Effects of exercise modality and intensity on the CD4 count in people with HIV: a systematic review and meta-analysis

Silva, Bruno Ferrari; Oliveira, Gustavo Henrique de Medeiros; Simões, Caroline Ferraz; Vissoci, João Ricardo Nickenig; Peres, Sidney Barnabé; Moraes, Solange Marta Franzói de

doi:10.1080/09540121.2021.1902932

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…Also, Poton, et al [34] using a recent meta-analysis examined the effects of resistance training in HIV-infected individuals and reported a potential moderate effect of such intervention on CD4 count. Based on subgroup analysis, Silva, et al [35] reported that only aerobic exercise proved to have a significant effect on CD4.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Cicek [20] observed a meaningful decrease in the values of RBC, HGB, HCT and MCV of the strength exercise group compared to aerobic exercise. In addition, Silva, et al [35] noted that when exercise intensities were stratified, only intense training proved to have a significant effect on CD4 count. The different study groups recruited by these authors could be a possible explanation for the statistically significant results observed by them.…”

Section: Discussionmentioning

confidence: 99%

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Haematological and CD4 Parameters of Young Sportspersons (Pre- and Post-Exercise) in Ambrose Alli University (AAU), Ekpoma, Nigeria

2022

AJBSR

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Haematological parameters are those parameters that are related to the blood and blood forming organs [5]. Haematological components which consist of red blood cells, white blood cells, platelet and certain ratios of these values are valuable is monitoring the health status of an individual [6]. Red blood cells (erythrocytes) serve as a carrier of oxygen. It is this haemoglobin that reacts with oxygen carried in the blood to form oxyhaemoglobin during respiration. Packed cell volume, haemoglobin and mean corpuscular

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Haematological and CD4 Parameters of Young Sportspersons (Pre- and Post-Exercise) in Ambrose Alli University (AAU), Ekpoma, Nigeria

2022

AJBSR

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“…It is well established that exercise leads to improvements across several physiological systems including cardiorespiratory fitness (ie, VO 2 max) and cardiometabolic health, improved body composition, muscular strength, function (both upper and lower body), and enhanced quality of life. [281][282][283] However, only ≈20% of PLWH meet current exercise recommendations based on self-report, 284 likely an overestimation of actual exercise and physical activity. Low-exercise uptake may be due to SDoH that limit accessibility.…”

Section: Role Of Exercise For Attenuating Hiv-related Vascular Aging ...mentioning

confidence: 99%

Exercise to Prevent Accelerated Vascular Aging in People Living With HIV

Jones,

Robinson,

Beach

et al. 2024

Circulation Research

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Given advances in antiretroviral therapy, the mortality rate for HIV infection has dropped considerably over recent decades. However, people living with HIV (PLWH) experience longer life spans coupled with persistent immune activation despite viral suppression and potential toxicity from long-term antiretroviral therapy use. Consequently, PLWH face a cardiovascular disease (CVD) risk more than twice that of the general population, making it the leading cause of death among this group. Here, we briefly review the epidemiology of CVD in PLWH highlighting disparities at the intersections of sex and gender, age, race/ethnicity, and the contributions of social determinants of health and psychosocial stress to increased CVD risk among individuals with marginalized identities. We then overview the pathophysiology of HIV and discuss the primary factors implicated as contributors to CVD risk among PLWH on antiretroviral therapy. Subsequently, we highlight the functional evidence of premature vascular dysfunction as an early pathophysiological determinant of CVD risk among PLWH, discuss several mechanisms underlying premature vascular dysfunction in PLWH, and synthesize current research on the pathophysiological mechanisms underlying accelerated vascular aging in PLWH, focusing on immune activation, chronic inflammation, and oxidative stress. We consider understudied aspects such as HIV-related changes to the gut microbiome and psychosocial stress, which may serve as mechanisms through which exercise can abrogate accelerated vascular aging. Emphasizing the significance of exercise, we review various modalities and their impacts on vascular health, proposing a holistic approach to managing CVD risks in PLWH. The discussion extends to critical future study areas related to vascular aging, CVD, and the efficacy of exercise interventions, with a call for more inclusive research that considers the diversity of the PLWH population.

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“…Recent systematic reviews and meta-analyses have reported that exercise is effective for enhancing various health outcomes in people living with HIV. Specifically, exercise improves cardiovascular parameters [ 20 ], lipid profiles and blood glucose [ 21 ], CD4 count [ 22 ], and depression and anxiety [ 23 , 24 ]. However, there is a lack of evidence regarding the importance of exercise for supporting the health of specific populations of people living with HIV, such as older adults and women [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Physical Activity Interventions on Health Outcomes among Older Adults Living with HIV: A Systematic Review and Meta-Analysis

Noh

2022

IJERPH

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There is a lack of evidence regarding the effects of exercise on older individuals living with HIV. This systematic review and meta-analysis examined previous studies on physical activity interventions for people living with HIV aged ≥50 years. The effectiveness of the interventions on various physical and psychological health outcomes was evaluated. Databases used for this review included PubMed, EMBASE, CINAHL, and Cochrane Library CENTRAL. Twelve randomized controlled trials on physical activity interventions for people ≥50 years and living with HIV were included. Standardized mean differences were calculated using random-effect models. All effect sizes were expressed using Cohen’s d values and their 95% confidence intervals (CIs). Physical activity interventions had a significant effect on walking capacity (Cohen’s d: 0.467; 95% CI [0.069, 0.865]). The effect sizes on cardiorespiratory fitness, weight, and health-related quality of life were not significant. These findings suggest that physical activity interventions for people living with HIV aged ≥50 years are effective for the improvement of walking capacity. Further larger and higher-quality studies are required to determine the full effects of physical activity interventions on various health outcomes among older adults with HIV.

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Effects of exercise modality and intensity on the CD4 count in people with HIV: a systematic review and meta-analysis

Cited by 3 publications

References 26 publications

Haematological and CD4 Parameters of Young Sportspersons (Pre- and Post-Exercise) in Ambrose Alli University (AAU), Ekpoma, Nigeria

Haematological and CD4 Parameters of Young Sportspersons (Pre- and Post-Exercise) in Ambrose Alli University (AAU), Ekpoma, Nigeria

Exercise to Prevent Accelerated Vascular Aging in People Living With HIV

Effects of Physical Activity Interventions on Health Outcomes among Older Adults Living with HIV: A Systematic Review and Meta-Analysis

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