Effects of exposure to extremely low-frequency electromagnetic fields on the differentiation of Th17 T cells and regulatory T cells

Lee, Yun‐Jung; Hyung, Kyeong Eun; Yoo, J.E.; Jang, Ye Won; Kim, Soo Jeong; Lee, Do Ik; Lee, Sang Joon; Park, Soyoung; Jeong, Ji Hoon; Hwang, Kwang Woo

doi:10.4149/gpb_2016011

Cited by 14 publications

(9 citation statements)

References 28 publications

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“…4B). The differentiation of Th17 and Treg cells is mediated by downstream regulator STAT3 and STAT5 respectively (23). As expected, the expression of STAT3 was substantially increased and STAT5 was obviously decreased in splenic lymphocytes of TAC mice.…”

Section: The Effect Of Egcg On the Expressions Of Regulators Forsupporting

confidence: 64%

“…EGCG, Epigallocatechin gallate; TAC, transverse aortic constriction; Val, valsartan.naive Th cells, and exert opposite functions. The differentiation of Th17 depends on the activation of STAT3, while the development of Treg is mediated by the activation of STAT5(23). The imbalance of Th17/Treg is an important feature of inflammation and autoimmune diseases(33).…”

mentioning

confidence: 99%

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Epigallocatechin gallate attenuates overload-induced cardiac ECM remodeling via restoring T cell homeostasis

Han¹,

Wang²,

Fan³

et al. 2017

Molecular Medicine Reports

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It has previously been demonstrated that Epigallocatechin gallate (EGCG) has regulatory effects on cellular immunity. The present study explored whether EGCG inhibits the overload‑induced cardiac extracellular matrix (ECM) remodeling through targeting the balance of T cell subpopulations. Sprague‑Dawley rats were subjected to either transverse aortic constriction (TAC) or sham operation. TAC rats were treated with EGCG or valsartan (Val) for 6 weeks. The administration of EGCG or Val ameliorated the overproduction of cardiac collagen, inhibited matrix metalloproteinase (MMP) activity, decreased the expression of tissue inhibitor of MMP‑2, atrial natriuretic peptide and brain natriuretic peptide. EGCG regulated the population of effector T cells and naïve T cells, restored the balance of T helper (Th) cell 17/regulatory T cells, via modulating the downstream regulator signal transducer and activator of transcription (STAT3) and STAT5. Furthermore, the ratio of interferon‑γ/interleukin (IL)‑10 which indicates the balance of Th1/Th2, was restored by the treatments at varying degrees. EGCG and Val administration rescued IL‑7 production, and decreased the level of IL‑15 in TAC rats. EGCG has positive therapeutic potential in inhibiting cardiac ECM remodeling. Regulation of the balance of T lymphocyte subsets may be one of the underlying mechanisms responsible for this effect.

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Section: The Effect Of Egcg On the Expressions Of Regulators Forsupporting

confidence: 64%

mentioning

confidence: 99%

Epigallocatechin gallate attenuates overload-induced cardiac ECM remodeling via restoring T cell homeostasis

Han¹,

Wang²,

Fan³

et al. 2017

Molecular Medicine Reports

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“…Developmental pathways of Th17 and Treg cells are closely related. TGF-β alone induces expression of FoxP3 (30,31) and RORγT (31) in TCR-stimulated naive CD4 + T cells. Thus TGF-β is a critical factor for Th17 and Treg cells and is essential for inducing both RORγT and Foxp3.…”

Section: Cellular and Molecular Mechanisms Of Mdscmediated Immune Supmentioning

confidence: 99%

The paradoxical role of tumor-infiltrating immune cells in lung cancer

Zheng

Yao

2017

IRDR

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“…It was also found that ELF‐EMFs affected the expression of CD4, CD14, and CD16 [Conti et al, ]. Another study confirmed that ELF‐EMFs had effects on Th17 and Treg cells [Lee et al, ]. However, the Th9 subset is a recently‐discovered T helper cell subset and has not yet been studied extensively.…”

Section: Discussionmentioning

confidence: 99%

“…Each coil was made of 200 turns of 1‐mm diameter insulated soft copper wire and was connected in series to a 220‐V alternating current power supply via a transformer. Details of the methods were described in our previous study [Lee et al, ; Kim et al, ].…”

Section: Methodsmentioning

confidence: 99%

T‐Cell Differentiation to T Helper 9 Phenotype is Elevated by Extremely Low‐Frequency Electromagnetic Fields Via Induction of IL‐2 Signaling

Jang

Gil

Lee

et al. 2019

Bioelectromagnetics

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Owing to the development of information technology and the electronics industry, and the increase in the use of electronic products, an increasing number of people are exposed to electromagnetic fields (EMFs) in daily life. There has been concern about the effects of EMFs on the human body. Th9 cells, which are characterized by the generation of interleukin-(IL-9), are a recently defined subset of T helper (Th) cells. In this study, we investigated the effect of extremely low-frequency (60 Hz) EMFs, such as those generated by household power sources, at 0.8 mT intensity on CD4 + T cells. The exposure of CD4 + T cells to such EMFs under Th9-polarizing conditions increased IL-9 secretion and gene expression of transcription factors that are important for Th9 development. The expression of GATA3 increased in the early stage, and the phosphorylation of STAT5 and STAT6, which regulate the expression of GATA3, increased. In addition, EMFs increased the expression of IL-2 by the T cells. In conclusion, the differentiation of CD4 + T cells to the Th9 phenotype was increased by exposure to extremely low-frequency EMFs, and this appeared to be dependent on the IL-2 signaling pathway. Furthermore, co-cultures of EMF-exposed Th9 cells and mast cells showed an increased expression of mast cell proteases, FcεR1α, and mast cell-derived inflammatory cytokines compared with co-cultures of non-EMF-exposed Th9 cells and mast cells. Our results suggest that EMFs enhance the differentiation of CD4 + T cells to the Th9 phenotype, resulting in mast cell activation and inflammation. Bioelectromagnetics. 2019;40:588-601.

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Effects of exposure to extremely low-frequency electromagnetic fields on the differentiation of Th17 T cells and regulatory T cells

Cited by 14 publications

References 28 publications

Epigallocatechin gallate attenuates overload-induced cardiac ECM remodeling via restoring T cell homeostasis

Epigallocatechin gallate attenuates overload-induced cardiac ECM remodeling via restoring T cell homeostasis

The paradoxical role of tumor-infiltrating immune cells in lung cancer

T‐Cell Differentiation to T Helper 9 Phenotype is Elevated by Extremely Low‐Frequency Electromagnetic Fields Via Induction of IL‐2 Signaling

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