Effects of exposure to Prestige-like heavy fuel oil and to perfluorooctane sulfonate on conventional biomarkers and target gene transcription in the thicklip grey mullet Chelon labrosus

Bilbao, Eider; Raingeard, Damien; Cerio, Oihane Díaz de; Ortiz-Zarragoitia, Maren; Ruiz, Pamela; Izagirre, Urtzi; Orbea, Amaia; Marigómez, Ionan; Cajaraville, Miren P.; Cancio, Ibon

doi:10.1016/j.aquatox.2010.02.018

Cited by 77 publications

(35 citation statements)

References 79 publications

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“…As reported before (Beach et al 2006), PFOS can pose strong lethal effects, but the mechanism(s) behind is still unknown. Austin et al (2003) and Bilbao et al (2010) reported a lowered food intake and narcotic effects that concerted with a fitness reduction by PFOS, but none of these symptoms were seen in the treated bumblebee workers in this study. However, we could demonstrate that the mitochondrial ETS activity was lowered by 26% in the treated bumblebee workers.…”

Section: Discussioncontrasting

confidence: 69%

“…Next to metabolic costs, there was a clear antagonistic EcR activity in the presence of 20E by all PFOS concentrations tested and this without loss of viability of the reporter S2 cells, providing strong evidence of interference with the hormonal regulation of insect development and reproduction. In the past, multiple studies have reported endocrine disrupting properties for PFOS, and these authors specifically referred to alterations in hormone biosynthesis and hormone responsive genes (Biegel et al 1995;Austin et al 2003;Lau et al 2003;Ankley et al 2005;Hu et al 2005;Oakes et al 2005;Shi et al 2007;Hagenaars et al 2008;Jensen and Leffers 2008;Wei et al 2008;Bilbao et al 2010). Most notable, the current experiments with ecdysteroid-responsive S2 cells demonstrated for the first time that PFOS can mediate endocrine effects via interference with the function of the ecdysteroid hormone receptor EcR.…”

Section: Discussionmentioning

confidence: 75%

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Impact of a perfluorinated organic compound PFOS on the terrestrial pollinator Bombus terrestris (Insecta, Hymenoptera)

et al. 2011

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Perfluorinated organic chemicals like perfluorooctane sulfonic acid (PFOS) are persistent environmental pollutants that have been measured in a great diversity of wildlife worldwide, especially in the aquatic compartment. However, little information is available on the presence and effects of PFOS in the terrestrial compartment. Therefore, we investigated in this project the risks for effects, bioaccumulation and potential mechanisms of activity of PFOS in the bumblebee Bombus terrestris L. (Hymenoptera: Apidae) that is an important worldwide pollinator in the terrestrial compartment of wildflowers and cultivated crops. The exposure to PFOS occurred orally via the drinking of treated sugar water in a wide range from 1 μg/l up to 10 mg/l, containing environmentally relevant as well as high concentrations, and this was done with use of microcolonies of B. terrestris in the laboratory. A chronic toxicity assay demonstrated high bumblebee worker mortality (up to 100%) with an LC(50) of 1.01 mg/l (R(2) = 0.98). In addition, PFOS posed strong detrimental reproductive effects, and these concerted with a dramatic reduction in ovarian size. HPLC-MS demonstrated a bioaccumulation factor of 27.9 for PFOS in bumblebee workers fed with sugar water containing 100 μg/l PFOS during 5 weeks (2184 ± 365 ng/g BW). Finally, potential mechanisms of activity were investigated to explain the significant impact of PFOS on survival and reproduction capacity of B. terrestris. Exposure of bumblebee workers to PFOS resulted in a significant decrease in mitochondrial electron transport activity (p = 0.035) and lipid amounts (p = 0.019), while the respective p-values were 0.58 and 0.12 for protein and glucose amounts. Hence, addition of PFOS to ecdysteroid responsive Drosophila melanogaster S2 cells resulted in a strong antagonistic action on the EcR-b.act.luc reporter construct, demonstrating that PFOS may exert its effects partially through an endocrine disrupting action via the insect molting hormone or ecdysteroid receptor.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 75%

