Effects of exogenous oxytocin administration on non-social executive function in humans: A preregistered systematic review and meta-analysis protocol

Glaser, Bernt; Sartorius, Alina M.; Audunsdottir, Kristin; Nærland, Terje; Andreassen, Ole A.; Westlye, Lars T.; Quintana, Daniel

doi:10.31219/osf.io/8fzdy

Cited by 2 publications

(3 citation statements)

References 38 publications

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“…As stated in our pre-registered analysis plan [76], we anticipated that some eligible studies would have collected more than one type of outcome to measure the effect of oxytocin on non-social executive function performance. To address the risk of inflated effect size due to dependent outcomes, we performed multilevel meta-analysis using the restricted maximum-likelihood estimator [77] with 20 outcomes from 13 studies.…”

Section: Meta-analysismentioning

confidence: 99%

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Effects of oxytocin administration on non-social executive functions in humans: A preregistered systematic review and meta-analysis

Glaser¹,

Sartorius²,

Audunsdottir³

et al. 2023

Preprint

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Oxytocin has received considerable research attention for its role in affiliative behaviors, particularly regarding its pro-social effects. However, more recent evidence has pointed to a potentially broader role of oxytocin signaling, which includes the moderation of non-social cognition. To evaluate the evidence for non-social effects of oxytocin administration, we performed a systematic review and meta-analysis with 19 effect estimates from 12 studies. We found no overall significant effect of oxytocin administration on non-social executive functions (p = 0.21; Hedges’ g = 0.10). However, effect sizes across sub-categories of executive function varied, where the effect of oxytocin administration was the largest for cognitive flexibility (Hedges’ g = 0.27). Publication bias was assessed using Robust Bayesian Meta-Analysis, which yielded anecdotal support for the absence of publication bias (BFPB = 0.97). Altogether, our data analysis suggests that oxytocin’s effects may extend beyond social cognitive processing as data synthesis provided evidence supporting a role in non-social cognitive flexibility. The data and analysis output from this meta-analysis are provided via a point-and-click web application.

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Section: Meta-analysismentioning

confidence: 99%

“…Pre-registration for this review is available on PROSPERO (ID: CRD42022308149). Protocol with detailed plan for data collection and analysis was published as a preprint on Open Science Framework [76].…”

Section: Conflict Of Interestmentioning

confidence: 99%

Effects of oxytocin administration on non-social executive functions in humans: A preregistered systematic review and meta-analysis

Glaser¹,

Sartorius²,

Audunsdottir³

et al. 2023

Preprint

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“…The ESDist package is then downloaded from Github and loaded into the user's R environment.The package contains two example data files: ot_dat_raw and ot_dat. The data file ot_dat_raw contains 616 effect sizes from 15 meta-analyses on oxytocin intervention studies (Bakermans-Kranenburg & van IJzendoorn, 2013;Chen et al, 2021;Huang et al, 2021;Kang et al, 2022;Keech et al., A TUTORIAL FOR CALCULATING FIELD-SPECIFIC EFFECT SIZE DISTRIBUTIONS 11 2018;…”

mentioning

confidence: 99%

A tutorial for calculating field-specific effect size distributions

Glaser,

Kang,

Audunsdottir

et al. 2023

Preprint

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Effect sizes are useful for understanding the magnitude of study results and for planning new studies using power analysis. But despite their wide usage, effect sizes are often misinterpreted. This is mostly due to an over-reliance on general effect size benchmarks that were never intended for broad application across a range of research fields. Inaccurate effect size interpretations can consequently lead to incorrect conclusions regarding the magnitude of study results, as well as incorrect sample size estimates, which can increase the likelihood of false positive results. The aim of this article is to introduce the ESDist R package, which is designed to calculate empirically derived effect size benchmarks or a range of reliably detectable empirical effect sizes for a specific research question or field of interest. This package can be used on data that can be easily extracted from pre-existing meta-analyses to help researchers more accurately plan new studies or to better understand how an individual study might relate to other studies in their field of interest. ESDist includes a set of features that make it easy to use in a priori power analysis. Moreover, the package contains a means to estimate effect size benchmarks that account for publication bias. A companion screencast video is also provided to demonstrate the use of the ESDist package.

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Effects of exogenous oxytocin administration on non-social executive function in humans: A preregistered systematic review and meta-analysis protocol

Cited by 2 publications

References 38 publications

Effects of oxytocin administration on non-social executive functions in humans: A preregistered systematic review and meta-analysis

Effects of oxytocin administration on non-social executive functions in humans: A preregistered systematic review and meta-analysis

A tutorial for calculating field-specific effect size distributions

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