Effects of exercise in patients with connective tissue disease receiving high-dose glucocorticoids: A pilot prospective cohort study

Nagashima, Masaaki; Takahashi, Daiki; Mizushima, Takashi; Yamauchi, K.

doi:10.1007/s00421-021-04697-2

Cited by 7 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Physical therapy is useful in improving physical function and ADL in these medical conditions. [15][16][17] The efficacy of exercise therapy is well known in the rehabilitation therapy of cancer patients undergoing chemotherapy; even lowintensity exercise therapy is effective. 18) A rehabilitation program adapted to the general condition and respiratory status has been recommended for COVID-19 patients.…”

Section: Discussionmentioning

confidence: 99%

Physical Therapy for a Multiple Myeloma Patient with COVID-19: A Case Report

Osaki

Morishita

Shimokawa

et al. 2023

PRM

View full text Add to dashboard Cite

Cancer patients are at significantly increased risk for coronavirus disease 2019 (COVID-19), 1) and at high risk of severe disease. 1,2) In particular, patients with hematological malignancies are at high risk of infection, severe disease, and death from COVID-19. 3) Patients with hematological malignancies, especially lymphoid malignancies, or patients undergoing chemotherapy, have impaired immune responses to the virus and its vaccine. 4,5) Therefore, treatment of COVID-19 for such patients tends to be prolonged and is conducted in an isolated environment.Patients with hematological malignancies have poor physical function and poor levels of physical activity. [6][7][8] Those with moderate-to-severe COVID-19 experience respiratory failure and decreased physical activity, which result in func-

show abstract

Section: Discussionmentioning

confidence: 99%

Physical Therapy for a Multiple Myeloma Patient with COVID-19: A Case Report

Osaki

Morishita

Shimokawa

et al. 2023

PRM

View full text Add to dashboard Cite

show abstract

“…The effect of exercise was not discussed separately in this study. Nonetheless, previous studies suggested that exercise therapy was beneficial to CTD patients and moderates the side effects of high-dose glucocorticoid treatment (46)(47)(48). The influence of exercise on right heart remodeling and finding an appropriate kinesitherapy in CTD patients are worth exploring.…”

Section: Association Between Sua and Right Cardiac Chamber Remodelingmentioning

confidence: 99%

Association of serum uric acid with right cardiac chamber remodeling assessed by cardiovascular magnetic resonance feature tracking in patients with connective tissue disease

Tang,

Yang,

Wen

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundRight cardiac chamber remodeling is widespread in patients with connective tissue disease (CTD). Serum uric acid (SUA) is considered a potential independent risk factor for cardiovascular disease, and elevated SUA levels are often observed in patients with CTD. The correlation between SUA levels and right cardiac chamber remodeling remains unclear. This study investigated the association of SUA with right cardiac chamber remodeling as assessed by cardiac magnetic resonance feature-tracking (CMR-FT) in CTD patients.Methods and resultsIn this cross-sectional study, a total of 104 CTD patients and 52 age- and sex-matched controls were consecutively recruited. All individuals underwent CMR imaging, and their SUA levels were recorded. The patients were divided into three subgroups based on the tertiles of SUA level in the present study. CMR-FT was used to evaluate the right atrial (RA) longitudinal strain and strain rate parameters as well as right ventricular (RV) global systolic peak strain and strain rate in longitudinal and circumferential directions for each subject. Univariable and multivariable linear regression analyses were used to explore the association of SUA with RV and RA strain parameters. Compared with the controls, the CTD patients showed significantly higher SUA levels but a lower RV global circumferential strain (GCS) and RA phasic strain parameters (all p < 0.05), except the RA booster strain rate. RV GCS remained impaired even in CTD patients with preserved RV ejection fraction. Among subgroups, the patients in the third tertile had significantly impaired RV longitudinal strain (GLS), RV GCS, and RA reservoir and conduit strain compared with those in the first tertile (all p < 0.05). The SUA levels were negatively correlated with RV GLS and RV GCS as well as with RA reservoir and conduit strain and strain rates (the absolute values of β were 0.250 to 0.293, all P < 0.05). In the multivariable linear regression analysis, the SUA level was still an independent determinant of RA conduit strain (β = -0.212, P = 0.035) and RV GCS (β = 0.207, P = 0.019).ConclusionSUA may be a potential risk factor of right cardiac chamber remodeling and is independently associated with impaired RA conduit strain and RV GCS in CTD patients.

