Effects of exposure to a time-varying 1.5 T magnetic field on the neurotransmitter-activated increase in intracellular Ca2+ in relation to actin fiber and mitochondrial functions in bovine adrenal chromaffin cells

Ikehara, Toshitaka; Nishisako, Hirotaka; Minami, Yoichi; Ichinose, Hiromi; Shiraishi, Tairo; Kitamura, Mitsuo; Shono, Masayuki; Kawazoe, Kazuyoshi; Minakuchi, Kazuo; Yoshizaki, Kazuo; Kinouchi, Yohsuke; Miyamoto, Hiroshi

doi:10.1016/j.bbagen.2010.09.001

Cited by 10 publications

(5 citation statements)

References 48 publications

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“…In fact, it has been suggested that the alteration of the blood level of this hormone consequent to ELF-MF exposure could result in a decreased protection against tumor growth [ 10 , 11 ]. On the other hand, studies on the central nervous system (CNS) showed a depressed activity of different types of neurotransmitter system and protein content in the brain of animals exposed to ELF-MF [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Extremely Low Frequency Magnetic Field Modulates the Level of Neurotransmitters

Chung

Lee

et al. 2015

Korean J Physiol Pharmacol

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This study was aimed to observe that extremely low frequency magnetic field (ELF-MF) may be relevant to changes of major neurotransmitters in rat brain. After the exposure to ELF-MF (60 Hz, 2.0 mT) for 2 or 5 days, we measured the levels of biogenic amines and their metabolites, amino acid neurotransmitters and nitric oxide (NO) in the cortex, striatum, thalamus, cerebellum and hippocampus. The exposure of ELF-MF for 2 or 5 days produced significant differences in norepinephrine and vanillyl mandelic acid in the striatum, thalamus, cerebellum and hippocampus. Significant increases in the levels of serotonin and 5-hydroxyindoleacetic acid were also observed in the striatum, thalamus or hippocampus. ELF-MF significantly increased the concentration of dopamine in the thalamus. ELF-MF tended to increase the levels of amino acid neurotransmitters such as glutamine, glycine and γ -aminobutyric acid in the striatum and thalamus, whereas it decreased the levels in the cortex, cerebellum and hippocampus. ELF-MF significantly increased NO concentration in the striatum, thalamus and hippocampus. The present study has demonstrated that exposure to ELF-MFs may evoke the changes in the levels of biogenic amines, amino acid and NO in the brain although the extent and property vary with the brain areas. However, the mechanisms remain further to be characterized.

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Section: Introductionmentioning

confidence: 99%

Extremely Low Frequency Magnetic Field Modulates the Level of Neurotransmitters

Chung

Lee

et al. 2015

Korean J Physiol Pharmacol

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“…EMF impinge on mitochondrial metabolism and physiology with the observed loss of cristae (48)(49) or cristae degeneration (50), mitochondrial generation of ROS (51), oxidation of mitochondrial DNA and reduced mitochondrial DNA copy number (52), lowered mitochondrial respiration (35,53), increased ADP/ATP ratio (54), and decreased mitochondrial membrane potential (53)(54)(55). In the present work, we show an increased quantity of the mitochondrial MTCO1/COX1 subunit 1 of cytochrome c oxidase, which points to a kind of a compensation mechanism.…”

Section: Discussionmentioning

confidence: 99%

Electromagnetic fields at a mobile phone frequency (900 MHz) trigger the onset of general stress response along with DNA modifications in Eisenia fetida earthworms

Bourdineaud

Šrut

Štambuk

et al. 2017

Archives of Industrial Hygiene and Toxicology

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Eisenia fetida earthworms were exposed to electromagnetic field (EMF) at a mobile phone frequency (900 MHz) and at field levels ranging from 10 to 120 V m-1 for a period of two hours (corresponding to specific absorption rates ranging from 0.13 to 9.33 mW kg-1). Potential effects of longer exposure (four hours), field modulation, and a recovery period of 24 h after two hours of exposure were addressed at the field level of 23 V m-1. All exposure treatments induced significant DNA modifications as assessed by a quantitative random amplified polymorphic DNA-PCR. Even after 24 h of recovery following a two hour-exposure, the number of probe hybridisation sites displayed a significant two-fold decrease as compared to untreated control earthworms, implying a loss of hybridisation sites and a persistent genotoxic effect of EMF. Expression of genes involved in the response to general stress (HSP70 encoding the 70 kDa heat shock protein, and MEKK1 involved in signal transduction), oxidative stress (CAT, encoding catalase), and chemical and immune defence (LYS, encoding lysenin, and MYD, encoding a myeloid differentiation factor) were up-regulated after exposure to 10 and modulated 23 V m-1 field levels. Western blots showing an increased quantity of HSP70 and MTCO1 proteins confirmed this stress response. HSP70 and LYS genes were up-regulated after 24 h of recovery following a two hour-exposure, meaning that the effect of EMF exposure lasted for hours.

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“…A possible explanation for the “exposure time window effect” could be an ELF‐MF exposure time‐dependent effect on calcium channels involved with the regulation of vasculogenesis and angiogenesis [Grassi et al, 2004; Morabito et al, 2010]. Another possibility is an ELF‐MF exposure time‐dependent effect over the calcium released from the endoplasmic reticulum [Ikehara et al, 2010]. It is known that the regulation of proliferation and motility of endothelial cells are crucial steps in angiogenesis and are dependent on the cytosolic calcium level.…”

Section: Discussionmentioning

confidence: 99%

Fractal analysis of extra‐embryonic vascularization in Japanese quail embryos exposed to extremely low frequency magnetic fields

Costa

Jimenez

Barbosa

et al. 2012

Bioelectromagnetics

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Magnetic fields (MF) can alter the dynamic behavior of vascular tissue and may have a stimulatory or inhibitory effect on blood vessel growth. Fractal geometry has been used in several studies as a tool to describe the development of blood vascular networks. Due to its self-similarity, irregularity, fractional dimension, and dependence on the scale of vessel dimensions, vascular networks can be taken as fractal objects. In this work, we calculated the fractal dimension by the methods of box counting (D(bc)) and information dimension (D(inf)) to evaluate the development of blood vessels of the yolk sac membrane (YSM) from quail embryos exposed to MF with a magnetic flux density of 1 mT and a frequency of 60 Hz. The obtained results showed that when the MF was applied to embryos aged between 48 and 72 h, in sessions of 2 h (6 h/day) and 3 h (9 h/day) with exposure intervals between 6 and 5 h, respectively, blood vascular formation was inhibited. Exposure sessions shorter than 2 h or longer than 3 h had no observable change on the vascular process. In contrast, the magnetic field had no observable change on the YSM vascular network for embryos aged between 72 and 96 h, irrespective of the exposure time. In conclusion, these results show a "window effect" regarding exposure time.

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Effects of exposure to a time-varying 1.5 T magnetic field on the neurotransmitter-activated increase in intracellular Ca2+ in relation to actin fiber and mitochondrial functions in bovine adrenal chromaffin cells

Cited by 10 publications

References 48 publications

Extremely Low Frequency Magnetic Field Modulates the Level of Neurotransmitters

Extremely Low Frequency Magnetic Field Modulates the Level of Neurotransmitters

Electromagnetic fields at a mobile phone frequency (900 MHz) trigger the onset of general stress response along with DNA modifications in Eisenia fetida earthworms

Fractal analysis of extra‐embryonic vascularization in Japanese quail embryos exposed to extremely low frequency magnetic fields

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