Effects of exogenous melatonin on clinical and pathological features of a human thyroglobulin-induced experimental autoimmune thyroiditis mouse model

Lin, Jiunn Diann; Fang, Wen; Tang, Kuo‐Tung; Cheng, Chao

doi:10.1038/s41598-019-42442-0

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…A third membrane-bound MTNbinding site, the MT3 receptor, was theorized as a biological target of MTN and was found to, in fact, act as the cytosolic enzyme, quinone reductase II (NQO2) 12 . Some authors have reported in their genetic study that the single-nucleotide polymorphism of MTN receptor type 1A, MTNR1A, coding the MT1 protein, was associated with a sensitivity to Graves' disease and thyroid autoantibody formation, which supports the impression, that MTN can influence the development of autoimmune thyroid disease in thyroidology 13,14 . The thyroid gland is characterized by a high level of oxidative stress, and the use of pro-oxidants can lead to miscellaneous damage and diseases of this delicate papillon gland.…”

mentioning

confidence: 78%

Melatonin, menopause, and thyroid function in gynecologic endocrinology: what is the role?

Soares Junior,

Detanac,

Sengul

et al. 2024

Rev. Assoc. Med. Bras.

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Melatonin (MTN), a neurohormone primarily synthesized and secreted mainly by the pine cone-shaped gland of the cerebrum, named as the conarium or epiphysis cerebri, from amino acid tryptophan, was first isolated from the bovine pineal gland by Lerner et al 1 . However, the 17th-century philosopher René Descartes hypothesized that the pineal gland of the brain, which remains poorly understood to date, represents the location of the homo sapiens soul; paleontologists described it as an ancestral "third eye"; and modern psychology declares perception beyond physical visual function 2,3 . This chemical messenger, per se, ensures high precision in the reconnoitering of the night period, is an endocrine marker for darkness, and participates in the regulation of circadian rhythm and the sleep-wake cycle. Of note, MTN can be produced by other organs, such as the brain, lungs, gastrointestinal tract, liver, thyroid, and reproductive and immune systems, and is present in mucus, saliva, breast milk, urine, sperm, amniotic fluid, Graafian follicle, etc. 1,4-9 . As such, various studies have shown that MTN affects many functions in the body and acts on different tissues, and some of its properties include significant antioxidant, anti-inflammatory, antiproliferative, and immunomodulatory capacity. MTN, per se, can directly neutralize toxic free radicals more effectively, suppresses chronic oxidative stress, has a significant impact on reproductive cells, enhances the quality of sperm and oocytes, has oncostatic and antitumoral cytoprotective effects 10,11 , alleviates some of the undesirable toxic effects of radiotherapy and chemotherapy by increasing the tolerance of healthy tissues, compared to other antioxidants, by stimulating responses to DNA damage. To this

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mentioning

confidence: 78%

Melatonin, menopause, and thyroid function in gynecologic endocrinology: what is the role?

Soares Junior,

Detanac,

Sengul

et al. 2024

Rev. Assoc. Med. Bras.

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“…Those tissues were not collected for the KRT1 mRNA analysis in the current study, and the main source of elevated serum KRT1 in GD remains unclear. It is our future plan to gather mouse serum, skin, thyroid, and peripheral white blood cells at the same time, to quantify KRT1 transcripts of these tissues using the mouse thyroiditis model built by our laboratory, to elucidate the possible origin of elevated serum KRT1 stimulated by the TH [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Associations of serum keratin 1 with thyroid function and immunity in Graves’ disease

Cheng,

Fang,

Lin

2023

PLoS ONE

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Background Autoimmune thyroid disease (AITD) can cause enormous health burdens; however, trustworthy biomarkers in identifying the onset and progression of AITD are limited. In this study, we attempted to discover new potential serum biomarkers to discriminate AITD using mass spectrometry (MS). Methods In the biomarker study cohort, 20 patients with Graves’ disease (GD), 20 patients with Hashimoto’s thyroiditis (HT), and 20 healthy controls were enrolled for a liquid chromatographic-tandem MS assessment. A novel biomarker, keratin 1 (KRT1), was selected for further evaluation in the validation cohort, including 125 patients with GD, 34 patients with HT, and 77 controls. Relationships of serum KRT1 with AITD-related immunomodulatory cytokines were also analyzed using enzyme-linked immunosorbent assays (ELISAs). Results In the MS analysis, KRT1 was the single marker overexpressed in GD, while it was underexpressed in HT. In the ELISA analysis of the validation cohort, KRT1 was consistently upregulated in GD, while it was not downregulated in HT. There were significant associations of KRT1 levels with thyroid function in GD, AITD, and overall subjects. Additionally, a significant association of KRT1 levels with thyroid-stimulating hormone receptor antibody (TSHRAb) levels was observed. Moreover, there were significant associations of KRT1 with osteopontin (OPN) and B-cell activating factor (BAFF) levels in GD. Conclusions Serum KRT1 levels were upregulated in GD and were associated with thyroid function and TSHRAb levels. Moreover, KRT1 was correlated with the BAFF and OPN levels in GD patients. Further molecular-based research to elucidate the role of KRT1 in the pathogenesis of AITD is needed.

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“…In an experimental model of hypothyroidism, it has been demonstrated that melatonin could increase the level of thyroid hormones via regulating the neuroendocrine axis and upregulation of TSH, pointing out that exogenous melatonin differentially modulates the MT1 and MT2 receptor protein expression in the pituitary and thyroid gland (64). Additionally, it has been shown that melatonin can increase plasma thyroid hormone levels and enhance thyrocyte destruction and the T-cell proliferation capacity in the autoimmune thyroiditis mouse model (65). There is very limited evidence for the effects of supplemental melatonin on human thyroid function.…”

Section: Melatoninmentioning

confidence: 99%

Dietary factors and thyroid dysfunction

Đuričić¹,

Todorović²,

Dabetić³

et al. 2022

Arhiv za farmaciju

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Besides iodine deficiency, autoimmune Hashimoto thyroiditis is the leading cause of hypothyroidism globally, characterized by the increased titer of thyroid autoantibodies and destruction of thyroid cells. Graves' disease is the most common etiology of hyperthyroidism worldwide. Patients with thyroid dysfunction often require dietary modifications. Popular interventions include supplementation with certain vitamins and minerals, as well as trace elements such as iodine and selenium. The intake of food containing goitrogens should be limited. Goitrogens are substances of plant origin that interfere with the production of thyroid hormones, increasing the risk for goiter and hypothyroidism. The primary dietary sources of goitrogens are cruciferous vegetables, soy products, starchy plants, and some fruits. Beyond essential nutrients, there has been an increasing interest in using specific nutraceuticals, including myoinositol, Lcarnitine, melatonin, and resveratrol, as potential preventive and therapeutic agents in thyroid diseases. Even though current evidence promotes some beneficial outcomes of these nutraceuticals, further investigations are needed to clarify dose-dependent effects, duration of supplementation, combination in different clinical settings, and the exact mechanism of their action in thyroid disorders.

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Effects of exogenous melatonin on clinical and pathological features of a human thyroglobulin-induced experimental autoimmune thyroiditis mouse model

Cited by 7 publications

References 31 publications

Melatonin, menopause, and thyroid function in gynecologic endocrinology: what is the role?

Melatonin, menopause, and thyroid function in gynecologic endocrinology: what is the role?

Associations of serum keratin 1 with thyroid function and immunity in Graves’ disease

Dietary factors and thyroid dysfunction

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