Effects of Extract from Solid-State FermentedCordyceps sinensison Type 2 Diabetes Mellitus

Abstract

Diabetes mellitus is the most common chronic disease in the world, and a wide range of drugs, including Chinese herbs, have been evaluated for the treatment of associated metabolic disorders. This study investigated the potential hypoglycemic and renoprotective effects of an extract from the solid-state fermented mycelium of Cordyceps sinensis (CS). We employed the KK/HIJ diabetic mouse model, in which the mice were provided with a high-fat diet for 8 weeks to induce hyperglycemia, followed by the administration of CS or rosiglitazone for 4 consecutive weeks. Several parameters were evaluated, including changes in body weight, plasma lipid profiles, oral glucose tolerance tests, insulin tolerance tests, and plasma insulin concentrations. Our results show that the CS extract significantly elevated HDL/LDL ratios at 4 weeks and decreased body weight gain at 8 weeks. Interestingly, CS treatment did not lead to obvious improvements in hyperglycemia or resistance to insulin, while in vitro MTT assays indicated that CS protects pancreatic beta cells against the toxic effects of STZ. CS also enhanced renal NKA activity and reduced the accumulation of mesangial matrix and collagen deposition. In conclusion, CS extract can potentially preserve β-cell function and offer renoprotection, which may afford a promising therapy for DM.

Studies on the Antidiabetic Activities ofCordyceps militarisExtract in Diet-Streptozotocin-Induced Diabetic Sprague-Dawley Rats

“…Being consistent with previous findings [48], AE shows poorer hypoglycemic activity compared with WE. It may be due to the better solubility and absorption of WE; however, more experiments need to be performed to investigate the difference between them.…”

Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats

“…C. sinensis has been proven to consist of active constituents, such as mannitol, nucleosides, ergosterol, aminophenol and trace elements . Increasing evidence has shown that C. sinensis has an effect on ischemia/reperfusion renal injury, diabetic nephropathy, spontaneous hypertensive and allograft rejection renal disease in animal experiments or human clinical treatments (Ding et al, 2009;Kan et al, 2012;Wang et al, 2012;Wu et al, 2010). However, the mechanism by which C. sinensis attenuates renal fibrosis is still largely unknown.…”

Xiaokening stimulates endothelial nitric oxide release in diabetic rats

“…Reduced NO release in diabetes mellitus damages the dilation function of arterioles. (24,25) Chinese medicines have been found to have the ability to prevent and treat diabetic nephropathy in the early stages; (26)(27)(28)(29) this may be due to the fact that they are often made of diverse effective components, which are able to act on different targets of diabetic nephropathy. The compound preparation Xiaokening is composed of extractions of rhubarb, radix aconiti lateralis preparata and crude radix astragali.…”