Effects of Exercise on Treatment-Related Adverse Effects for Patients With Prostate Cancer Receiving Androgen-Deprivation Therapy: A Systematic Review

Gardner, Jason R; Livingston, Patricia M.; Fraser, Steve F.

doi:10.1200/jco.2013.49.5523

Cited by 225 publications

(219 citation statements)

References 67 publications

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“…Of the sixteen rcts that measured muscular or aerobic fitness, or both 10,14,29,30,34,35,37,39,40,[44][45][46][47][48]52,54 , eleven found significant positive changes in the exercise groups 10,14,29,30,34,35,37,39,[44][45][46]48 . A systematic review found substantial increases in muscular strength and endurance with resistance training for patients on androgen deprivation therapy 21 .…”

Section: Muscular and Aerobic Fitnessmentioning

confidence: 99%

“…All systematic reviews found positive changes in both muscular and aerobic fitness 11,13,[15][16][17][18][19][20][21][22][23][24][25][26][27][28]55,56 . Of the sixteen rcts that measured muscular or aerobic fitness, or both 10,14,29,30,34,35,37,39,40,[44][45][46][47][48]52,54 , eleven found significant positive changes in the exercise groups 10,14,29,30,34,35,37,39,[44][45][46]48 .…”

Section: Muscular and Aerobic Fitnessmentioning

confidence: 99%

“…Fourteen systematic reviews found an improvement in qol for patients with cancer participating in an exercise intervention during the active treatment or post-treatment period 11,13,[15][16][17][18][19][20][21][22][23][24][25][26][27][28] . Of the sixteen studies involving patients in active treatment [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] , six demonstrated that, compared with the control group, the intervention group experienced significant improvements in qol 30,31,33,[38][39][40]43 .…”

Section: Quality Of Lifementioning

confidence: 99%

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Exercise for People with Cancer: A Clinical Practice Guideline

et al. 2017

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Background Development of this guideline was undertaken by the Exercise for People with Cancer Guideline Development Group, a group organized by Cancer Care Ontario’s Program in Evidence-Based Care (pebc). The purpose of the guideline was to provide guidance for clinicians with respect to exercise for patients living with cancer, focusing on the benefits of specific types of exercise, recommendations about screening requirements for new referrals, and safety concerns.Methods Consistent with the pebc’s standardized approach, a systematic search was conducted for existing guidelines, and systematic literature searches were performed in medline and embase for both systematic reviews and primary literature. Content and methodology experts performed an internal review, which was followed by an external review by targeted experts and intended users.Results The search identified three guidelines, eighteen systematic reviews, and twenty-nine randomized controlled trials with relevance to the topic. The present guideline provides recommendations for the duration, frequency, and intensity of exercise appropriate for people living with cancer. It also provides recommendations for pre-exercise assessment, safety concerns, and delivery models.Conclusions There is sufficient evidence to show that exercise provides benefits in quality of life and muscular and aerobic fitness for people with cancer both during and after treatment, and that it does not cause harm. The present guideline is intended to support the Canadian Society for Exercise Physiology’s Canadian physical activity guidelines. The recommendations are intended for clinicians and institutions treating cancer patients in Ontario, and for policymakers and program planners involved in the delivery of exercise programs for cancer patients.

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Section: Muscular and Aerobic Fitnessmentioning

confidence: 99%

Section: Muscular and Aerobic Fitnessmentioning

confidence: 99%

Section: Quality Of Lifementioning

confidence: 99%

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Exercise for People with Cancer: A Clinical Practice Guideline

et al. 2017

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“…Lifestyle modification and oral supplementation General measures for the management of osteoporosis in men include lifestyle modifications such as safe weight-bearing exercise, 27 moderate sun exposure, discouraged alcohol and smoking consumption and a balanced diet including calcium-rich foods. 28 In men undergoing ADT, supplementation Androgen deprivation therapy and bone loss Marc Bienz and Fred Saad of calcium and vitamin D should be considered and especially in men avoiding milk products, who have intestinal malabsorption, or in house-bound men such as those residing in homes for the elderly.…”

Section: Management Of Bone Loss During Adtmentioning

confidence: 99%

Androgen-deprivation therapy and bone loss in prostate cancer patients: a clinical review

