Effects of Experimentally Induced Colibacillosis on the Pharmacokinetics of Ofloxacin in Chickens

Abstract

Colibacillosis was produced experimentally in 14 white Leghorn broiler chickens by intratracheal inoculation of 0.3 ml broth of E. coli O78:K80 containing approximately 10 6 colony forming unit. Another 7 clinically normal chickens were used in this study. Ofloxacin was administered to chickens intravenously and orally (5 mg/kg b.wt.) to determine the effect of colibacillosis on its kinetic behavior.