Effects of extrinsic autonomic denervation and myenteric plexus transection on colonic motility in conscious dogs

Tanabe, Yoshitaka; Hotokezaka, Masayuki; Mibu, Ryuichi; Tanaka, Masao

doi:10.1067/msy.2002.126511

Cited by 12 publications

(5 citation statements)

References 34 publications

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“…of CNMC significantly decreased and %CMMC increased. Tanabe et al 29 showed that extrinsic autonomic denervation of the entire colon and ID at the proximal colon significantly increased %CMMC -in close agreement with our resultssuggesting that intrinsic myenteric plexus may inhibit propagation of CMMC. In addition, in the groups in which %CMMC increased, fecal moistness increased.…”

Section: Discussionsupporting

confidence: 92%

Effects of denervation at ileocecal junction and ileocecal resection in dogs

Morita

Mochiki

Ogawa

et al. 2011

Neurogastroenterology Motil

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Section: Discussionsupporting

confidence: 92%

Effects of denervation at ileocecal junction and ileocecal resection in dogs

Morita

Mochiki

Ogawa

et al. 2011

Neurogastroenterology Motil

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“…These contractions may clean the colon in preparation for the next influx of residue from the terminal ileum. To a certain extent, our findings were similar to those shown in previous reports, 1,7,16,20 however, in our study, the mean MI of C5 (located on the rectum) was the minimum, and the mean duration of C5 was not the longest, perhaps because of differences in the locations of the force transducers and technical procedures as well as a decrease in the number of cholinergic fibres in the aborad direction in the colon. The number of cholinergic fibres may be the lowest in the rectum, as a previous report revealed.…”

Section: Discussionsupporting

confidence: 92%

“…The ascending fibres from the pelvic plexus were, for the most part, preserved, and colonic continuity was reconstructed by end-to-end, layer-to-layer anastomosis. In the fourth group (dogs [16][17][18][19][20], the procedures used in the second and third groups were performed simultaneously. This model corresponds to AR in humans with injury to of the extrinsic and enteric nervous systems.…”

Section: Animal Preparationmentioning

confidence: 99%

“…[13][14][15] In practice, defecatory disorders are often observed even after the recovery of anorectal function; therefore, we assume that changes in colonic motility are among the most important features of defecatory disorders. Several reports have indicated that extrinsic innervation is not necessarily required for the appearance of colonic contractions, [16][17][18][19] and Tanabe et al 20 reported the effect of extrinsic autonomic denervation on colonic contractile activity. However, such a model cannot be observed in clinical surgery, and the precise role of the autonomic nerves in colonic motility as well as the correlation between colonic motility and defecatory disorders is not well understood.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between colonic motility and defecatory disorders after anterior resection of the rectum in canine models

Tabe

Mochiki

Ando

et al. 2008

Neurogastroenterology Motil

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The objective of this study was to describe the correlation between changes in colonic motility and defecatory disorders in four experimental canine models, with an emphasis on denervation. Therefore, we constructed a model by dividing 20 healthy mongrel dogs into four groups, i.e. control, denervation, transection and anterior resection of the rectum (AR) (denervation plus transection), and focused on the correlation between colonic motility and defecatory disorders by counting the colonic migrating motor complexes (CMMCs) and colonic non-migrating motor complexes (CNMCs). Gastrointestinal and colonic contractile activities were continuously recorded on a computer with strain gauge force transducers. The dogs' feces were checked daily, and their consistency was recorded as normal, semisolid, or watery. Compared with the control group, the transection group showed elongation of the propagation time (P < 0.05), and the mean motility index of colonic contractile activity at C4 and C5 in the denervation group was greater than that in the control group (P < 0.05). The AR group showed three features of colonic motility: (i) elongation of the mean CMMC cycle (P < 0.05); (ii) shortening of the propagation time (P < 0.05); and (iii) increment of the number of CNMCs. Concerning fecal consistency, the AR group only showed watery diarrhoea. In conclusion, we revealed the existence of a correlation between defecatory disorders and changes in colonic motility. Increased knowledge among colorectal surgeons of the changes in colonic motility that occur following colorectal surgery is very important and could lead to the curtailment of defecatory disorders among patients.

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“…Long denervation occurs when the IMA is transected at its origin (high ligation), and short denervation when the LCA is preserved (low ligation). Changes in colonic motility of the denervated neorectum have been assessed in various animal models. There is a possibility that high ligation of the IMA is associated with poor postoperative bowel function compared with that following low ligation.…”

Section: Discussionmentioning

confidence: 99%