice underwent the same interventions. There was a significant (F 1,23 =6.3; p=0.02) exercise x diet interaction such that adipose tissue hypoxia in the combined intervention was significantly less than all other groups with a tendency for low fat diet alone to be more efficacious than exercise alone. ConclusionThese circumstantial data suggest that adipose tissue hypoxia may be a potential mechanism by which both regular exercise and/or a low fat diet reduce adipose tissue inflammation and that exercise when combined with low fat diet provides a strong enough stimulus to reduce adipose tissue hypoxia.iii ACKNOWLEDGEMENTS

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Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice

Cited by 169 publications

References 37 publications

Prospective association of TV viewing with acute phase reactants and coagulation markers: English Longitudinal Study of Ageing

Prospective association of TV viewing with acute phase reactants and coagulation markers: English Longitudinal Study of Ageing

Moderate exercise training is more effective than resveratrol supplementation for ameliorating lipid metabolic complication in skeletal muscle of high fat diet-induced obese mice

Reduced adipose tissue hypoxia as a potential mechanism by which exercise and/or low fat diet reduces inflammation in obese mice

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