show abstract

“…Glucocorticoids cause increased protein catabolism through increased transcription of proteolytically active enzymes and also reduce protein synthesis (14,15). Physical activity can be effective in preventing the development of steroid myopathy (16)(17)(18). In order to establish how much activity can actually be implemented during the inpatient time, it is important to monitor the activity and document the exercises as well as monitoring muscle function by assessing motor skills and grip strength.…”

Section: Introductionmentioning

confidence: 99%

Monitoring of strength, inflammation and muscle function in allogenic stem-cell transplantation patients – a pilot study for novel biomarker and risk stratification determination

Schulz,

Bizjak,

Moebes

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

BackgroundLow aerobic capacity is associated with an increased mortality risk in allogenic stem-cell transplantation (alloSCT) patients, but currently used risk scores in the pre-transplantation workup are still underestimating physical activity as a prognostic factor.AimTo examine the physical condition, muscle function, blood inflammation and training adherence of alloSCT patients during inpatient time to identify potential biomarkers associated with development of myopathy and sarcopenia.MethodsPatients undergoing alloSCT were examined at four time points (T0: before alloSCT; Tha: hospital admission; T1: engraftment; T2: inpatient discharge). T0 included cardiopulmonary performance, body composition, grip and knee strength, motor skill tests (One-leg stand/Tinetti/Chair-rising), blood sampling (blood cell profiling and inflammation targets (Kynurenin/high sensitivity C-reactive Protein (hsCRP)/Tumor necrosis factor alpha (TNF-alpha)/Musclin/Galectin-3) and quality of life, state of health, fatigue, muscle weakness and physical activity by questionnaires (IPAQ/BSA/SARC-F/Fatigue). At T1 and T2, blood samples, grip strength and motor skill tests were repeated. Glucocorticoid dose and daily physical activity were documented during inpatient stay.Results26 of 35 included patients (4 females; age 55.58 ± 12.32 years; BMI 24.70 ± 3.27 kg/m2; VO2peak 16.55 ± 4.06 ml/min/kg) could proceed to alloSCT. Grip strength and Tinetti decreased from T0 until T2, no difference in Chair-rising test, One-leg and Tandem stand. All patients engrafted after 24.9 days ± 3.9 days. HsCRP and Kynurenine increased from T0 to T1, decreased at T2. TNF-alpha (T0vsT2/T1vsT2) and Musclin (T0vsT1) decreased. At T2, Galectin-3 was higher compared to T0/T1. Correlation analysis of grip strength and inflammatory markers revealed a positive correlation with TNF-alpha at T2. 50% of patients documented physical activity and questionnaire and reported a 50%-reduction of daily endurance and strength training between T1 to T2.ConclusionAllogeneic stem-cell transplantation is associated with immune system vulnerability due to conditioning, increased inflammation and fatigue, and loss of muscle strength and function. In addition to hsCRP, Kynurenine seems to be a reliable biomarker to monitor acute and regenerative inflammation status of alloSCT patients, while Musclin and Galectin-3 may be added to physiological assessment regarding myopathy and sarcopenia. Grip strength and daily activity level should be documented by professionals to identify risk patients early and support them with optimal (exercise) therapy.

show abstract

Effects of exercise in patients with connective tissue disease receiving high-dose glucocorticoids: A pilot prospective cohort study

Cited by 7 publications

References 33 publications

Physical Therapy for a Multiple Myeloma Patient with COVID-19: A Case Report

Physical Therapy for a Multiple Myeloma Patient with COVID-19: A Case Report

Association of serum uric acid with right cardiac chamber remodeling assessed by cardiovascular magnetic resonance feature tracking in patients with connective tissue disease

Monitoring of strength, inflammation and muscle function in allogenic stem-cell transplantation patients – a pilot study for novel biomarker and risk stratification determination

Contact Info

Product

Resources

About