Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

Hayashino, Yasuaki; Jackson, Jeffrey L.; Hirata, Takumi; Fukumori, Norio; Nakamura, Fumiaki; Fukuhara, Shunichi; Tsujii, Satoru; Ishii, Hitoshi

doi:10.1016/j.metabol.2013.08.018

Cited by 216 publications

(149 citation statements)

References 42 publications

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“…For example, Liukkonen et al (2007) showed that elevated levels of CRP found in association with sleep disturbance (ie, self-reported problems sleeping) were greater than elevated levels associated with sedentary physical activity, low socioeconomic status, and tobacco smoking, but not with elevated body mass index. Likewise, Christian (Christian et al, 2011) found that self-reported poor sleep quality was correlated with CRP and IL-6 at a magnitude comparable to that between age and these markers of inflammation, but less than that found between BMI and CRP or IL-6; these latter findings are similar to those reported by Friedman et al (2005) Alternatively, the absolute change in levels of CRP or IL-6 with a healthy diet intervention (Neale et al, 2016), or aerobic exercise (Hayashino et al, 2014), is comparable to the absolute difference found in association with sleep disturbance.…”

Section: Naturalistic Sleep Disturbance and Systemic Markers Of Inflamentioning

confidence: 61%

Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity

Irwin

Opp

2016

Neuropsychopharmacol

384

268

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Sleep disturbances including insomnia independently contribute to risk of inflammatory disorders and major depressive disorder. This review and overview provides an integrated understanding of the reciprocal relationships between sleep and the innate immune system and considers the role of sleep in the nocturnal regulation of the inflammatory biology dynamics; the impact of insomnia complaints, extremes of sleep duration, and experimental sleep deprivation on genomic, cellular, and systemic markers of inflammation; and the influence of sleep complaints and insomnia on inflammaging and molecular processes of cellular aging. Clinical implications of this research include discussion of the contribution of sleep disturbance to depression and especially inflammation-related depressive symptoms. Reciprocal action of inflammatory mediators on the homeostatic regulation of sleep continuity and sleep macrostructure, and the potential of interventions that target insomnia to reverse inflammation, are also reviewed. Together, interactions between sleep and inflammatory biology mechanisms underscore the implications of sleep disturbance for inflammatory disease risk, and provide a map to guide the development of treatments that modulate inflammation, improve sleep, and promote sleep health.

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Section: Naturalistic Sleep Disturbance and Systemic Markers Of Inflamentioning

confidence: 61%

Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity

Irwin

Opp

2016

Neuropsychopharmacol

384

268

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“…It is well-known that exercise reduces the risk of developing type 2 diabetes, improves glycemic control in patients with diabetes (39)(40)(41), and improves the symptoms of depression (42). Recently, our meta-analysis revealed that longterm exercise reduced CRP levels in patients with diabetes (43). Based on these previous reports, our results suggest that inflammatory cytokines specifically from adipose tissue may play an important role in the association between type 2 diabetes and major depression, and exercise seems to be a strong confounder in this association between inflammation and depression in these patients.…”

Section: Discussionmentioning

confidence: 92%

Elevated Levels of hs-CRP Are Associated With High Prevalence of Depression in Japanese Patients With Type 2 Diabetes: The Diabetes Distress and Care Registry at Tenri (DDCRT 6)

et al. 2014

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OBJECTIVEBecause of the absence of data on the direct association between inflammation and depression in patients with diabetes, we examined the association between hs-CRP levels and the high prevalence of depression in adult patients with type 2 diabetes. RESEARCH DESIGN AND METHODSCross-sectional data were obtained from 3,573 patients with type 2 diabetes recruited from a Japanese diabetes registry. A multiple logistic regression analysis adjusted for potential confounders was used to assess independent associations between hs-CRP levels and major depression, as defined by the Patient Health Questionnaire-9. RESULTSMean age, BMI, and HbA 1c levels were 66.0 years, 24.6 kg/m 2 , and 7.4% (57.8 mmol/mol), respectively, and 122 patients (3.4%) suffered from major depression. In the age-and sex-adjusted model, the odds ratio (OR) for major depression was 1.86 (95% CI 1.01-3.42; P = 0.045) in the highest CRP quintile compared with that in the 3rd CRP quintile; however, this association disappeared after adjustment for other possible confounders (OR 1.58 [95% CI 0.85-2.94]; P = 0.148). Among patients with a BMI of ‡25 kg/m 2 , a significant association was observed between the highest hs-CRP quintile and major depression (multivariable-adjusted OR 2.69 [95% CI 1.09-7.08]; P = 0.032). CONCLUSIONSWe observed a significant positive association between high hs-CRP levels and depression in patients with diabetes who had a high BMI.In the last decade, several studies have been published that suggest a close association between diabetes and depression. Patients with diabetes have a high prevalence of depression (1), particularly that associated with poor treatment adherence and glycemic control (1,2), and a high prevalence of complications (3). In addition, depression is associated with mortality in these patients (4).

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“…Previous reviews have been limited to individuals with diagnosed CVD and T2DM;14 79 however, age, gender, race, physical activity, obesity, oral contraceptive use and socioeconomic status have been associated with CRP in the absence of overt disease 7 80–85. In addition, there is some debate whether CRP is actively involved in the atherosclerotic process or serves as a biomarker of inflammation 86 87.…”

Section: Discussionmentioning

confidence: 99%