Effects of Exercise Intervention on Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis of Controlled Trials

Lu, Ming‐Chi; Koo, Malcolm

doi:10.3390/healthcare9091215

Cited by 12 publications

(7 citation statements)

References 40 publications

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“…Exercise has been shown to cause advantageous effects on the cardiovascular system in SLE patients such as reduced vascular stiffness, 3,37 to improve physical health-related quality of life 38 and to improve fatigue, 3 amongst others. 39 In the U.S.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects associated to a healthy lifestyle in systemic lupus erythematosus: A cross-sectional study

Vordenbäumen

Kleefisch

Sokolowski

et al. 2023

Lupus

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Objective To assess whether a healthy lifestyle is associated to beneficial effects on various systemic lupus erythematosus (SLE) health domains. Methods In a cross-sectional study, Mediterranean Diet Adherence Score (MEDAS), physical activity energy expenditure (PAEE), and smoking status were assessed by questionnaires, along with clinical parameters and various health domains including Systemic Lupus Disease Activity Score (SLEDAI), Depression Scale (CES-D), Fatigue Severity (FSS), functional status (FFbH), physical and mental quality of life (PCS, MCS). Lifestyle choices were assessed with respect to health domains by linear regression modeling. Additionally, SLE patients with a healthy lifestyle (MEDAS ≥ 4, ≥ 1 h sport per week, no smoking) were compared to those without by Wilcoxon’s signed-rank test. Results 49 of 145 SLE patients (44.3 ± 31.7 years, 87.6% female) followed a healthy lifestyle and showed a higher physical quality of life (β = 4.5 (95%-CI 1.5–7.9) p = 0.01), lower depression (β = −5.0 (−8.2 to −0.2) p = 0.02) and lower fatigue (β = −0.8 (−1.5 to −0.2) p = 0.01) independently of SLE disease activity. Furthermore, dsDNA-antibodies were lower (146 ± 540 vs 266 ± 146 U/mL, p = 0.049). In a more detailed analysis, physical activity had the highest impact on the various health domains when compared to smoking or diet adherence, which was consistent even after adjusting for multiple potential confounders. Each 1,000 kcal of weekly PAEE was associated to a 1.8 (0.9–2.6) point increase in the PCS ( p = 0.0001), a 0.2 (0.03–0.4) point decrease in the CES-D ( p = 0.01) and a 2.8 (1.2–4.4) point increase in the FFbH ( p = 0.0006). Conclusion A healthy lifestyle, especially physical activity is associated with beneficial effects including quality of life, depression and fatigue in SLE.

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Section: Discussionmentioning

confidence: 99%

Beneficial effects associated to a healthy lifestyle in systemic lupus erythematosus: A cross-sectional study

Vordenbäumen

Kleefisch

Sokolowski

et al. 2023

Lupus

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“…Our study uncovered a positive correlation between the total psychological capital score of SLE patients and their QOL. 41 Psychological capital is a valuable psychological resource that plays an invaluable role when patients face life and work difficulties. 42 This enables patients to overcome challenges and approach current predicaments with a more positive psychological state.…”

Section: Discussionmentioning

confidence: 99%

Positive psychological capital, post-traumatic growth, social support, and quality of life in patients with systemic lupus erythematosus: A cross-sectional study

Meng,

Gao,

Wang

et al. 2024

Lupus

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Objective This study aimed to investigate the correlation between positive psychological capital, post-traumatic growth, social support, and quality of life (QOL) in patients with systemic lupus erythematosus (SLE). Methods A cross-sectional study was conducted at the First Affiliated Hospital of Xinjiang Medical University from October 2022 to May 2023. A sample of 330 hospitalized SLE patients was selected for this study. The collected data included demographic information, the SLE disease activity index, the Positive Mental Capital Questionnaire, the Chinese version of the Post-Traumatic Growth Scale, the Social Support Rating Scale, and the Chinese version of the Lupus Quality of Life Scale. Results The QOL score among the 330 SLE patients was measured as M(P25, P75) of 105 (83.00,124.00). Positive psychological capital, post-traumatic growth, and social support demonstrated significant positive correlations with the QOL in SLE patients ( p < 0.05). Multiple linear regression analysis revealed that literacy, disease level, disease duration, occupation, marital status, psychological capital, social support, and post-traumatic growth were influential factors associated with the QOL in SLE patients. Conclusion Medical professionals should be attentive to the psychological well-being of SLE patients and should consider implementing early psychological interventions. These interventions are crucial for enhancing the QOL for individuals diagnosed with SLE.

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“…Moderate to strong evidence existed in the literature for the benefits of physical activity and exercise for SLE and SSc patients, including documented benefits regarding HRQoL, fatigue and cardiovascular burden 33 91–104. Despite sparse evidence regarding smoking cessation for improving disease activity and treatment outcomes and avoidance of cold exposure for the prevention of Raynaud’s phenomenon, the task force agreed on the crucial importance of these two recommendations.…”

Section: Discussionmentioning

confidence: 99%

EULAR recommendations for the non-pharmacological management of systemic lupus erythematosus and systemic sclerosis

Parodis,

Girard-Guyonvarc’h,

Arnaud

et al. 2023

Ann Rheum Dis

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ObjectiveTo develop evidence-based recommendations for the non-pharmacological management of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc).MethodsA task force comprising 7 rheumatologists, 15 other healthcare professionals and 3 patients was established. Following a systematic literature review performed to inform the recommendations, statements were formulated, discussed during online meetings and graded based on risk of bias assessment, level of evidence (LoE) and strength of recommendation (SoR; scale A–D, A comprising consistent LoE 1 studies, D comprising LoE 4 or inconsistent studies), following the European Alliance of Associations for Rheumatology standard operating procedure. Level of agreement (LoA; scale 0–10, 0 denoting complete disagreement, 10 denoting complete agreement) was determined for each statement through online voting.ResultsFour overarching principles and 12 recommendations were developed. These concerned common and disease-specific aspects of non-pharmacological management. SoR ranged from A to D. The mean LoA with the overarching principles and recommendations ranged from 8.4 to 9.7. Briefly, non-pharmacological management of SLE and SSc should be tailored, person-centred and participatory. It is not intended to preclude but rather complement pharmacotherapy. Patients should be offered education and support for physical exercise, smoking cessation and avoidance of cold exposure. Photoprotection and psychosocial interventions are important for SLE patients, while mouth and hand exercises are important in SSc.ConclusionsThe recommendations will guide healthcare professionals and patients towards a holistic and personalised management of SLE and SSc. Research and educational agendas were developed to address needs towards a higher evidence level, enhancement of clinician–patient communication and improved outcomes.

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Effects of Exercise Intervention on Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis of Controlled Trials

Cited by 12 publications

References 40 publications

Beneficial effects associated to a healthy lifestyle in systemic lupus erythematosus: A cross-sectional study

Beneficial effects associated to a healthy lifestyle in systemic lupus erythematosus: A cross-sectional study

Positive psychological capital, post-traumatic growth, social support, and quality of life in patients with systemic lupus erythematosus: A cross-sectional study

EULAR recommendations for the non-pharmacological management of systemic lupus erythematosus and systemic sclerosis

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