Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain

Thakur, Pratibha; Shrivastava, Renu; Shrivastava, Vinoy K.

doi:10.1016/j.ibror.2019.04.001

Cited by 7 publications

(4 citation statements)

References 56 publications

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“…For example, infusion of OT into the nucleus accumbens was shown to increase glutamate levels in that region (Weber et al, 2018), without producing enhancements in NAS DA (Lee et al, 2019). OT has also been shown to increase GABA in multiple brain regions, including the hypothalamus, via a mechanism that is sensitive to atosiban (Thakur et al, 2019). Microdialysis studies on pre‐frontal cortex and dorsal hippocampus showed OT did not alter baseline glutamate, but did blunt methamphetamine‐induced increases in glutamate, while OT increased baseline GABA and blunted methamphetamine‐induced decreases in the hippocampus (Qi et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Oxytocin receptors mediate oxytocin potentiation of methylphenidate‐induced stimulation of accumbens dopamine in rats

Hersey

Bacon

Bailey

et al. 2022

Journal of Neurochemistry

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While the illicit use and misuse of stimulants like cocaine and methylphenidate (MP) has increased, there remains no FDA-approved treatments for psychostimulant use disorders (PSUD). Oxytocin (OT) has shown promise as a potential pharmacotherapy for PSUD. Dopamine (DA) neurotransmission plays a significant role in PSUD. We have recently shown that OT blunts the reinforcing effects of MP but, surprisingly, enhanced MP-induced stimulation of DA levels. Such effects have been suggested as a result of activation of OT receptors or, alternatively, could be mediated by direct actions of OT on MP blockade of the DA transporter. Here, we employed fast scan cyclic voltammetry (FSCV) to investigate the effects of systemic OT on MP-induced changes in the dynamics of DA, phasic release and uptake, in the nucleus accumbens shell (NAS) of Sprague-Dawley rats. We also tested the systemic effects of an antagonist of OT receptors, atosiban, to counteract the OT enhancement of dopaminergic effects of MP under microdialysis procedures in the NAS in rats. Administration of OT alone (2 mg/kg; i.p.) did not significantly modify evoked NAS DA dynamics measured by FSCV, and when administered 10 min before MP (0.1, 0.3, 1.0 mg/kg; i.v.), OT did not potentiate MP-induced increases in phasic DA release and did not alter DA clearance rate, suggesting no direct interactions of OT with the MP-induced blockade of DA uptake. Also, OT alone did not elicit significant changes in tonic, extracellular NAS DA levels measured by microdialysis. However, consistent with previous studies, we observed that OT pretreatments (2 mg/kg; i.p.) potentiated MP-induced (0.1, 0.3, 1.0 mg/kg; i.v.) efflux of extracellular NAS DA levels. This effect was abolished when rats were pretreated with atosiban (2 mg/kg; i.p.), suggesting that OT receptors mediate this OT action. Overall, our results suggest that OT receptors mediated OT potentiation of MP-induced stimulation of extracellular NAS DA levels, likely driven by modulation of DA receptor signaling pathways, without affecting MP blockade of DAT.

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Section: Discussionmentioning

confidence: 99%

Oxytocin receptors mediate oxytocin potentiation of methylphenidate‐induced stimulation of accumbens dopamine in rats

Hersey

Bacon

Bailey

et al. 2022

Journal of Neurochemistry

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“…Oxytocin (OT) 0.0116 mg/kg and antagonist atosiban (OTA) 1 mg/kg was prepared separately in 0.89% normal saline as we described previously [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus

Thakur

Shrivastava

2021

Metabolism Open

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“…Additionally, around birth, oxytocin release triggers a switch of the chloride equilibrium potential, turning GABA into an inhibitory neurotransmitter (while it is excitatory in the embryo), a process that is important to decrease the hypoxia associated with the transition of the oxygenation mode [96][97][98]. Furthermore, oxytocin action on GABA can increase (hypothalamus, cerebellum) or decrease GABA release (striatum, hippocampus, cortex, medulla oblongata) depending on brain region [99]. Notably though, most previous studies showing an association between the oxytocin and GABAergic systems were performed using male experimental subjects, without investigating any sex differences.…”

Section: Sex-specific Experience-dependent Neuromodulatory Mechanism ...mentioning

confidence: 99%

Sex-specific and social experience-dependent oxytocin–endocannabinoid interactions in the nucleus accumbens: implications for social behaviour

Borie

Young

Liu

2022

Phil. Trans. R. Soc. B

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Oxytocin modulates social behaviour across diverse vertebrate taxa, but the precise nature of its effects varies across species, individuals and lifetimes. Contributing to this variation is the fact that oxytocin's physiological effects are mediated through interaction with diverse neuromodulatory systems and can depend on the specifics of the local circuits it acts on. Furthermore, those effects can be influenced by both genetics and experience. Here we discuss this complexity through the lens of a specific neuromodulatory system, endocannabinoids, interacting with oxytocin in the nucleus accumbens to modulate prosocial behaviours in prairie voles. We provide a survey of current knowledge of oxytocin–endocannabinoid interactions in relation to social behaviour. We review in detail recent research in monogamous female prairie voles demonstrating that social experience, such as mating and pair bonding, can change how oxytocin modulates nucleus accumbens glutamatergic signalling through the recruitment of endocannabinoids to modulate prosocial behaviour toward the partner. We then discuss potential sex differences in experience-dependent modulation of the nucleus accumbens by oxytocin in voles based on new data in males. Finally, we propose that future oxytocin-based precision medicine therapies should consider how prior social experience interacts with sex and genetics to influence oxytocin actions. This article is part of the theme issue ‘Interplays between oxytocin and other neuromodulators in shaping complex social behaviours’.

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Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain

Cited by 7 publications

References 56 publications

Oxytocin receptors mediate oxytocin potentiation of methylphenidate‐induced stimulation of accumbens dopamine in rats

Oxytocin receptors mediate oxytocin potentiation of methylphenidate‐induced stimulation of accumbens dopamine in rats

Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus

Sex-specific and social experience-dependent oxytocin–endocannabinoid interactions in the nucleus accumbens: implications for social behaviour

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