Bienz¹,

Saad²

2015

BoneKEy Reports

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Androgen-deprivation therapy (ADT) has become a standard of care in the management of advanced prostate cancer or as an adjunct therapy. However, ADT is associated with a well-known deleterious effect on bone health, resulting in a decrease in bone-mass density (BMD) and increased risk for fracture. With the longer life expectancy of prostate cancer patients, improvement of the quality of life has become increasingly important. Therefore, adequate screening, prevention and treatment of BMD loss is paramount. Zoledronic acid and denosumab have shown promising results in recent studies, which has led to the Food and Drug Administration approval of these treatment options in various settings throughout the course of the disease, including the prevention of ADT-associated bone loss. This review focuses on the various parameters that impact BMD loss in men initiating ADT, on the specific effect of ADT on bone health and on various lifestyle modifications and treatment options such as bisphosphonates, osteoclast-targeted therapy and selective estrogen-receptor modulators that have shown promising results in recent studies.

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“…11 However, most of the published studies have a relatively small number of patients and short duration of intervention as well as follow -up.…”

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confidence: 99%

Supervised exercise to reduce cardiovascular morbidity of androgen deprivation therapy for prostate cancer

Wong¹

2017

Polish Archives of Internal Medicine

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EDITORIAL Supervised exercise to reduce cardiovascular morbidity of ADT 5 disease and diabetes was seen in patients who received GnRH agonists for a period as short as 1 to 4 months. Patients with preexisting heart disease are at even higher risk of cardiac events after using ADT. 6 Despite the findings of these observational studies, there is controversy with regard to the cardiovascular effects of ADT on patient survival. Randomized trials using ADT with radiation have failed to show an increase in cardiovascular death among men randomized to receive GnRH agonists. 7Exercise can mitigate the cardiovascular and metabolic side effects of ADT. In a study by Corme el al, 8 63 patients were randomized to either 3 months of supervised exercise or usual care at the time of initiation of ADT. At the end of the intervention, patients in the exercise group had better preservation of lean muscle mass, less gain in fat mass, and improved cardiovascular fitness. Gaskin et al 9 showed that a 12 -week community -based exercise program was feasible. Patients in the exercise group achieved significantly better 6 -minute walk test distance and other parameters of physical strength. In another randomized study, patients assigned to a 6 -month dietary and physical activity intervention achieved a significant reduction in weight, body mass index, and percentage fat mass compared with the usual -care group. 10A systematic review concluded that exercise training resulted in improvement in muscle strength, cardiorespiratory fitness, functional task performance, lean body mass, and fatigue. 11 However, most of the published studies have a relatively small number of patients and short duration of intervention as well as follow -up.In this issue of the Polish Archives of Internal Medicine (Pol Arch Intern Med), Hojan et al 12 reported the results of a randomized study to evaluate the effects of a 12 -month exercise program on inflammatory and cardiometabolic factors as well as functional status on patients receiving ADT and Prostate cancer (PA) is the most common cancer in men in the United States. With prostate--specific antigen (PSA) screening, most new cases are diagnosed at a localized stage with an excellent prognosis. As a result, the number of PA survivors has increased significantly. There were over 3.3 million PA survivors in the United States in 2016.1 More than 64% of them were older than 70 years of age, and many of them had medical comorbidities. A study by Epstein et al 2 concluded that men with PA in the United States have a higher chance of dying from other causes than cancer.2 Ischemic heart disease accounts for 24% of all deaths, compared to 16% from PA.Androgen deprivation therapy (ADT) is the main treatment for metastatic PA. More recently, the use of ADT has been expanded to include patients with localized disease. The current National Comprehensive Cancer Network guidelines (version 1.2017) include the options of external beam radiation with 4 to 6 months of ADT for intermediate -risk PA, and with 2 to 3 years of A...

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Effects of Exercise on Treatment-Related Adverse Effects for Patients With Prostate Cancer Receiving Androgen-Deprivation Therapy: A Systematic Review

Cited by 225 publications

References 67 publications

Exercise for People with Cancer: A Clinical Practice Guideline

Exercise for People with Cancer: A Clinical Practice Guideline

Androgen-deprivation therapy and bone loss in prostate cancer patients: a clinical review

Supervised exercise to reduce cardiovascular morbidity of androgen deprivation therapy for prostate cancer

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