Effects of Extracorporeal Shock Wave Therapy on Distraction Osteogenesis in Rat Mandible

Abstract

Extracorporeal shock wave therapy application at the consolidation period during distraction osteogenesis in the rat mandible enhances bone formation and osteogenic and angiogenic growth factors, improves bone mechanical properties, and accelerates bone mineralization.

In Vivo Modulation of Angiogenesis and Immune Response on a Collagen Matrix via Extracorporeal Shockwaves

“…Strengthening of the individual ability to integrate the implanted foreign material may serve as a new approach to guide the body’s endogenous regenerative capacity to achieve a favorable tissue repair. ESWT is an FDA-approved therapy for musculoskeletal disorders and more and more it is also suggested for several other areas of application [ 15 ]. ESWT is said to improve the tissue vascularization and to help to modulate the immunological response to foreign materials [ 21 , 23 , 26 , 34 ].…”

“…Extracorporeal shockwave therapy (ESWT) is defined as a biphasic change of pressure during a short period of time with a positive wave of high intensity (40 MPa, ~1 μs duration) and a negative wave of low intensity (10 MPa, ~3 μs duration) [ 13 ]. It was first used to treat kidney stones [ 14 ]; today, radial and focused ESWT are FDA-approved therapies for the treatment of musculoskeletal disorders and a variety of off-label applications [ 15 ]. Radial shockwaves are generated by firing a projectile within a guiding tube that strikes a metal applicator placed on the patients’ skin.…”

“…It is thought to induce an asymmetrical fluid stream within the tissue [ 13 ]. Furthermore, it was suggested that membrane hyperpolarization and the formation of free radicals may be sources of the biological effects [ 15 ]. Several studies could show a positive effect of ESWT on tissue regeneration and cellular proliferation [ 14 , 17 , 18 , 19 , 20 ].…”

“…Several studies could show a positive effect of ESWT on tissue regeneration and cellular proliferation [ 14 , 17 , 18 , 19 , 20 ]. In a rat model, VEGF was significantly increased in hard and soft tissue samples after ESWT [ 15 , 21 ]. HIF-1α levels were significantly elevated in osteoblasts after in vitro stimulation [ 22 ] and ESWT-stimulated tissues showed higher vascularization both in animal and human trials [ 22 , 23 , 24 , 25 ].…”

Assessment of Quality in Osteoporotic Human Trabecular Bone and Its Relationship to Mechanical Properties

“…For example, in [19], significant variations in structural composition of trabeculae were found among patients with adolescent idiopathic scoliosis (AIS) and agematched congenital scoliosis (CS). Other studies interested in trabecular conformation are related to the treatment of congenital and acquired craniofacial deformities [20], congenital hypogonadotropic hypogonadism (CHH), Kallmann syndrome (KS) [21], and telomere dysfunction [22].…”