2023
DOI: 10.1038/s41526-023-00256-5
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Effects of exercise countermeasures on multisystem function in long duration spaceflight astronauts

Abstract: Exercise training is a key countermeasure used to offset spaceflight-induced multisystem deconditioning. Here, we evaluated the effects of exercise countermeasures on multisystem function in a large cohort (N = 46) of astronauts on long-duration spaceflight missions. We found that during 178 ± 48 d of spaceflight, ~600 min/wk of aerobic and resistance exercise did not fully protect against multisystem deconditioning. However, substantial inter-individual heterogeneity in multisystem response was apparent with … Show more

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Cited by 31 publications
(18 citation statements)
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“…aerobic or resistance training) and of its dose (i.e. intensity, duration and frequency) are still debated [45]. Papers about high intensity interval training (HIIT) seem to indicate that the metabolic power of the bouts, to elicit an improvement in cardio-circulatory fitness, should be higher than 90% of true0 V ˙ O 2 normalm normala normalx [46].…”
Section: Discussionmentioning
confidence: 99%
“…aerobic or resistance training) and of its dose (i.e. intensity, duration and frequency) are still debated [45]. Papers about high intensity interval training (HIIT) seem to indicate that the metabolic power of the bouts, to elicit an improvement in cardio-circulatory fitness, should be higher than 90% of true0 V ˙ O 2 normalm normala normalx [46].…”
Section: Discussionmentioning
confidence: 99%
“…In an increasing aging population, progressive muscle atrophy or sarcopenia leads to a dramatic decline in mobility 2 , and yet remains without effective therapeutic options 3,4 . Astronauts, on the other hand, experience signi cant muscle loss in an accelerated timescale, 20% over two weeks, compared to 1-2% per year for the typical person over age 35 5,6 , such that complete prevention is not attainable with rigorous exercise 7 . In collaboration with AdventHealth, Translational Research Institute (TRI), we obtained percutaneous biopsies of the vastus lateralis from ve young, athletic (<40 yrs, YA) and ve older, sedentary (>60 yrs, OS) volunteers, and derived muscle precursor cells that were then puri ed for CD56 + selection, a cell surface marker expressed in myogenic cells (Fig 1A).…”
Section: Introductionmentioning
confidence: 99%
“…Microgravity poses a unique challenge to astronaut health, particularly affecting the musculoskeletal system. Muscle atrophy and bone density reduction are among the most pressing health issues faced during extended missions, necessitating innovative solutions to mitigate these effects [10][11][12][13][14][15][16][17][18][19] .…”
Section: Introductionmentioning
confidence: 99%
“…Nevertheless, the full mechanism and impact of microgravity on the human body, especially in real space conditions, are still not entirely understood 12 . Astronauts aboard the International Space Station (ISS) undergo rigorous exercise regimens to combat the adverse effects of living in space [10][11][12][17][18][19]28 . While these exercises help, they don't completely negate the physiological changes induced by microgravity 12,19 .…”
Section: Introductionmentioning
confidence: 99%
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