Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial

Kleckner, Ian R.; Kamen, Charles; Gewandter, Jennifer S.; Mohile, Nimish; Heckler, Charles E.; Culakova, Eva; Fung, Chunkit; Janelsins, Michelle Christine; Asare, Matthew; Lin, Po‐Ju; Reddy, Pavan S.; Giguere, Jeffrey K.; Berenberg, Jeffrey L.; Kesler, Shelli R.; Mustian, Karen M.

doi:10.1007/s00520-017-4013-0

Cited by 244 publications

(306 citation statements)

References 42 publications

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“…Overall, exercise can reduce symptoms of CIPN especially in breast cancer patients. In line with this, a multicenter RCT with a 6-week standardized and home-based progressive walking and resistance exercise intervention with moderate intensity could improve CIPN symptoms in 355 cancer patients receiving taxane-, platinum-, or vinca alkaloid-based chemotherapy [35]. Cancer-Related Cognitive Impairment A systematic review with 19 studies (rodents and humans) presented that physical activity such Asian-influenced movement programs could have a positive influence on self-perceived cognitive functions in patients with breast cancer in aftercare; it may also reduce chronic inflammation [36].…”

Section: Chemotherapy-induced Peripheral Neuropathymentioning

confidence: 81%

Physical Activity, Exercise and Breast Cancer - What Is the Evidence for Rehabilitation, Aftercare, and Survival A Review

Wirtz

Baumann

2018

Breast Care

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The current scientific field of exercise interventions in breast cancer is very large. Rehabilitation focuses on restoring or improving quality of life and thus on independence and participation in life. Hence, it is important to investigate exercise interventions in the setting of rehabilitation and aftercare. It is also necessary to determine the influence of physical activity or exercise therapy on the prevention of recurrence and mortality as well as on certain side effects of the disease and its medical treatment in rehabilitation. Physical activity in rehabilitation and aftercare is feasible and safe and can be used for various purposes. Against the background of reduced fatigue, chemotherapy-induced peripheral neuropathy, cancer-related cognitive impairment, arthralgia, lymphedema, recurrence, and mortality, as well as improved quality of life, different methodological approaches and evidence can be seen. Although the overall data availability has increased, there are gaps in study documentation as well as inadequate verification of scientific approaches in rehabilitation clinics and in everyday life.

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Section: Chemotherapy-induced Peripheral Neuropathymentioning

confidence: 81%

Physical Activity, Exercise and Breast Cancer - What Is the Evidence for Rehabilitation, Aftercare, and Survival A Review

Wirtz

Baumann

2018

Breast Care

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“…Vallance & Bolam [2], and Drs. Crevenna & Keilani [3] for bringing attention to the study of exercise for chemotherapy-induced peripheral neuropathy (CIPN) and for commending our recently published research [4]. The authors raise important points that indicate their expertise, their careful evaluation of our work, and their earnestness to advance the study and treatment of CIPN.…”

Section: Dear Editormentioning

confidence: 99%

Response to Crevenna and Ashbury, Vallance and Bolam, and Crevenna and Keilani regarding the effects of exercise on chemotherapy-induced peripheral neuropathy

Kleckner

Kamen

Gewandter

et al. 2018

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“…Owing to this fact, there is a lack of strong scientific evidence about its specific usefulness in the treatment of CIPN. Nevertheless, the number of studies showing the effectiveness of physical exercise and functional training (e.g., vibration training) is increasing [32, 33]. To improve coordination, sensorimotor function, and fine motor function the training should begin with the onset of manifest CIPN at the latest.…”

Section: Treatment Of Cipnmentioning

confidence: 99%

Prevention and Management of Chemotherapy-Induced Polyneuropathy

et al. 2019

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Chemotherapy-induced peripheral neurotoxicity (CIPN) is a severe and common side effect caused by a variety of antineoplastic agents. Approximately 30–40% of patients treated with agents such as taxanes, vinca alkaloids, or platinum derivatives will develop CIPN. CIPN presents predominantly as a sensory axonal neuro(no)pathy with occasional motor and autonomic dysfunction exhibiting considerable variability of clinical symptoms ranging from mild tingling sensation to severe neuropathic pain. Typical symptoms include numbness (“minus symptom”), weakness, and abnormal gait as well as paresthesia and pain (“positive symptoms”). As CIPN symptoms potentially lead to long-term morbidity and can even aggravate after cessation of therapy, patients’ quality of life can be tremendously affected. In view of improved breast cancer survival outcomes, the late effects of CIPN are an unmet need in these patients. Therefore, early detection and assessment of first symptoms is important to effectively prevent severe CIPN. Therapeutic options for patients with CIPN are still limited, and pharmacological treatment focuses primarily on reduction or relief of neuropathic pain. CIPN is usually acutely managed by dose reduction or discontinuation of causative chemotherapy, potentially compromising treatment outcome. Currently, there is no causative proven therapy for the prevention of CIPN.

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Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial

Abstract: Clinical Trials.gov , # NCT00924651, http://www.clinicaltrials.gov .

Cited by 244 publications

References 42 publications

Physical Activity, Exercise and Breast Cancer - What Is the Evidence for Rehabilitation, Aftercare, and Survival A Review

Physical Activity, Exercise and Breast Cancer - What Is the Evidence for Rehabilitation, Aftercare, and Survival A Review

Response to Crevenna and Ashbury, Vallance and Bolam, and Crevenna and Keilani regarding the effects of exercise on chemotherapy-induced peripheral neuropathy

Prevention and Management of Chemotherapy-Induced Polyneuropathy

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