Effects of Exercise Training on Airway Hyperreactivity in Asthma: A Systematic Review and Meta-Analysis

Eichenberger, Philipp A.; Diener, Stephanie N.; Kofmehl, Reto; Spengler, Christina M.

doi:10.1007/s40279-013-0077-2

Cited by 157 publications

(129 citation statements)

References 71 publications

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“…Physical training in obese and nonobese people has been associated with asthma outcomes such as AHR, FEV 1 , symptoms, and quality of life. 27,28 It remains possible, therefore, that the eff ects observed in the present study on these outcomes resulted from exercise rather than from weight loss per se. Further research in this area would benefi t from isolating the dietary and exercise components of a weight reduction program in the evaluation design.…”

Section: Discussionmentioning

confidence: 76%

Effects of Weight Loss on Airway Responsiveness in Obese Adults With Asthma

Pakhalé

Baron

Dent

et al. 2015

Chest

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Section: Discussionmentioning

confidence: 76%

Effects of Weight Loss on Airway Responsiveness in Obese Adults With Asthma

Pakhalé

Baron

Dent

et al. 2015

Chest

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“…A total of 17 studies (n ¼ 599) were reviewed and exercise training showed a significant improvement in days without asthma symptoms, FEV1, QoL, and exercise capacity. The authors concluded that physical activity should be recommended as a supplementary therapy to medication [70].…”

Section: Lifestylementioning

confidence: 99%

Complementary and alternative medicine in pulmonology

Mark

Chung

2015

Current Opinion in Pediatrics

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“…A consistent pathological feature is the presence of bronchial hyperresponsiveness related to the underlying airway inflammation [1]. In recent decades, regular exercise training in asthmatics was shown to result in cardiopulmonary adaptations similar to healthy subjects and, more importantly, to a reduction in airway inflammation and bronchial hyperresponsiveness in some studies [2, 3]. However, the mechanisms related to the airway-specific improvements are not yet fully established.…”

Section: Introductionmentioning

confidence: 99%

Similar Airway Function after Volitional Hyperpnea in Mild-Moderate Asthmatics and Healthy Controls

et al. 2019

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Background: The beneficial effects of exercise training for asthmatics might relate to repetitive airway stretching. Thus, a training with more pronounced airway stretch using isolated, volitional hyperpnea (HYP) might be similarly or more effective. However, in healthy subjects, a bout of HYP training is known to cause an acute FEV₁ decline. Objective: The aim of the present study was therefore to test whether these changes are more pronounced in asthmatics, possibly putting them at risk with HYP training. Methods: Nine subjects with mild-moderate asthma (confirmed by mannitol challenge) and 11 healthy subjects performed six 5-min bouts (with 6-min breaks; HYP₁) and one 30-min bout (HYP₂) of normocapnic HYP at 60% of maximal voluntary ventilation using warm and humid air. FEV₁ and airway resistance (R5) were measured before, in breaks (HYP₁), and immediately after HYP, and during 60 min of recovery. Results: In both groups, a significant and similar decrease in FEV₁ during HYP₁ (asthmatics: –3 ± 3%; healthy subjects: –2 ± 3%), after HYP₁ (asthmatics: –2 ± 5%; healthy subjects: –1 ± 4%), and after HYP₂ (asthmatics: –4 ± 5%; healthy subjects: –3 ± 3%), and an increase in R5 during and after both HYPs were observed. Maximal changes in FEV₁ and R5 did not correlate with baseline lung function or responsiveness to mannitol. Conclusions: A bout of HYP does not lead to relevant bronchoconstriction and the observed changes in lung function and airway resistance are neither of the magnitude of clinical relevance, nor do they differ from responses in healthy individuals. Thus, HYP training can safely be tested as an airway-specific exercise training alternative (or add-on) modality to regular aerobic exercise training.

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Effects of Exercise Training on Airway Hyperreactivity in Asthma: A Systematic Review and Meta-Analysis

Cited by 157 publications

References 71 publications

Effects of Weight Loss on Airway Responsiveness in Obese Adults With Asthma

Effects of Weight Loss on Airway Responsiveness in Obese Adults With Asthma

Complementary and alternative medicine in pulmonology

Similar Airway Function after Volitional Hyperpnea in Mild-Moderate Asthmatics and Healthy Controls

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