Effects of exogenous interferon in cytomegalovirus infections complicating bone marrow transplantation

O’Reilly, Richard J.; Everson, Lloyd K.; Emödi, G.; Smithwick, Elizabeth M.; Grimes, Elena; Pahwa, Savita; Pahwa, R.; Schwartz, Stanley A.; Armstrong, Donald; Siegal, Frederick P.; Gupta, Sudhir; Dupont, Bo; Good, Robert A.

doi:10.1016/0090-1229(76)90060-x

Cited by 29 publications

(7 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general these haematological changes were not precluding continuation of treatment. Lack of bone marrow engraftment, as evidence for myelosuppression, was not seen in a study in which leukocyte interferon was administered to bone-marrow transplant patients in order to prevent viral infections (55). A decrease in the white blood cell count from 5000 to 3000 was found in patients given a single injection of 1.2 to 3.0 × 106 units of lymphoblastoid interferon (60) ; this leukopenia was maximal 12 hours post injection and was not yet completely restored to normal after 48 hours.…”

Section: Cytostatic E//ectsmentioning

confidence: 88%

Interferon therapy: Pharmacokinetic and pharmacological aspects

Billiau

1981

Archives of Virology

View full text Add to dashboard Cite

Section: Cytostatic E//ectsmentioning

confidence: 88%

Interferon therapy: Pharmacokinetic and pharmacological aspects

Billiau

1981

Archives of Virology

View full text Add to dashboard Cite

“…Preliminary studies with cytomegalovirus-infected infants have indicated that human leukocyte interferon treatment causes a decrease in viruria, suggesting that interferon may be controlling the replication of the virus [10,54,175], Interferon has also been shown to have an antiviral effect against varicella zoster. Preliminary studies suggested that interferon administration could be safely tolerated by cancer patients with varicella zoster infections [67,121].…”

Section: F In Vivo Inhibition Of Herpesvirus Infections By Interferonmentioning

confidence: 99%

The role of interferon in viral infections

Sonnenfeld

Merigan

1979

Springer Semin Immunopathol

View full text Add to dashboard Cite

Interferon, a product of mammalian tissues, was originally described as an antiviral agent over twenty years ago. Only in the past few years has evidence started to accumulate that interferon actually played a role in vivo in natural virus infections.Initially, evidence was accumulated showing that interferon could inhibit the replication of many viruses in vitro. The interferon, through induction of a second antiviral protein, could inhibit in vitro viral transcription or translation. Later, indirect evidence for an effect of interferon on in vivo viral infections was obtained by showing that (a) a temporal relationship existed between the appearance of interferon in viral infections and the progress of the infection and (b) treatment of virally infected animals with exogenous interferon or interferon inducer often resulted in less severe infections.The most recent and direct evidence for a role for interferon in natural viral infections involves the use of an anti-interferon globulin. In several cases, injection of the anti-interferon globulin into animals infected with a wide variety of viruses resulted in a severely altered course of infection. These studies suggest that interferon is directly involved in the progress of viral infections. The involvement of the interferon in the viral infections could be a direct effect of the interferon on viral replication, or an interaction of the interferon with other host defenses, such as the immune system.

show abstract

“…IFN of all types reduces CMV early and late antigen induction in fibro blasts in vitro [our unpublished data]. When IFN has been administered in vivo to pa tients with acute CMV infections, the results have been variable [38][39][40][41], There are indica tions that it may be useful for prophylaxis, delaying CMV infection in renal or bone marrow transplant recipients [42]. Similarly, IFN diminished EBV excretion in renal transplant recipients when given prophylactically [43].…”

Section: Discussionmentioning

confidence: 99%

Interferon Induction in Human Leukocytes after in vitro Exposure to Cytomegalovirus or Epstein-Barr Virus

Einhorn

Wahrén

1985

Intervirology

View full text Add to dashboard Cite

Interferon (IFN) was produced after exposure of human mononuclear leukocytes and bone marrow cells to infectious or noninfectious cytomegalovirus (CMV) in vitro. The IFN was generated mainly by non-B lymphocytes. Both α- and γ-type IFN could be demonstrated. CMV antigens were usually not demonstrable in CMV-exposed leukocytes. Addition of anti-IFN antibodies did not induce CMV antigens. Thus, it seems that the endogenous production of IFN is not responsible for the difficulties in demonstrating CMV antigens after in vitro exposure of normal human leukocytes to CMV. Addition of Epstein-Barr virus (EBV) B95–8 to leukocytes induced the production of α-type IFN. Exogenously added IFN reduced the induction of EBV-determined nuclear antigen (EBNA). However, the presence of anti-IFN antibodies in EBV-infected cultures did not increase the number of EBNA-positive cells.

show abstract

Effects of exogenous interferon in cytomegalovirus infections complicating bone marrow transplantation

Cited by 29 publications

References 18 publications

Interferon therapy: Pharmacokinetic and pharmacological aspects

Interferon therapy: Pharmacokinetic and pharmacological aspects

The role of interferon in viral infections

Interferon Induction in Human Leukocytes after in vitro Exposure to Cytomegalovirus or Epstein-Barr Virus

Contact Info

Product

Resources

About