Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea

Ueno-Pardi, Linda M; Duran, Fábio Luís de Souza; Matheus, None Lorena Andrade; Rodrigues, Amanda G.; Barbosa, E. R.; Cunha, Paulo Jannuzzi; Carneiro, Camila de Godoi; Costa, Naomi Antunes da; Ono, Carla Rachel; Buchpiguel, Carlos Alberto; Negräo, Carlos Eduardo; Lorenzi‐Filho, Geraldo; Busatto-Filho, Geraldo

doi:10.1038/s41598-022-13115-2

Cited by 12 publications

(3 citation statements)

References 54 publications

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“…Polysomnography was performed using standardized techniques, with a standard staging system for the sleep stages used as described in previous studies. 18,19 The AHI was determined by the sum of apneas and hypopneas per hour of sleep. We used a conservative AHI cutoff of !…”

Section: Sleep Studymentioning

confidence: 99%

“…The procedures and descriptions of the cognitive tests used in the present study have been published elsewhere. 19 The cognitive tests were performed on the same day as the sleep studies. Attention and executive function were evaluated using the Trail Making Test-Parts A and B, Forward Digits test, Backward Digits test, Digit Symbol test, Stroop Color Word Test (SCWT), and Frontal Assessment Battery.…”

Section: Cognitive Functionmentioning

confidence: 99%

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APOE Polymorphism, Obstructive Sleep Apnea, and Cognitive Function

Gara,

Goya,

Ferreira-Silva

et al. 2024

Sleep Sci

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Objective Obstructive sleep apnea (OSA) is associated with the apolipoprotein E ε4 polymorphic allele (APOE ε4) and with worse cognitive function. However, the influence of APOE ε4 on cognitive function in patients with moderate-to-severe OSA is controversial. The present study evaluated the influence of APOE ε4 polymorphism and cognitive function in sedentary OSA patients with no other major comorbidities. Materials and Methods In total, 55 middle-aged patients underwent conventional nocturnal polysomnography, APOE ε4 polymorphism genotyping, cognitive evaluation (attention, inhibitory control, frontal functions, processing speed, and episodic memory), and they filled out the International Physical Activity Questionnaire. Results Overall, 13 patients had no or mild OSA, and 42 had moderate-to-severe OSA (apnea-hypopnea index [AHI] ≥ 15 events/h of sleep) and APOE ε4 was present in 7.7% and 21.4% of the patients in each group respectively. Among patients with moderate-to-severe OSA, the sleep parameters were similar in the groups of APOE ε4 carriers and noncarriers. Compared with patients with no or mild OSA, the cognitive parameters were worse for processing speed (Digit Symbol Test) and attention (Stroop Color Word Test, SCWT-Part 2) among the patients with moderate-to-severe OSA. The difference was present even after the exclusion of APOE ε4 carriers. Among patients with moderate-to-severe OSA, APOE ε4 carriers presented worse episodic memory, evaluated through the Rey Auditory Verbal Learning Test, than APOE ε4 noncarriers. Conclusion Moderate-to-severe OSA is associated with poor cognitive function that is further impaired by the presence of APOE ε4 polymorphism.

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Section: Sleep Studymentioning

confidence: 99%

Section: Cognitive Functionmentioning

confidence: 99%

APOE Polymorphism, Obstructive Sleep Apnea, and Cognitive Function

Gara,

Goya,

Ferreira-Silva

et al. 2024

Sleep Sci

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“…A number of randomised studies have reported less consistent results. A supervised cycle ergometry programme in exercise-naïve OSA patients resulted in an improvement in AHI, arousal index and overnight desaturation index when compared to controls ( 33 ). A study comparing a 12-week supervised aerobic exercise class with stretching-control treatment demonstrated improved AHI and overnight desaturation index in the exercise group, but non-significant improvements in total sleep time, wake after sleep onset and sleep efficiency ( 34 ).…”

Section: Osamentioning

confidence: 99%

Sleep disorders and exercise: a mini-review

Shah,

Bennett,

Hassan

et al. 2023

J Thorac Dis

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Sleep disturbance in a growing problem in the general population. As the prevalence of sleep disturbance rises, interest in treatment modalities including non-pharmaceutical interventions also grows. One of these potential modalities is exercise therapy. In individuals without sleep disorders, exercise appears to be beneficial in improving sleep architecture without any impact of the timing of exercise in relation to onset of sleep. The mechanisms for this are largely unknown but may be due to a combination of the effects of exercise on body temperature, autonomic control, endocrine and metabolic function. In obstructive sleep apnoea (OSA), supervised exercise therapy appears to have positive impact on daytime sleepiness with an unknown impact on sleep quality. The effect of exercise on central sleep apnoea (CSA) will be difficult to ascertain due to the low prevalence of this condition. In primary sleep disorders such as insomnia, narcolepsy and restless syndrome exercise may be useful in improving sleep architecture but the quality of the evidence supporting this remains low. In addition, the timing of exercise in relation to sleep onset remains under investigated. In individuals with circadian rhythm disorders, evening exercise appears to delay sleep onset. In shift-pattern workers, individuals with increased cardiorespiratory fitness report better sleep quality, suggesting exercise may be protective in this important population. To allow high quality evidence-based recommendations to be made about the value of exercise in individuals with sleep disorders, there is a significant need for large prospective studies with objective and subjective sleep quality as a primary outcome.

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