Effects of exercise training during concomitant chemoradiation therapy in head-and-neck cancer patients: A systematic review

D’souza, Macrina; Samuel, Stephen Rajan; Saxena, PU Prakash

doi:10.4103/ijpc.ijpc_14_20

Cited by 6 publications

(8 citation statements)

References 9 publications

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“…Future cancer prevention and cancer survivorship programs should also focus on promoting strength exercise. This is particularly important for patients with HNC to help increase muscle strength and mitigate muscle atrophy 4 …”

Section: Discussionmentioning

confidence: 99%

“…This is particularly important for patients with HNC to help increase muscle strength and mitigate muscle atrophy. 4…”

Section: Pa Change Over Timementioning

confidence: 99%

“…3 Strength exercise helps increase muscle strength and mitigate muscle atrophy. 4 Despite the numerous benefits of PA, PA uptake was low in patients recently diagnosed with HNC 5 as well as HNC survivors. 6 Sammut and colleagues 7 investigated PA at both pre-and post-treatment in patients with HNC and identified that patients' average PA time was significantly reduced following treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Aerobic exercise promotes cardiovascular health and facilitates metabolic switching from states of catabolism to anabolism, and thus suppresses muscle atrophy 3 . Strength exercise helps increase muscle strength and mitigate muscle atrophy 4 . Despite the numerous benefits of PA, PA uptake was low in patients recently diagnosed with HNC 5 as well as HNC survivors 6 .…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer

et al. 2023

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Introduction The aim of this study was to explore the associations among physical activity (PA), inflammatory markers, and quality of life (QoL) from preradiotherapy to 1‐year postradiotherapy for patients with head and neck cancer (HNC). Methods This was an observational longitudinal study. Mixed‐effect models incorporating within‐subject correlation were used to examine the relationship among the three key variables. Results Aerobically active patients had significantly lower levels of sTNFR2 (but not other inflammatory markers) than aerobically inactive patients. Being aerobically active and lower inflammation were independently associated with better total QoL scores after adjusting covariates. The trend was similar for patients engaged in strength exercises. Conclusions Being aerobically active was associated with lower inflammation as represented by sTNFR2 but not with other inflammatory markers. Higher PA (aerobic and strength) and lower inflammation were linked to better QoL. More research is warranted to validate the association among PA, inflammation, and QoL.

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Section: Discussionmentioning

confidence: 99%

“…This is particularly important for patients with HNC to help increase muscle strength and mitigate muscle atrophy. 4…”

Section: Pa Change Over Timementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer

et al. 2023

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“…21,22 Rehabilitation with physical activity during and after treatment is an important aspect for cancer survivors, as sequelae are often identified. [23][24][25][26] Exercise is known to have positive effects on physical recovery (i.e. body composition, nutritional status, etc.…”

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confidence: 99%

Exercise-based rehabilitation on functionality and quality of life in head and neck cancer survivors. A systematic review and meta-analysis

Pérez

García

et al. 2023

Preprint

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Background Head and Neck Cancer (HNC) is a globally rare cancer that includes a variety of tumors affecting the upper aerodigestive tract. It presents with difficulty breathing or swallowing and is mainly treated with radiation therapy, chemotherapy, or surgery for tumors that have spread locally or throughout the body. Alternatively, exercise can be used during cancer treatment to improve function, including pain relief, increase range of motion and muscle strength, and reduce cancer-related fatigue, thereby enhancing quality of life. Although existing evidence suggests the adjunctive use of exercise in other cancer types, no previous studies have examined the effects of this therapy in HNC survivors. The aim of this meta-analysis was to quantify the effect of exercise-based rehabilitation on functionality and quality of life in HNC survivors who underwent surgery and/or chemoradiotherapy. A systematic review and meta-analysis were carried out following PRISMA statement and registered in PROSPERO (CRD42023390300). Search was performed in MEDLINE (PubMED), Cochrane Library, CINAHL and Web of Science (WOS) databases from inception to 31st December 2022 using the terms “cancer”, “head and neck neoplasms”, “exercise”, “rehabilitation”, “complications”, “muscle contraction”, “muscle stretching exercises” combining with booleans “AND”/ “OR”. PEDro scale, Cochrane Risk of Bias Tool and GRADE were used to assess methodological quality, risk of bias and grade of recommendation of included studies respectively. 18 studies (n = 1322) were finally included which 1039 (78.6%) were men and 283 (21.4%) were women. In patients underwent radio-chemotherapy, overall pain [SMD=-0.62 [-4.07, 2.83] CI 95%, Z = 0.35, P = 0.72] and OP [SMD=-0.07 [-0.62, 0.48] CI 95%, Z = 0.25, p = 0.81] were slightly reduced with exercise in comparison to controls. Besides, lower limb muscle strength [SMD=-0.10 [-1.52, 1.32] CI 95%, Z = 0.14, p = 0.89] and fatigue [SMD=-0.51 [-0.97, -0.057] CI 95%, Z = 2.15, p < 0.01] were also improved in those who receive radio-chemoradiation. In HNC survivors treated with neck dissection surgery, exercise was superior to controls in overall pain [SMD=-1.04 [-3.31, 1.23] CI 95%, Z = 0.90, p = 0.37] and, in mid-term, on shoulder pain SMD=-2.81 [-7.06, 1.43] CI 95%, Z = 1.76, p = 0.08]. No differences in quality of life were found at any of the follow-up periods. There is evidence of fair to good methodological quality, low to moderate risk of bias, and weak recommendation supporting the use of exercise-based rehabilitation to increase functionality. However, no evidence was found in favor of the use of this modality for improving the quality of life of HNC survivors who underwent chemoradiotherapy or surgery. The lack of standardization in the development of exercise programs, the diversity of randomized trials, and the heterogeneity of interventions and evaluations warrant further study.

