Effects of Exercise Interventions in Older Adults with Knee Osteoarthritis

Messier, Stephen P.

doi:10.1007/s11420-011-9261-9

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…For example, treadmill exercise was shown to be effective in blocking OA-induced changes to cartilage and subchondral bone in a DMM model of OA [31]. Recent clinical reports have also indicated that moderate and high intensity exercise has beneficial effects by reducing pain scores in men and women with moderate to severe knee OA [32–34]. For example, a 5-year clinical study on Intensive Diet and Exercise for Arthritis (IDEA) showed that an intensive exercise regimen that included aerobic walking, strength training, a secondary aerobic session reduced joint loading and decreased plasma levels of the inflammatory biomarker IL-6 [34].…”

Section: Discussionmentioning

confidence: 99%

Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis

et al. 2017

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There is great interest in developing and utilizing non-pharmacological/non-invasive forms of therapy for osteoarthritis (OA) pain including exercise and other physical fitness regimens. Aims The present experiments determined the effects of prior wheel running on OA-induced weight asymmetry and trabecular bone microarchitecture. Main methods Wheel running included 7 or 21 days of prior voluntary access to wheels followed by OA induction, followed by 21 days post-OA access to wheels. OA was induced with monosodium iodoacetate (MIA), and weight asymmetry was measured using a hind limb weight bearing apparatus. Bone microarchitecture was characterized using ex vivo μCT. Key findings Relative to saline controls, MIA (3.2 mg/25 μl) produced significant weight asymmetry measured on post-days (PDs) 3, 7, 14, 21 in sedentary rats. Seven days of prior running failed to alter MIA-induced weight asymmetry. In contrast, 21 days of prior running resulted in complete reversal of MIA-induced weight asymmetry on all days tested. As a comparator, the opioid agonist morphine (3.2– 10 mg/kg) dose-dependently reversed weight asymmetry on PDs 3, 7, 14, but was ineffective in later-stage (PD 21) OA. In runners, Cohen’s d (effect sizes) for OA vs. controls indicated large increases in bone volume fraction, trabecular number, trabecular thickness, and connective density in lateral compartment, and large decreases in the same parameters in medial compartment. In contrast, effect sizes were small to moderate for sedentary OA vs. controls. Significance Results indicate that voluntary exercise may protect against OA pain, the effect varies as a function of prior exercise duration, and is associated with distinct trabecular bone modifications.

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Section: Discussionmentioning

confidence: 99%

Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis

et al. 2017

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“…It has been well documented that obese individuals diagnosed with knee OA tend to score poorly on performance-based tests of physical functioning and that they have higher levels of pain [7,61,62]. A previous study [61] compared obese control subjects with obese individual diagnosed with knee OA.…”

Section: Increase In Womac Scores After Performance-based Tests In Inmentioning

confidence: 99%

“…Physical activity and knee OA Studies using diet and exercise as part of an intervention to decrease disability in individuals with knee OA indicated that after losing weight and engaging in moderate levels of physical activity, obese individuals seem to improve on their levels of function and knee pain [7,14,29,67]. One particular study [67], found that after 18 months of exercise and diet followed by 5.7% of body weight loss, an obese group diagnosed with knee OA selfreported a significantly (p50.05) lower WOMAC pain score of 5.07 ± 0.47 (24% of pain improvement) and walked a significantly (p50.05) longer distance of 477 meters, measured with 6 MWT, compared to their baseline results (7.27 ± 0.41 and 416.1 ± 11.3).…”

Section: Increase In Womac Scores After Performance-based Tests In Inmentioning

confidence: 99%

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Changes in self-reported disability after performance-based tests in obese and non-obese individuals diagnosed with osteoarthritis of the knee

Coriolano

Aiken

Pukall

et al. 2014

Disability and Rehabilitation

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Obese individuals with knee OA may over-estimate their ability to perform physical activities, and may under-estimate their level of disability compared to non-obese individuals with knee OA. In addition, self-reported physical activity seems to be a strong indicator of disability in individuals with knee OA, particularly for individuals with a sedentary life style. Implications for Rehabilitation Osteoarthritis is a progressive joint disabling condition that restricts physical function and participation in daily activities, particularity in elderly individuals. Obesity is a comorbidity commonly associated with osteoarthritis and it appears to increase self-reported disability in those diagnosed with osteoarthritis of the knee. In a relatively small sample, this study recommends that rehabilitation professionals obtain self-report questionnaires of disability after performance-based tests in obese individuals with osteoarthritis of the knee as they are more likely to give an accurate representation of their level of ability at this time.

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Knee Osteoarthritis Prevalence in Hospitalized Elderly Patients: A Retrospective Study

Huang

Lin

et al. 2013

J Long Term Eff Med Implants

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This study aimed to determine the prevalence rate of knee osteoarthritis (OA) and the risk factors for OA in hospitalized elderly patients. We conducted this retrospective study in elderly patients (aged 65 years and older) who were hospitalized in the Geriatric Ward of General Hospital of Guangzhou Military Command of the People's Liberation Army between January 2011 and June 2013, including general condition, present history, past history, physical examination, X-ray results, and disease diagnosis. The prevalence, awareness, and treatment rates of knee OA in hospitalized elderly patients were calculated. Risk factors were computed using multiple logistic regression analysis. Of a total of 267 (17.4%) hospitalized elderly patients diagnosed with knee OA, the prevalence rate of OA was 9.95% in males and 37.76% in females. The rate of awareness among those with OA was 51.68%; the rate of treatment was 83.33%; and the rate of control was 77.39%. The medical expenses for both females (1143±315 yuan month-1) and males (1192±357 yuan month-1) in knee OA patients are higher than that of the non-knee OA group (989±274 yuan month-1, 1038±295 yuan month-1). The risk factors for knee OA include gender (OR=2.448), age (OR=1.124), transportation mode (OR= 8.972), exercise (OR=7.374), bowel evacuation position (OR=5.767), family history of knee OA (OR=2.195), and body mass index (OR=2.469). The prevalence of knee OA is unexpectedly high in hospitalized elderly patients, and the rates of awareness and treatment are less than desirable. Prevention and control measures should be taken in patients with concomitant risk factors.

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Effects of Exercise Interventions in Older Adults with Knee Osteoarthritis

Cited by 3 publications

References 11 publications

Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis

Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis

Changes in self-reported disability after performance-based tests in obese and non-obese individuals diagnosed with osteoarthritis of the knee

Knee Osteoarthritis Prevalence in Hospitalized Elderly Patients: A Retrospective Study

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