Effects of exercise exposure on toxic interactions between inhaled oxidant and aldehyde air pollutants

Mautz, William J.; Kleinman, Michael T.; Phalen, Robert F.; Crocker, T. Timothy

doi:10.1080/15287398809531198

Cited by 28 publications

(11 citation statements)

References 45 publications

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Section: Ozone and Nitrogen Oxidesmentioning

confidence: 99%

“…Decades ago, Mautz et al (1988) were able to show synergistic toxic responses in mice exposed to these pollutants. Since ozone and NO 2 will form nitric acid vapour and nitrate radicals, the synergistic effects were explained by chemical interactions (Mautz et al, 1988). Various chemical compounds, as well as allergenic proteins, are efficiently oxygenated and nitrated upon exposure to ozone and NO 2 , which leads to an enhancement of their toxicity and allergenicity (Shiraiwa, Selzle & Pöschl, 2012).…”

Section: Ozone and Nitrogen Oxidesmentioning

confidence: 99%

See 1 more Smart Citation

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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Section: Ozone and Nitrogen Oxidesmentioning

confidence: 99%

Section: Ozone and Nitrogen Oxidesmentioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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show abstract

“…Measurement of the lung lesion density was done according to the method described by Mautz et al (30). Briefly, HEstained sections were viewed under a light microscope at a total magnification of ×100.…”

Section: Histopathological Evaluation Of Lung Injurymentioning

confidence: 99%

Effects of Granulocyte Colony-Stimulating Factor (G-CSF) on Bleomycin-Induced Lung Injury of Varying Severity

Adachi¹,

Suzuki²,

Sugimoto³

et al. 2003

Toxicol Pathol

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We evaluated the effects of granulocyte colony-stimulating factor (G-CSF) on bleomycin (BLM)-induced lung injury that developed diffuse alveolar damage and subsequent pulmonary fibrosis (PF) of varying severity. G-CSF (100 µg/kg/day) was administered subcutaneously to BLM (0.2, 20, 2,000 µg)-treated or -untreated rats for 3 or 14 days. In the BLM 0.2 µg group, slight alveolar mononuclear cell infiltration was observed, although PF was not noted. In the BLM 20-µg and 2,000-µg groups, diffuse alveolar damage along with neutrophil infiltration and subsequent PF were observed. In the saline + G-CSF group and BLM 0.2 µg + G-CSF group, a marked increase in the number of alkaline phosphatase (ALP)-positive neutrophils was noted in the alveolar capillaries, although there was neither neutrophil infiltration in alveoli nor exacerbation of lung injury. In the BLM 20 µg + G-CSF and BLM 2,000 µg + G-CSF groups, an exacerbation of lung injury along with an increase in the number of ALP-positive neutrophils in the alveoli was observed. These results indicate that the administration of G-CSF to rats with slight lung injury bearing no PF does not exacerbate the lung injury. The exacerbating effects of G-CSF seem to be associated not only with the marked infiltration of activated neutrophils but also with the severity of underlying lung injury.

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“…Measurement of the lung lesion density was done according to the method described by Mautz et al (1988) and Adachi et al (2003). Briefly, HE-stained sections were viewed under a light microscope at a total magnification of ×100.…”

Section: Pathological Examinationmentioning

confidence: 99%

Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats

et al. 2010

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-Interstitial lung disease has been reported in cancer patients treated with epidermal growth factor receptor tyrosine kinase inhibitors, erlotinib and gefitinib. Preclinical safety studies with erlotinib did not show any evidence for an induction of injury on intact lungs in rats and dogs. In the present study, we investigated the effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats. In Experiment 1, we examined the effects of short-term (7-and 21-day) administration of erlotinib (10 mg/kg/day, p.o.; subtoxic dose) on the BLM (0.1 or 0.6 mg/rat)-induced lung injury of slight and moderate severity. In Experiment 2, we examined the effects of long term (up to 63-day) administration of higher-dose (up to 20 mg/kg/day; toxic dose; accompanied with decreased body weight gain and severe skin lesions) erlotinib on the BLM-induced lung injury. In rats receiving erlotinib alone, no lung lesions were noted. In rats receiving BLM alone, diffuse alveolar damage (DAD) and, subsequently, pulmonary fibrosis of slight or moderate severity was observed. The administration of erlotinib to BLM-treated rats showed no exacerbation of lung injuries in indices such as macroscopic findings, lung weights, histopathological scores (lung lesion density and lung fibrosis score), and pulmonary hydroxyproline (HyP) level. These results suggest that erlotinib does not have any exacerbating effects on lung injuries induced by BLM in rats.

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Effects of exercise exposure on toxic interactions between inhaled oxidant and aldehyde air pollutants

Abstract: Respiratory tract injury resulting from inhalation of mixtures of ozone (O 3 ) and nitrogen dioxide (NO 2

Cited by 28 publications

References 45 publications

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Effects of Granulocyte Colony-Stimulating Factor (G-CSF) on Bleomycin-Induced Lung Injury of Varying Severity

Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats

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