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Exercise-based rehabilitation on functionality and quality of life in head and neck cancer survivors. A systematic review and meta-analysis

Pérez

García

et al. 2023

Sci Rep

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Head and Neck Cancer (HNC) is a globally rare cancer that includes a variety of tumors affecting the upper aerodigestive tract. It presents with difficulty breathing or swallowing and is mainly treated with radiation therapy, chemotherapy, or surgery for tumors that have spread locally or throughout the body. Alternatively, exercise can be used during cancer treatment to improve function, including pain relief, increase range of motion and muscle strength, and reduce cancer-related fatigue, thereby enhancing quality of life. Although existing evidence suggests the adjunctive use of exercise in other cancer types, no previous studies have examined the effects on HNC survivors. The aim of this meta-analysis was to quantify the effect of exercise-based rehabilitation on functionality and quality of life in HNC survivors who underwent surgery and/or chemoradiotherapy. A systematic review and meta-analysis were carried out following PRISMA statement and registered in PROSPERO (CRD42023390300). The search was performed in MEDLINE (PubMED), Cochrane Library, CINAHL and Web of Science (WOS) databases from inception to 31st December 2022 using the terms “cancer”, “head and neck neoplasms”, “exercise”, “rehabilitation”, “complications”, “muscle contraction”, “muscle stretching exercises” combining with booleans “AND”/“OR”. PEDro scale, Cochrane Risk of Bias Tool and GRADE were used to assess methodological quality, risk of bias and grade of recommendation of included studies respectively. 18 studies (n = 1322) were finally included which 1039 (78.6%) were men and 283 (21.4%) were women. In patients who underwent radio-chemotherapy, overall pain [SMD = − 0.62 [− 4.07, 2.83] CI 95%, Z = 0.35, p = 0.72] and OP [SMD = − 0.07 [− 0.62, 0.48] CI 95%, Z = 0.25, p = 0.81] were slightly reduced with exercise in comparison to controls. Besides, lower limb muscle strength [SMD = − 0.10 [− 1.52, 1.32] CI 95%, Z = 0.14, p = 0.89] and fatigue [SMD = − 0.51 [− 0.97, − 0.057] CI 95%, Z = 2.15, p < 0.01] were also improved in those who receive radio-chemoradiation. In HNC survivors treated with neck dissection surgery, exercise was superior to controls in overall pain [SMD = − 1.04 [− 3.31, 1.23] CI 95%, Z = 0.90, p = 0.37] and, in mid-term, on shoulder pain SMD = − 2.81 [− 7.06, 1.43] CI 95%, Z = 1.76, p = 0.08]. No differences in quality of life were found at any of the follow-up periods. There is evidence of fair to good methodological quality, low to moderate risk of bias, and weak recommendations supporting the use of exercise-based rehabilitation to increase functionality. However, no evidence was found in favor of the use of this modality for improving the quality of life of HNC survivors who underwent chemoradiotherapy or surgery.

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Effects of exercise training during concomitant chemoradiation therapy in head-and-neck cancer patients: A systematic review

Cited by 6 publications

References 9 publications

Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer

Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer

Exercise-based rehabilitation on functionality and quality of life in head and neck cancer survivors. A systematic review and meta-analysis

Exercise-based rehabilitation on functionality and quality of life in head and neck cancer survivors. A systematic review and meta-analysis

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