Effects of Exercise on Depression, Anxiety, Cognitive Control, Craving, Physical Fitness and Quality of Life in Methamphetamine-Dependent Patients

Huang, Junhao; Zheng, Yuqing; Gao, Dong-Dong; Hu, Min; Yuan, Ti‐Fei

doi:10.3389/fpsyt.2019.00999

Cited by 44 publications

(40 citation statements)

References 72 publications

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“…The association between alcohol craving and quality of life was previously studied by Herrold et al in war veterans demonstrating that high levels of craving were associated with poor perceived quality of life, bothmentally and physically (39). At the same time, improving the quality of life, for instance, through physical exercise, can play an important role in reducing craving and, therefore, conducts of abuse (40). Several studies have demonstrated that stress, negative mood, and craving could expose addicted patients to relapse and dropout from treatment (41).…”

Section: Discussionmentioning

confidence: 92%

Psychopathological Burden and Quality of Life in Substance Users During the COVID-19 Lockdown Period in Italy

et al. 2020

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Section: Discussionmentioning

confidence: 92%

Psychopathological Burden and Quality of Life in Substance Users During the COVID-19 Lockdown Period in Italy

et al. 2020

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“…Exercise can improve METH-dependent emotional state, cognitive control, and cravings [34]. Herein, eight weeks of aerobic combined with resistance exercise significantly reduced the anxiety and depression symptoms of METH withdrawal [35].…”

Section: The Effect Of Exercise On 5-ht Vas Craving Vas Control Impulsementioning

confidence: 86%

Exercise Regulates Peripheral Blood Serotonin to Improve the Addiction and Impulse of Methamphetamine Withdrawal Patients

Tang

Zheng

2021

Preprint

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Background: This study aimed to explore the effect of aerobic combined with resistance exercise on the level of 5-HT in the peripheral blood of methamphetamine (METH) withdrawal patients, improving cue-induced craving and impulse. Methods： Fifty methamphetamine withdrawal patients were included. The patients underwent eight weeks of aerobic combined with resistance exercise. The sessions lasted an hour and were conducted five times a week. Impulsivity (BIS-11), craving (VAS craving), and control (VAS control) were assessed before and after the intervention. ELISA was used to detect peripheral blood 5-HT levels. Results： The results showed that peripheral blood 5-HT and VAS control significantly increased after the exercise. In contrast, VAS craving and BIS-11 significantly decreased after the exercise. Conclusions： We present that eight weeks of aerobic combined with resistance exercise can alter the peripheral blood 5-HT levels of METH withdrawal patients and improve the cue-induced craving and impulse levels.

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“…As one of the most commonly abused psychostimulants in the world (Siefried et al, 2020), methamphetamine (METH) abuse results in various severe complications systemically affecting multiple organs, especially the brain (Casaletto et al, 2015;Huang et al, 2019). METH addiction can induce neurodegenerative changes in the hippocampus and frontal cortex, which are all related to long-term cognitive dysfunction and memory deficits in humans (Casaletto et al, 2015;Chen et al, 2015;Wang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Krill Oil Alleviated Methamphetamine-Induced Memory Impairment via the MAPK Signaling Pathway and Dopaminergic Synapse Pathway

Xiang

Xiong

et al. 2021

Front. Pharmacol.

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Methamphetamine (METH) abuse exerts severe harmful effects in multiple organs, especially the brain, and can induce cognitive dysfunction and memory deficits in humans. Krill oil is rich in polyunsaturated fatty acids, while its effect on METH-induced cognitive impairment and mental disorders, and the underlying mechanism remain unknown. The aim of the present study was to investigate the protective effect of krill oil on METH-induced memory deficits and to explore the molecular mechanisms by using an integrated strategy of bioinformatics analysis and experimental verification. METH-exposed mice were treated with or without krill oil. Learning and memory functions were evaluated by the Morris water maze. The drug–component–target network was constructed in combination with network pharmacology. The predicted hub genes and pathways were validated by the Western blot technique. With krill oil treatment, memory impairment induced by METH was significantly improved. 210 predicted targets constituted the drug–compound–target network by network pharmacology analysis. 20 hub genes such as DRD2, MAPK3, CREB, BDNF, and caspase-3 were filtered out as the underlying mechanisms of krill oil on improving memory deficits induced by METH. The KEGG pathway and GO enrichment analyses showed that the MAPK signaling pathway, cAMP signaling pathway, and dopaminergic synapse pathway were involved in the neuroprotective effects of krill oil. In the hippocampus, DRD2, cleaved caspase-3, and γ-H2AX expression levels were significantly increased in the METH group but decreased in the krill oil–treated group. Meanwhile, krill oil enhanced the expressions of p-PKA, p-ERK1/2, and p-CREB. Our findings suggested that krill oil improved METH-induced memory deficits, and this effect may occur via the MAPK signaling pathway and dopaminergic synapse pathways. The combination of network pharmacology approaches with experimental validation may offer a useful tool to characterize the molecular mechanism of multicomponent complexes.

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Effects of Exercise on Depression, Anxiety, Cognitive Control, Craving, Physical Fitness and Quality of Life in Methamphetamine-Dependent Patients

Cited by 44 publications

References 72 publications

Psychopathological Burden and Quality of Life in Substance Users During the COVID-19 Lockdown Period in Italy

Psychopathological Burden and Quality of Life in Substance Users During the COVID-19 Lockdown Period in Italy

Exercise Regulates Peripheral Blood Serotonin to Improve the Addiction and Impulse of Methamphetamine Withdrawal Patients

Krill Oil Alleviated Methamphetamine-Induced Memory Impairment via the MAPK Signaling Pathway and Dopaminergic Synapse Pathway

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