Effects of exercise interventions on executive function in old adults with mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials

Lin, Miaoran; Ma, Chuyi; Zhu, Jingfang; Gao, Jiahui; Huang, Li; Huang, Jia; Liu, Zhizhen; Tao, Jing; Chen, Lidian

doi:10.1016/j.arr.2022.101776

Cited by 10 publications

(2 citation statements)

References 102 publications

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“…Since the influential meta-analytic study conducted by Colcombe and Kramer [ 6 ], the effect of exercise on EFs and episodic memory has been examined in numerus meta-analyses [ 33 – 47 ]. However, some reviews included only healthy populations [ 39 , 40 , 46 ], while others included only cognitively impaired or demented older adults [ 34 , 35 , 41 , 43 , 44 , 48 ]. Chen et al [ 36 ] included both healthy and cognitively impaired older adults but not demented.…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic physical exercise on executive functions and episodic memory in clinical and healthy older adult populations: a systematic review and meta-analysis protocol

Ballesteros,

Audifren,

Badache

et al. 2024

Syst Rev

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Background Executive functions (EFs) and episodic memory are fundamental components of cognition that deteriorate with age and are crucial for independent living. While numerous reviews have explored the effect of exercise on these components in old age, these reviews screened and analyzed selected older adult populations, or specific exercise modes, thus providing only limited answers to the fundamental question on the effect of exercise on cognition in old age. This article describes the protocol for a systematic review and multilevel meta-analytic study aiming at evaluating the effectiveness of different types of chronic exercise in improving and/or maintaining EFs and long-term episodic memory in older adults. Methods and analysis The study protocol was written in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Several databases will be searched. Randomized controlled trials (RCTs) conducted in older adults aged ≥ 60 years providing any kind of planned, structured, and repetitive exercise interventions, and EFs and/or episodic memory measures as outcomes, published in English in peer-reviewed journals and doctoral dissertations will be included. Two independent reviewers will screen the selected articles, while a third reviewer will resolve possible conflicts. The Cochrane risk-of-bias tool will be used to assess the quality of the studies. Finally, data will be extracted from the selected articles, and the formal method of combining individual data from the selected studies will be applied using a random effect multilevel meta-analysis. The data analysis will be conducted with the metafor package in R. Discussion and conclusion This review will synthesize the existing evidence and pinpoint gaps existing in the literature on the effects of exercise on EFs and episodic memory in healthy and unhealthy older adults. Findings from this meta-analysis will help to design effective exercise interventions for older adults to improve and/or maintain EFs and episodic memory. Its results will be useful for many researchers and professionals working with older adults and their families. Systematic review registration PROSPERO CRD42022367111.

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Section: Introductionmentioning

confidence: 99%

Effects of chronic physical exercise on executive functions and episodic memory in clinical and healthy older adult populations: a systematic review and meta-analysis protocol

Ballesteros,

Audifren,

Badache

et al. 2024

Syst Rev

View full text Add to dashboard Cite

show abstract

“…Although the lack of evidence could be interpreted as discouraging, in our opinion this may be the results of the variations in methodology of the included studies rather than evidence of the lack of effect of lifestyle interventions. Previous research has demonstrated the positive effect of diets such as the Mediterranean diet on cognition [35] and physical activity on cognitive health outcomes [18] . Besides, it is also true that statistically significant study outcomes do not necessarily translate into meaningful clinical improvements.…”

Section: Discussionmentioning

confidence: 99%