Effects of Exogenous Adenosine in a Patient with Transplanted Heart. Evidence for Adenosine as a Messenger in Angina Pectoris

Lagerqvist, Bo; Sylvén, Christer; Helmius, Gunnar; Waldenström, Anders

doi:10.3109/03009739009178582

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…'2 Further evidence is provided by the fact that when adenosine was given intravenously to patients with heart transplants the pain threshold was greatly increased. 25 The difference in sensitivity between the group with ischaemic heart disease and healthy volunteers has not been described before. This could reflect a true difference or it could be the result of the experimental design.…”

Section: Discussionmentioning

confidence: 90%

Lower threshold for adenosine-induced chest pain in patients with angina and normal coronary angiograms

Lagerqvist¹,

Sylvén²,

Waldenström³

1992

Heart

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Objective-To investigate whether patients with angina-like chest pain and normal coronary angiograms are more sensitive to adenosine as an inducer of chest pain.Design-Increasing doses of adenosine were given in a single blind study as intravenous bolus injections. Chest pain and the electrocardiographic findings were noted.Patients-Eight patients with anginalike chest pain but no coronary stenoses (group A), nine patients with angina and coronary stenoses (group B), and 16 healthy volunteers (group C).Results-In the absence of ischaemic signs on the electrocardiogram adenosine provoked angina-like pain in all patients in groups A and B. The pain was located in the chest, and its quality and location were described as being no different from the patient's habitual angina. In group C, 14 of 16 subjects reported chest pain. The lowest dose resulting in chest pain was lower in group A (09 (06) mg) than in group B (3-1 (1-5) mg) (p < 0005) and in group C (6X2 (3 7) mg) (p < 0005). The maximum tolerable dose was lower in group A (4 7 (2X1) mg) than in group B (9X2 (3 8) mg) (p < 005) and in group C (12-0 (4-1) mg) (p < 0005).Conclusions-Patients with anginalike chest pain and normal coronary angiograms have a low pain threshold and low tolerance to pain induced by adenosine. (Br Heart J 1992;68:282-5)

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Section: Discussionmentioning

confidence: 90%

Lower threshold for adenosine-induced chest pain in patients with angina and normal coronary angiograms

Lagerqvist¹,

Sylvén²,

Waldenström³

1992

Heart

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“…Adenosine was claimed to be a messenger between myocardial ischaemia and angina pectoris in a patient with a transplanted heart [800]. Intracoronary adenosine administration provoked anginal pain and aminophylline, a P1R antagonist, reduced both adenosine and exercise-induced chest pain [801].…”

Section: Anginamentioning

confidence: 99%

Cardiac purinergic signalling in health and disease

Burnstock

Pelleg

2014

Purinergic Signalling

120

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This review is a historical account about purinergic signalling in the heart, for readers to see how ideas and understanding have changed as new experimental results were published. Initially, the focus is on the nervous control of the heart by ATP as a cotransmitter in sympathetic, parasympathetic, and sensory nerves, as well as in intracardiac neurons. Control of the heart by centers in the brain and vagal cardiovascular reflexes involving purines are also discussed. The actions of adenine nucleotides and nucleosides on cardiomyocytes, atrioventricular and sinoatrial nodes, cardiac fibroblasts, and coronary blood vessels are described. Cardiac release and degradation of ATP are also described. Finally, the involvement of purinergic signalling and its therapeutic potential in cardiac pathophysiology is reviewed, including acute and chronic heart failure, ischemia, infarction, arrhythmias, cardiomyopathy, syncope, hypertrophy, coronary artery disease, angina, diabetic cardiomyopathy, as well as heart transplantation and coronary bypass grafts.

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Adenosine receptors in the cardiovascular system

Olsson

1996

Drug Dev. Res.

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Effects of Exogenous Adenosine in a Patient with Transplanted Heart. Evidence for Adenosine as a Messenger in Angina Pectoris

Cited by 6 publications

References 10 publications

Lower threshold for adenosine-induced chest pain in patients with angina and normal coronary angiograms

Lower threshold for adenosine-induced chest pain in patients with angina and normal coronary angiograms

Cardiac purinergic signalling in health and disease

Adenosine receptors in the cardiovascular system

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