Effects of exercise training in hypoxia versus normoxia on fat-reducing in overweight and/or obese adults: A systematic review and meta-analysis of randomized clinical trials

Chen, Shuning; Sheng, Hao; Liu, Xinhong; Li, Qiaochu; Yao, Yingchi; Cai, Jiachen; Gao, Ye; Ma, Qirui; Shi, Yajun

doi:10.3389/fphys.2022.940749

Cited by 3 publications

(1 citation statement)

References 74 publications

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“…Compared with normoxia, the effects of hypoxia conditioning on both body fat (moderate) and BMI (large) were significant in the subgroup with longer exposure duration (≥ 60 min). Studies reported that sufficient daily hypoxia exposure time and prolonged duration of the training program significantly reduced body fat and body weight [ 72 , 73 ], which is in agreement with our findings. Therefore, exercise in moderate hypoxia combined with exposure duration of at least 60 min is recommended for improving body fat and BMI in middle-aged and older adults.…”

Section: Discussionsupporting

confidence: 93%

Effect of Hypoxia Conditioning on Body Composition in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis

He,

Qiang,

Liu

et al. 2023

Sports Med - Open

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Background The effects of hypoxia conditioning, which involves recurrent exposure to hypoxia combined with exercise training, on improving body composition in the ageing population have not been extensively investigated. Objective This meta-analysis aimed to determine if hypoxia conditioning, compared to similar training near sea level, maximizes body composition benefits in middle-aged and older adults. Methods A literature search of PubMed, EMBASE, Web of Science, Scopus and CNKI (China National Knowledge Infrastructure) databases (up to 27th November 2022) was performed, including the reference lists of relevant papers. Three independent reviewers extracted study characteristics and health outcome measures. Search results were limited to original studies of the effects of hypoxia conditioning on body composition in middle-aged and older adults. Results Twelve studies with a total of 335 participants were included. Hypoxia conditioning induced greater reductions in body mass index (MD = -0.92, 95%CI: -1.28 to -0.55, I2 = 0%, p < 0.00001) and body fat (SMD = -0.38, 95%CI: -0.68 to -0.07, I2 = 49%, p = 0.01) in middle-aged and older adults compared with normoxic conditioning. Hypoxia conditioning improved lean mass with this effect not being larger than equivalent normoxic interventions in either middle-aged or older adults (SMD = 0.07, 95%CI -0.12 to 0.25, I2 = 0%, p = 0.48). Subgroup analysis showed that exercise in moderate hypoxia (FiO2 > 15%) had larger effects than more severe hypoxia (FiO2 ≤ 15%) for improving body mass index in middle-aged and older adults. Hypoxia exposure of at least 60 min per session resulted in larger benefits for both body mass index and body fat. Conclusion Hypoxia conditioning, compared to equivalent training in normoxia, induced greater body fat and body mass index improvements in middle-aged and older adults. Adding hypoxia exposure to exercise interventions is a viable therapeutic solution to effectively manage body composition in ageing population.

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Section: Discussionsupporting

confidence: 93%

Effect of Hypoxia Conditioning on Body Composition in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis

He,

Qiang,

Liu

et al. 2023

Sports Med - Open

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Gut Microbiota Regulation by Acupuncture and Moxibustion: A Systematic Review and Meta-Analysis

Bae,

Jang,

Kim

et al. 2024

Am. J. Chin. Med.

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There have been numerous studies investigating the impact of acupuncture and/or moxibustion on the gut microbiota, but the results have been inconclusive. Therefore, we conducted a systematic review and meta-analysis that included both preclinical and clinical studies to assess the current evidence regarding the effects of acupuncture on gut microbiota changes. We collected relevant studies from EMBASE and PubMed, collected outcomes including diversity and relative abundance measures of the gut microbiome, and the summarized effect estimates were calculated using the ratio of means (ROM) with 95% confidence intervals. Our analysis identified three clinical studies and 20 preclinical studies, encompassing various diseases and models, including colitis and obesity. The pooled results indicated no significant difference in alpha diversity changes between treatment groups and controls, except for the Simpson index measure, which was significantly higher in the treatment groups. Additionally, the pooled results showed an increase in the Firmicutes and a decrease in the Bacteroidetes in the treatment groups, along with increases in the Lactobacillus and Ruminococcus genera. These findings suggest acupuncture treatment can target the modification of specific phyla and genera of gut microbiota. However, it is important to note that the effects of acupuncture on the gut microbiome are heterogeneous across studies, particularly in different disease models.

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Intermittent normobaric hypoxia alters substrate partitioning and muscle oxygenation in individuals with obesity: implications for fat burning

Costalat,

Lemaitre,

Ramos

et al. 2024

American Journal of Physiology-Regulatory, Integrative and Comp

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This single-blind, crossover study aimed to measure and evaluate the short-term metabolic responses to continuous and intermittent hypoxic patterns in individuals with obesity. Indirect calorimetry was used to quantify changes in resting metabolic rate (RMR), carbohydrate (CHOox, %CHO) and fat oxidation (FATox, %FAT) in nine individuals with obesity pre- and post-: (i) breathing normoxic air [normoxic sham control (NS-control)]; (ii) breathing continuous hypoxia (CH); or (iii) breathing intermittent hypoxia (IH). A mean peripheral oxygen saturation (SpO2) of 80-85% was achieved over a total of 45 minutes of hypoxia. Throughout each intervention pulmonary gas exchanges - oxygen consumption ( ), carbon dioxide production ( - and deoxyhaemoglobin concentration ( [HHb]) in the vastus lateralis were measured. Both RMR and CHOox measured pre- and post-interventions were unchanged following each treatment: NS-control; CH; or IH (all p > 0.05). Conversely, a significant increase in FATox was evident between pre- and post-IH (+44%, p = 0.048). While the mean [HHb] values significantly increased during both IH and CH ( p<0.05), the greatest zenith of [HHb] was achieved in IH compared to CH ( p = 0.002). Furthermore, there was a positive correlation between ∆[HHb] and the shift in FATox measured pre- and post-intervention. It is suggested that during IH the increased bouts of muscle hypoxia, revealed by elevated ∆[HHb], coupled with cyclic periods of excess post-hypoxia oxygen consumption (EPHOC, inherent to the intermittent pattern) played a significant role in driving the increase in FATox post-IH.

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Effects of exercise training in hypoxia versus normoxia on fat-reducing in overweight and/or obese adults: A systematic review and meta-analysis of randomized clinical trials

Cited by 3 publications

References 74 publications

Effect of Hypoxia Conditioning on Body Composition in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis

Effect of Hypoxia Conditioning on Body Composition in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis

Gut Microbiota Regulation by Acupuncture and Moxibustion: A Systematic Review and Meta-Analysis

Intermittent normobaric hypoxia alters substrate partitioning and muscle oxygenation in individuals with obesity: implications for fat burning

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