Effects of Extracts of Triplochiton Scleroxylon (K. Schum) on Plasma Glucose and Malondialdehyde Concentrations in Normal and Streptozotocin-Induced Diabetic Rats.

Onoagbe, I. O.

doi:10.5455/jppa.20121221031603

Cited by 11 publications

(9 citation statements)

References 15 publications

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“…Diosgenin, a steroid sapogenin extracted from yam, is used as precursor for the synthesis of hormones and corticosteroids which improve fertility in males (Djerassi1992). Saponins possesses both beneficial effects (cholesterollowering) and deleterious properties (cytotoxic permeabilization of the intestine) and also exhibit structure dependent biological activities (Prohp and Onoagbe, 2012). The biological functions of flavonoids apart from its antioxidant properties include; protection against allergies, inflammation, free radicals, platelet aggregation, microbes, ulcers, hepatoxins, viruses and tumors (Trease and Evans, 2002).…”

Section: Phytochemical Composition Of Aerial Yam (Dioscorea Bulbiferamentioning

confidence: 99%

Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour

et al. 2017

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Section: Phytochemical Composition Of Aerial Yam (Dioscorea Bulbiferamentioning

confidence: 99%

Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour

et al. 2017

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“…It is very necessary to determine LD 50 to prevent eventualities of drug or compounds overdose that may hinder the therapeutic value of the drug. 34 The study is also useful in understanding toxicity profiles of plant extracts. 35 The result of acute oral toxicity study in the rats recorded an LD 50 of less than5000 mg/kg ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Solvent Extracts of Tephrosia vogelii Leaves and Stem on Lipid Profile of Poloxamer 407-Induced Hyperlipidemic Rats

Bawa

Uti

Itodo

et al. 2022

Ibnosina Journal of Medicine and Biomedical Sciences

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Introduction There are claims by traditional medicine practitioners in Nigeria and valuable scientific reports that the leaves of Tephrosia vogelii (TV) hook are used for the treatment of various diseases; however, there is paucity of information on it used in the management of cardiovascular complications despite the rich presence of phytochemicals. This study aimed at investigating effects of solvents extracts of TV leaves and stem on lipid profile of poloxamer 407-induced hyperlipidemic rats. Materials and Methods Varying doses of the solvent extracts (water, ethanol, and acetic acid) of plant material were administered to experimental animals (Albino Wistar rats) induced with hyperlipidemia using poloxamer 407 (P-407). Results The results of the phytochemical screening of leaves and stem revealed the presence of alkaloids, saponins, phlobatannins, and flavonoids in powdered sample of leaves and stem of TV. Aqueous extract of the leaves had the highest yield (18.21 ± 1.12%), while acetic acid extract of stem had the lowest yield (7.21 ± 1.21%). The cholesterol and triacylglycerol level of rats induced with P-407 was significantly (p≤0.05) higher than normal rats. This study showed that aqueous extract at 50mg/kg body weight significantly (p≤0.05) lower cholesterol, low-density lipoprotein, very low-density lipoprotein, and triacylglycerol levels. Indices of cardiovascular function atherogenic coefficient, atherogenic index, coronary risk index, and cardioprotective index were positively modulated by the treatment. Conclusion The study indicated that the aqueous leaves extract of TV possesses antihyperlipidemic effects and may explains why it has been found to be useful in the management of cardiovascular diseases by traditional medicine practitioners.

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“…Degradation of polyunsaturated fatty acid peroxides yields MDA as one of the end products and the measurement of this compound has been used as an indicator of lipid peroxidation [46]. Group 5 produced the highest MDA concentration; followed by group 3 while group 4 produced the least MDA concentration on day 3 post treatment.…”

Section: Discussionmentioning

confidence: 99%

Free Radical Scavenging Property of <i>Picralima nitida</i> Seed Extract on Malaria-Induced Albino Mice

E.¹

2017

AJLS

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Antioxidants help to mop up free radicals that serious damage to the body system and hence are referred to as free radical scavengers. The main objective of this study was to assess the antioxidant property of ethanol seed extract of Picralima nitida in malaria-induce mice. The activities of the antioxidant enzymes myeloperoxidase (MPO), superoxide dismutase (SOD), thioredoxin reductase (TrxR) were assayed; malondialdehyde (MDA) and nitrite levels were determined. The levels of nitrite and MDA and the SOD activity of the drug-treated groups of mice were significantly (p < 0.05) lower on days 3 and 5 post treatment compared to the group induced with malaria but not treated (positive control). The MPO activity of the drugtreated groups of mice was significantly (p < 0.05) higher on day 3 post treatment while its activity in mice treated with 40 and 80 mg/kg b.w. of the extract were significantly (p < 0.05) lower on day 5 post treatment compared to the positive control. In the group treated with 80 mg/kg b.w. of the extract, the TrxR activity was significantly (p < 0.05) lower on days 3 and 5 post treatment compared to the positive control. Picralima nitida seed extract was found to possess good antioxidant properties.

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Effects of Extracts of Triplochiton Scleroxylon (K. Schum) on Plasma Glucose and Malondialdehyde Concentrations in Normal and Streptozotocin-Induced Diabetic Rats.

Cited by 11 publications

References 15 publications

Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour

Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour

Effect of Solvent Extracts of Tephrosia vogelii Leaves and Stem on Lipid Profile of Poloxamer 407-Induced Hyperlipidemic Rats

Free Radical Scavenging Property of <i>Picralima nitida</i> Seed Extract on Malaria-Induced Albino Mice

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Effects of Extracts of Triplochiton Scleroxylon (K. Schum) on Plasma Glucose and Malondialdehyde Concentrations in Normal and Streptozotocin-Induced Diabetic Rats.

Cited by 11 publications

References 15 publications

Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour

Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour

Effect of Solvent Extracts of Tephrosia vogelii Leaves and Stem on Lipid Profile of Poloxamer 407-Induced Hyperlipidemic Rats

Free Radical Scavenging Property of &lt;i&gt;Picralima nitida&lt;/i&gt; Seed Extract on Malaria-Induced Albino Mice

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Free Radical Scavenging Property of <i>Picralima nitida</i> Seed Extract on Malaria-Induced Albino Mice