Impact of a perfluorinated organic compound PFOS on the terrestrial pollinator Bombus terrestris (Insecta, Hymenoptera)

et al. 2011

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“…In the water flea Daphnia magna, BDE similarly controlled ecdysteroid hormone, leading to disruption of the developmental molting process (Davies and Zou, 2012). Moreover, PFOS was shown to induce alterations in hormone biosynthesis and impaired development and metamorphosis in the rat (Austin et al, 2003), fathead minnow (Ankley et al, 2005), and thicklip gray mullet (Bilbao et al, 2010). These results indicated that the internal secretion of ecdysteroid hormone was disturbed by BDE-47 and PFOS in T. japonicus, leading to alterations of the endocrine secreting system that regulates the normal molting process.…”

Section: Discussionmentioning

confidence: 97%

Developmental retardation, reduced fecundity, and modulated expression of the defensome in the intertidal copepod Tigriopus japonicus exposed to BDE-47 and PFOS

et al. 2015

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“…In seabird colonies, successful annual reproduction was still 70% lower than historical rates, 5 yr after the Prestige oil spill (Barros et al 2014). Reproductive and early developmental effects have also been documented in fish species exposed to oil from the Exxon Valdez, Prestige, and Deep water Horizon spills (Hawkes & Stehr 1982, Kocan et al 1996, Bilbao et al 2010, de Soysa et al 2012, Kawa guchi et al 2012, Whitehead et al 2012, Turner et al 2014.…”

Section: Introductionmentioning

confidence: 99%

Low reproductive success rates of common bottlenose dolphins Tursiops truncatus in the northern Gulf of Mexico following the Deepwater Horizon disaster (2010-2015)

Kellar¹,

Speakman²,

Smith³

et al. 2017

Endang. Species. Res.

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Following the Deepwater Horizon (DWH) oil spill, reproductive success rates in 2 northern Gulf of Mexico (GoM) bottlenose dolphin stocks exposed to oil were evaluated for 4 yr during and after the spill (2010 to 2015) in efforts to assess population-level reproductive health. Pregnancy was determined from either (1) ultrasound examinations of the reproductive tract during capture-release health assessments, or (2) endocrine evaluations of blubber tissue collected from dart biopsies of free-ranging dolphins. Follow-up photo-identification was then used to track the status of pregnant females and any associated neonatal calves for a minimum of 1 yr after the initial pregnancy detection (IPD). For all pregnant females observed following IPD, individuals seen with a calf (reproductive success) and without one (reproductive failure) were recorded. The resulting estimated reproductive success rates for both GoM stocks (19.4%; 7/36) were less than a third of those previously reported in other areas not impacted by the spill (i.e. Sarasota Bay, FL; Indian River Lagoon, FL; and Charleston Harbor, SC) using similar techniques (64.7%; 22/34). We also evaluated the relationships between reproductive success and 13 potential covariates, including stock, ordinal date, progesterone, cortisol, thyroid hormone concentrations, leukocyte count, lung health score, and total body length. Among these, the results only provide strong evidence (Bayes factor > 20) of a relationship between reproductive failure and the total leukocyte count covariate. The high reproductive failure rates measured in both GoM stocks following the DWH oil spill are consistent with mammalian literature that shows a link between petroleum exposure and reproductive abnormalities and failures.

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Effects of exposure to Prestige-like heavy fuel oil and to perfluorooctane sulfonate on conventional biomarkers and target gene transcription in the thicklip grey mullet Chelon labrosus

Cited by 77 publications

References 79 publications

Impact of a perfluorinated organic compound PFOS on the terrestrial pollinator Bombus terrestris (Insecta, Hymenoptera)

Impact of a perfluorinated organic compound PFOS on the terrestrial pollinator Bombus terrestris (Insecta, Hymenoptera)

Developmental retardation, reduced fecundity, and modulated expression of the defensome in the intertidal copepod Tigriopus japonicus exposed to BDE-47 and PFOS

Low reproductive success rates of common bottlenose dolphins Tursiops truncatus in the northern Gulf of Mexico following the Deepwater Horizon disaster (2010-2015)

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