Effects of exercise on platelet function, coagulation, and fibrinolysis

Changes in platelet count and related parameters in SART-stressed mice and the action of administered neurotropin.

“…Numerous clinical investigations have shown that stress can cause quantitative and/ or qualitative alterations in human platelets (1,3,(22)(23)(24)(25)(26).…”

“…There is also some evidence to suggest that platelet adhesiveness and/or aggregability may transiently increase following exercise and acute mental stress (1,25,26). In laboratory animals, however, studies con cerning the relation between stress and platelets have been comparatively few, al though some investigators have reported that some special forms of stress such as hypoxia (27), magnetic fields (28) and hypo thermia (29) lead to thrombocytopenia.…”

Exercise-induced Changes in the Clotting Times and Fibrinolytic Activity during Official 1600 and 2 000 Meters Trot Races in the Standardbred Horses

“…The increase in clotting and fibrinolytic activity due to exercise has been widely documented in humans, both for maximal (Dufaux et al 1991;L i n et al 1999;Van den Burg et al 2000;H ilb e rg et al 2003) and near-maximal efforts (Prisco et al 1998;Hegde et al 2001); in this species, a direct correlation between fibrinolysis and the exercise intensity has been observed (Ferguson et al 1987). The increased fibrinolytic activity appears to counterbalance the exercise-induced increase in coagulability (Colwell 1986). As regards the equine species, data available on the effects of exercise on the clotting times are not univocal: some researchers have found evidence of fibrinogen degradation with physical activity (Marsh and Gaffney 1980), whereas others have not demonstrated a difference in coagulability or in fibrinolysis (Bayly et al 1983ab).…”

Blood Coagulation and Fibrinolysis in SART-Stressed (Repeated Cold-Stressed) Rats and Drug Effects on the Altered Hemostatic Parameters.

“…Some types of acute stress, including emotional stress and exercise, can affect the number and/or function of blood platelets, coagulation and fibrinolysis in humans (2,(4)(5)(6)(7). However, hemostatic altera tions under chronic stress have rarely been in vestigated, and there are few studies on the relationship between stress and hemostasis in laboratory animals.…”