Effects of exercise and training on plasma lipids and lipoproteins in the rat

Nm, Papadopoulos; Cm, Bloor; Jc, Standefer

doi:10.1152/jappl.1969.26.6.760

Cited by 38 publications

(11 citation statements)

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“…Whereas a number of investigators have found exercise to lead to reduced body weight gain (7)(8)(9), no difference was evident in the body weights of exercising and nonexercising rats in the present experiment. The lack of such a difference in the present study can perhaps be accounted for by the effects of the stress conditions.…”

Section: Discussioncontrasting

confidence: 93%

“…Consistent with other studies on the effects of exercise using rats (7)(8)(9), running led to reduced levels of plasma cholesterol. Although the running rats in the present study did not differ from their nonrunning counterparts in body weight, food intake, or number of shocks received, they were lower in concentrations of plasma cholesterol, In fact, a significant negative correlation was evident between the total number of revolutions run and plasma cholesterol levels for the entire running group, r = -0.40, p < 0.05.…”

Section: Discussionsupporting

confidence: 91%

“…Physical activity, on the other hand, has been found to result in decreased levels of blood cholesterol in rats (7)(8)(9). Applegate et al (9) exercised rats on a treadmill for 22 daily sessions.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Stress and Exercise on Plasma Corticosterone, Plasma Cholesterol, and Aortic Cholesterol Levels in Rats

Starzec

Berger

Hesse

1983

Psychosomatic Medicine

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Rats, fed a 1% cholesterol diet, were subjected to either predictable, controllable shock; unpredictable, uncontrollable shock; or no shock for 30 days (51-min daily sessions). Half of the rats in each condition were allowed access to a running wheel for 3 hr immediately after each stress session except for the final stress session. Immediately following the final stress session, animals were sacrificed and blood and aorta samples were taken. Stressed animals allowed to run showed lower plasma corticosterone levels than stressed animals not allowed to run. Overall, stressed animals had lower levels of aortic cholesterol than nonstressed animals. Whereas running resulted in decreased levels of plasma cholesterol, aortic cholesterol levels were higher for the running animals than for the nonrunning animals.

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Section: Discussioncontrasting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

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Effects of Stress and Exercise on Plasma Corticosterone, Plasma Cholesterol, and Aortic Cholesterol Levels in Rats

Starzec

Berger

Hesse

1983

Psychosomatic Medicine

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“…However, physically active men above this age did not have a significantly lower plasma cholesterol concentration than inactive controls. In the rat, Papadopoulos et al 3 observed that plasma cholesterol decreased in response to exercise; however, others found no such effect. 4 …”

mentioning

confidence: 98%

Age-related changes in the concentration of plasma cholesterol and triglycerides in two groups of rats with inherited widely different levels of spontaneous physical activity.

Rasmussen¹,

Hłstmark²

1978

Circulation Research

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SUMMARY The plasma concentration of cholesterol and triglycerides was determined in two groups of rats with inherited widely different levels of spontaneous physical activity. Active as well as passive rats of each sex were divided into two subgroups, one with free access to wheel running activity {exercising group), and another for which admittance to the drum was closed (nonexercising group). Plasma concentrations of cholesterol and triglycerides were followed from the age of 3-8 months in females and 3 months to 1 year in males. A pronounced increase with age in the plasma concentration of these lipids was observed in the active male rats. In the passive male rats and in all females, there were no major changes in plasma levels of cholesterol and triglycerides. Corresponding groups of exercising and nonexercising rats had similar plasma levels of these components. The data for male rats show a positive association between the inherited tendency to perform spontaneously a high level of physical activity and an age-related increase in plasma lipids. However, running activity per se does not seem to have any influence on the level of plasma cholesterol and triglycerides in these rats.REPORTS ON the chronic effects of physical activity on plasma lipid concentration are conflicting. In man, Lopez-S et al.1 observed a minimal decrease in plasma cholesterol level following long-term physical training. Also Wood et al.2 reported a somewhat lower plasma cholesterol concentration in physically active men, 35-39 years of age, compared to that found in a control group of relatively inactive men. However, physically active men above this age did not have a significantly lower plasma cholesterol concentration than inactive controls. In the rat, Papadopoulos et al. 3 observed that plasma cholesterol decreased in response to exercise; however, others found no such effect. "7 Even an increased concentration of cholesterol in response to long-term exercise was observed by Herbert et al. 8 in old rats maintained on a high sucrose diet. A lowering effect of long-term physical activity on plasma triglyceride concentration appears to be a more consistent finding. It has been demonstrated in this laboratory, through selective breeding, that the level of spontaneous physical activity in rats is inheritable. In offspring of active parents, the level of spontaneous wheel-running activity is severalfold higher than that observed in offspring of passive parents. In an attempt to elucidate the effect of voluntary physical activity on the level of plasma lipids, we have determined the concentration of cholesterol and triglycer- Received July 7, 1977; accepted for publication December 13, 1977. ides in the plasma of two groups of selected female and male rats with widely differing levels of spontaneous wheel-running activity. The plasma lipid concentration was followed from the age of 3-8 months in females and from 3 months to 1 year in males, i.e., for about one-third to one-half of their normal life-span. The rats were kept individu...

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“…Papadopoulos aj^. (92) were able to lower rat serum triglycerides and cholesterol with only four weeks of swimming. Hanson e^ al.…”

Section: Exercisementioning

confidence: 97%

Effect of diet and exercise on atherosclerosis in the goat

Kenealy

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Effects of exercise and training on plasma lipids and lipoproteins in the rat

Cited by 38 publications

References 0 publications

Effects of Stress and Exercise on Plasma Corticosterone, Plasma Cholesterol, and Aortic Cholesterol Levels in Rats

Effects of Stress and Exercise on Plasma Corticosterone, Plasma Cholesterol, and Aortic Cholesterol Levels in Rats

Age-related changes in the concentration of plasma cholesterol and triglycerides in two groups of rats with inherited widely different levels of spontaneous physical activity.

Effect of diet and exercise on atherosclerosis in the goat

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