Effects of exposure to night shift work on cancer risk in workers

Ritonja, Jennifer; Papantoniou, Kyriaki; Ebenberger, Agnes; Wagner, Gernot; Gartlehner, Gerald; Klerings, Irma; Herkner, Harald; Aronson, Kristan J.; Schernhammer, Eva

doi:10.1002/14651858.cd013466

Cited by 3 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Examples of night-shift work-related risks included increases in breast cancer among women [39] and prostate cancer among men [40]. The disproportionate increase in cancer among night-shift workers is potentially related to a disruption of melatonin activities [41].…”

Section: Management Of Sleep Disturbances As An Adjunctive Cancer The...mentioning

confidence: 99%

See 1 more Smart Citation

Review of Under-Recognized Adjunctive Therapies for Cancer

Money

Matthews

Tan-Shalaby

2022

Cancers

View full text Add to dashboard Cite

Patients and providers may not be aware that several adjunctive measures can significantly improve the quality of life, response to treatment, and possibly outcomes for cancer patients. This manuscript presents a review of practical under-recognized adjunctive therapies that are effective including exercise; stress-reduction techniques such as mindfulness, massage, yoga, Tai Chi, breathing exercises; importance of sleep quality; diet modifications such as calorie restriction at the time of chemotherapy and avoidance of high carbohydrate foods; supplements such as aspirin, green tea, turmeric, and melatonin; and repurposed prescription medications such as metformin and statins. Each recommendation should be tailored to the individual patient to assure no contraindications.

show abstract

Section: Management Of Sleep Disturbances As An Adjunctive Cancer The...mentioning

confidence: 99%

“…In addition, melatonin is an anti-inflammatory agent, has anti-angiogenetic effects, and potentiates cancer cell apoptosis [51]. It has also been shown to potentiate the actions of other antioxidants and chemotherapy agents [41,52].…”

Section: Melatonin a Potential Chemotherapy Agentmentioning

confidence: 99%

Review of Under-Recognized Adjunctive Therapies for Cancer

Money

Matthews

Tan-Shalaby

2022

Cancers

View full text Add to dashboard Cite

show abstract

“…Because of the tight regulation of circadian oscillations in many crucial proteins, chronic disruption of an individual’s internal clock leads to serious health issues, including cancer. The International Agency for Research on Cancer and the National Toxicology Program (United States) have officially classified night shift work as a likely carcinogen [ 23 ]. Breast and prostate cancer are among the most likely outcomes of proto-oncogenic circadian disruption due to the estrogen and aromatase-suppressing properties of melatonin [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…The International Agency for Research on Cancer and the National Toxicology Program (United States) have officially classified night shift work as a likely carcinogen [ 23 ]. Breast and prostate cancer are among the most likely outcomes of proto-oncogenic circadian disruption due to the estrogen and aromatase-suppressing properties of melatonin [ 23 , 24 ]. Indeed, circadian rhythm disruption is a risk factor for breast cancer development.…”

Section: Introductionmentioning

confidence: 99%

Chronotherapeutics for Solid Tumors

Kisamore,

Elliott,

DeVries

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Circadian rhythms are internal manifestations of the 24-h solar day that allow for synchronization of biological and behavioral processes to the external solar day. This precise regulation of physiology and behavior improves adaptive function and survival. Chronotherapy takes advantage of circadian rhythms in physiological processes to optimize the timing of drug administration to achieve maximal therapeutic efficacy and minimize negative side effects. Chronotherapy for cancer treatment was first demonstrated to be beneficial more than five decades ago and has favorable effects across diverse cancer types. However, implementation of chronotherapy in clinic remains limited. The present review examines the evidence for chronotherapeutic treatment for solid tumors. Specifically, studies examining chrono-chemotherapy, chrono-radiotherapy, and alternative chronotherapeutics (e.g., hormone therapy, TKIs, antiangiogenic therapy, immunotherapy) are discussed. In addition, we propose areas of needed research and identify challenges in the field that remain to be addressed.

show abstract

Circadian Rhythm Disruption in Cancer Survivors: From Oncogenesis to Quality of Life

Kisamore,

Walker

2024

Cancer Medicine

View full text Add to dashboard Cite

BackgroundCircadian rhythms are approximately 24‐hour cycles in physiological and behavioral processes. They are entrained to the external solar day via blue wavelength light. Disruptions in these intrinsic rhythms can lead to circadian dysfunction, which has several negative implications on human health, including cancer development and progression.AimsHere we review the molecular mechanisms of circadian disruption and their impact on tumor development and progression, discuss the interplay between circadian dysfunction and cancer in basic scientific studies and clinical data, and propose the potential clinical implications of these data that may be used to improve patient outcomes and reduce cost of treatment.Materials & MethodsUsing scientific literature databases, relevant studies were analyzed to draw overarching conclusions of the relationship between circadian rhythm dysruption and cancer.ConclusionsCircadian disruption can be mediated by a number of environmental factors such as exposure to light at night, shift work, jetlag, and social jetlag which drive oncogenesis. Tumor growth and progression, as well as treatment, can lead to long‐term alterations in circadian rhythms that negatively affect quality of life in cancer survivors.

show abstract

Effects of exposure to night shift work on cancer risk in workers

Cited by 3 publications

References 48 publications

Review of Under-Recognized Adjunctive Therapies for Cancer

Review of Under-Recognized Adjunctive Therapies for Cancer

Chronotherapeutics for Solid Tumors

Circadian Rhythm Disruption in Cancer Survivors: From Oncogenesis to Quality of Life

Contact Info

Product

Resources

About