Effects of exercise-induced stress and dexamethasone on plasma hormone and glucose concentrations and sedation in dogs treated with dexmedetomidine

Raekallio, Marja; Kuusela, Erja; Lehtinen, Milla E; Tykkyläinen, Marja K; Huttunen, Pirkko; Westerholm, Fia C

doi:10.2460/ajvr.2005.66.260

Cited by 12 publications

(7 citation statements)

References 15 publications

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“…This finding most likely reflects normal physiology as the serum glucagon concentration decreased in response to the increase in blood glucose concentration. Previous studies in cats 15 and dogs 8,26 did not demonstrate a significant effect of α2-agonists on serum cortisol concentration. There was also no significant effect of dexmedetomidine upon serum cortisol concentrations in this study.…”

Section: Discussionmentioning

confidence: 74%

Effects of dexmedetomidine on glucose homeostasis in healthy cats

Bouillon

Duke

Focken

et al. 2019

Journal of Feline Medicine and Surgery

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Objectives Alpha(α)2-agonist administration has been documented to increase blood glucose concentrations in many species. The aim of this study was to further describe the effect of dexmedetomidine on glucose and its regulatory hormones in healthy cats. Methods A randomized crossover study using eight healthy cats with a 14 day washout period was used to assess the effect of dexmedetomidine (10 μg/kg IV) and saline on glucose, cortisol, insulin, glucagon and non-esterified fatty acid (NEFA) concentrations at 0, 20, 60, 120 and 180 mins post-administration. Glucose:insulin ratios were calculated for each time point. Results Within the dexmedetomidine group, significant differences ( P <0.05) were detected: increased median (range) blood glucose concentrations at 60 mins (11.55 mmol/l [5.9–16.6 mmol/l]) and 120 mins (12.0 mmol/l [6.1–13.8 mmol/l]) compared with baseline (6.05 mmol/l [4.8–13.3 mmol/l]); decreased glucagon concentrations at 120 mins (3.8 pmol/l [2.7–8.8 pmol/l]) and 180 mins (4.7 pmol/l [2.1–8.2 pmol/l]) compared with baseline (11.85 pmol/l [8.3–17.2 pmol/l]); decreased NEFA concentrations at 60 mins (0.281 mmol/l [0.041–1.357 mmol/l]) and 120 mins (0.415 mmol/l [0.035–1.356 mmol/l]) compared with baseline (0.937 mmol/l [0.677–1.482 mmol/l]); and significantly larger ( P <0.05) glucose:insulin ratios at 60 mins compared with baseline. Insulin and cortisol concentrations were not significantly changed after dexmedetomidine administration. Conclusions and relevance Feline practitioners should be aware of the endocrine effects associated with the use of α2-agonists, particularly when interpreting blood glucose concentrations. The transient effects of dexmedetomidine on glucose homeostasis are unlikely to significantly affect clinical practice.

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Section: Discussionmentioning

confidence: 74%

Effects of dexmedetomidine on glucose homeostasis in healthy cats

Bouillon

Duke

Focken

et al. 2019

Journal of Feline Medicine and Surgery

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“…Additionally, samples should be obtained at the same time of day to avoid possible diurnal variability [69]. These samples may be affected by daily experience, including sleep patterns, meal content, and recent exercise [69–71]. …”

Section: Quantification Of Stressmentioning

confidence: 99%

Psychogenic Stress in Hospitalized Dogs: Cross Species Comparisons, Implications for Health Care, and the Challenges of Evaluation

Hekman

Karas

Sharp

2014

Animals

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Evidence to support the existence of health consequences of psychogenic stress has been documented across a range of domestic species. A general understanding of methods of recognition and means of mitigation of psychogenic stress in hospitalized animals is arguably an important feature of the continuing efforts of clinicians to improve the well-being and health of dogs and other veterinary patients. The intent of this review is to describe, in a variety of species: the physiology of the stress syndrome, with particular attention to the hypothalamic-pituitary-adrenal axis; causes and characteristics of psychogenic stress; mechanisms and sequelae of stress-induced immune dysfunction; and other adverse effects of stress on health outcomes. Following that, we describe general aspects of the measurement of stress and the role of physiological measures and behavioral signals that may predict stress in hospitalized animals, specifically focusing on dogs.

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“…Patients that did not respond to this rescue medication were considered a treatment failure and were taken out of the study. Depth of sedation was scored concurrently with each pain assessment using an adapted recognized scoring system (4,5). The same investigator scores all animals for pain and sedation throughout the study.…”

Section: Use Of 20% Human Serum Albumin Results In 25 Critically Illmentioning

confidence: 99%

International Veterinary Emergency Critical Symposium Abstracts San Antonio, Texas, USA September 17–21, 2006

2006

J Vet Emergen Crit Care

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Effects of exercise-induced stress and dexamethasone on plasma hormone and glucose concentrations and sedation in dogs treated with dexmedetomidine

Abstract: Pretreatment with dexamethasone, moderate physical stress (exercise), or both did not influence sedation or cause adverse effects in healthy dogs treated with DEX.

Cited by 12 publications

References 15 publications

Effects of dexmedetomidine on glucose homeostasis in healthy cats

Effects of dexmedetomidine on glucose homeostasis in healthy cats

Psychogenic Stress in Hospitalized Dogs: Cross Species Comparisons, Implications for Health Care, and the Challenges of Evaluation

International Veterinary Emergency Critical Symposium Abstracts San Antonio, Texas, USA September 17–21, 2006

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